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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 3
1981 2
1982 5
1983 3
1985 21
1986 6
1987 25
1988 31
1989 34
1990 76
1991 79
1992 92
1993 129
1994 138
1995 177
1996 181
1997 187
1998 223
1999 243
2000 226
2001 246
2002 248
2003 253
2004 279
2005 260
2006 242
2007 288
2008 244
2009 268
2010 277
2011 247
2012 248
2013 283
2014 302
2015 268
2016 237
2017 237
2018 194
2019 153
2020 194
2021 176
2022 210
2023 212
2024 76

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7,009 results

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Page 1
Safety and efficacy of ciprofol vs. propofol for sedation in intensive care unit patients with mechanical ventilation: a multi-center, open label, randomized, phase 2 trial.
Liu Y, Yu X, Zhu D, Zeng J, Lin Q, Zang B, Chen C, Liu N, Liu X, Gao W, Guan X. Liu Y, et al. Chin Med J (Engl). 2022 May 5;135(9):1043-1051. doi: 10.1097/CM9.0000000000001912. Chin Med J (Engl). 2022. PMID: 34924506 Free PMC article. Clinical Trial.
The phase 2 trial was designed to investigate the safety, efficacy, and pharmacokinetic characteristics of ciprofol for sedation of patients undergoing mechanical ventilation. METHODS: In this multicenter, open label, randomized, propofol positive-controlled, phase 2 trial …
The phase 2 trial was designed to investigate the safety, efficacy, and pharmacokinetic characteristics of ciprofol for sedation of patients …
Effects of ciprofol for the induction of general anesthesia in patients scheduled for elective surgery compared to propofol: a phase 3, multicenter, randomized, double-blind, comparative study.
Wang X, Wang X, Liu J, Zuo YX, Zhu QM, Wei XC, Zou XH, Luo AL, Zhang FX, Li YL, Zheng H, Li H, Wang S, Wang DX, Guo QL, Liu CM, Wang YT, Zhu ZQ, Wang GY, Ai YQ, Xu MJ. Wang X, et al. Eur Rev Med Pharmacol Sci. 2022 Mar;26(5):1607-1617. doi: 10.26355/eurrev_202203_28228. Eur Rev Med Pharmacol Sci. 2022. PMID: 35302207 Free article. Clinical Trial.
RESULTS: The anesthesia induction success rates for both ciprofol 0.4 mg/kg and propofol 2 mg/kg groups were 100.0%, with a 95% CI lower success limit of -4.18% difference between the two groups, indicating that ciprofol was non-inferior to propofol. ...Safety was c …
RESULTS: The anesthesia induction success rates for both ciprofol 0.4 mg/kg and propofol 2 mg/kg groups were 100.0%, with a 95% CI lo …
Efficacy and safety of ciprofol versus propofol for the induction of anesthesia in adult patients: a multicenter phase 2a clinical trial.
Zhu Q, Luo Z, Wang X, Wang D, Li J, Wei X, Tang J, Yao S, Ouyang W, Zhang W, Zuo Y, Wang X, Liu J. Zhu Q, et al. Int J Clin Pharm. 2023 Apr;45(2):473-482. doi: 10.1007/s11096-022-01529-x. Epub 2023 Jan 21. Int J Clin Pharm. 2023. PMID: 36680620 Free PMC article. Clinical Trial.
Ten patients per group were assigned to ciprofol-0.3, 0.4 and 0.5 mg/kg, and propofol-2.0 or 2.5 mg/kg groups, respectively to receive an intravenous bolus dose. ...There were no significant differences in the incidences and severity of AEs in the dose ranges investigated …
Ten patients per group were assigned to ciprofol-0.3, 0.4 and 0.5 mg/kg, and propofol-2.0 or 2.5 mg/kg groups, respectively to receiv …
Effects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled Study.
Duan J, Ju X, Wang X, Liu N, Xu S, Wang S. Duan J, et al. Drug Des Devel Ther. 2023 Sep 1;17:2669-2678. doi: 10.2147/DDDT.S419146. eCollection 2023. Drug Des Devel Ther. 2023. PMID: 37680862 Free PMC article. Clinical Trial.
PURPOSE: The aim of this study was to compare the effects of remimazolam and propofol on emergence agitation (EA) in elderly patients undergoing hip replacement. ...They were randomly assigned to two groups: the remimazolam group (group R) and the propofol group (gr …
PURPOSE: The aim of this study was to compare the effects of remimazolam and propofol on emergence agitation (EA) in elderly patients …
Supraglottic jet oxygenation and ventilation reduces desaturation during bronchoscopy under moderate to deep sedation with propofol and remifentanil: A randomised controlled clinical trial.
Zha B, Wu Z, Xie P, Xiong H, Xu L, Wei H. Zha B, et al. Eur J Anaesthesiol. 2021 Mar 1;38(3):294-301. doi: 10.1097/EJA.0000000000001401. Eur J Anaesthesiol. 2021. PMID: 33234777 Free PMC article. Clinical Trial.
BACKGROUND: Hypoxaemia is frequently seen during flexible bronchoscopies that are done with a nasal approach under the traditional sedation with propofol. This study investigated the potential benefits of supraglottic jet oxygenation and ventilation (SJOV) using the Wei na …
BACKGROUND: Hypoxaemia is frequently seen during flexible bronchoscopies that are done with a nasal approach under the traditional sedation …
Comparison of dexmedetomidine-propofol and ketamine-propofol administration during sedation-guided upper gastrointestinal system endoscopy.
Tekeli AE, Oğuz AK, Tunçdemir YE, Almali N. Tekeli AE, et al. Medicine (Baltimore). 2020 Dec 4;99(49):e23317. doi: 10.1097/MD.0000000000023317. Medicine (Baltimore). 2020. PMID: 33285707 Free PMC article. Clinical Trial.
We aimed to compare the effectiveness and safety of a dexmedetomidine-propofol combination and a ketamine-propofol combination during upper gastrointestinal system endoscopy. ...Patients who had severe organ disease, who had allergies to the study drugs, and who ref …
We aimed to compare the effectiveness and safety of a dexmedetomidine-propofol combination and a ketamine-propofol combination …
Effect of remifentanil and midazolam on ED95 of propofol for loss of consciousness in elderly patients: A randomized, clinical trial.
You AH, Kim JY, Kim DH, Suh J, Han DW. You AH, et al. Medicine (Baltimore). 2019 Apr;98(16):e15132. doi: 10.1097/MD.0000000000015132. Medicine (Baltimore). 2019. PMID: 31008935 Free PMC article. Clinical Trial.
BACKGROUND: Older people are more vulnerable to hemodynamic instability caused by propofol due to their decreased initial distribution volume and increased sensitivity to propofol. ...The patients were randomized into 3 groups using a computer-generated randomizatio …
BACKGROUND: Older people are more vulnerable to hemodynamic instability caused by propofol due to their decreased initial distributio …
Different sedation profiles with ciprofol compared to propofol represented by objective sedation level assessments by BIS and its acute hemodynamic impact in 3 escalated doses of ciprofol and propofol in healthy subjects: a single-center, open-label, randomized, 2-stage, 2-way crossover trial.
Deng J, Li MT, Yang MC, Wen ZM, Li XK, Zhu CY, Wang T, Yan T, Tang M, Pu Y, Zuo HY. Deng J, et al. Eur Rev Med Pharmacol Sci. 2023 Sep;27(17):7914-7923. doi: 10.26355/eurrev_202309_33550. Eur Rev Med Pharmacol Sci. 2023. PMID: 37750620 Free article. Clinical Trial.
PATIENTS AND METHODS: Eighteen subjects were planned to be enrolled into 3 dose groups in turn: group 1 (ciprofol-0.4 mg/kg vs. propofol-2.0 mg/kg), group 2 (ciprofol-0.6 mg/kg vs. propofol-3.0 mg/kg) and group 3 (ciprofol-0.8 mg/kg vs. propofol-4.0 mg/kg). T …
PATIENTS AND METHODS: Eighteen subjects were planned to be enrolled into 3 dose groups in turn: group 1 (ciprofol-0.4 mg/kg vs. propofol …
Differential effects of sevoflurane and propofol on an electroretinogram and visual evoked potentials.
Tanaka R, Tanaka S, Ichino T, Ishida T, Fuseya S, Kawamata M. Tanaka R, et al. J Anesth. 2020 Apr;34(2):298-302. doi: 10.1007/s00540-020-02733-7. Epub 2020 Jan 16. J Anesth. 2020. PMID: 31950267 Clinical Trial.
Propofol did not significantly decrease the amplitude of VEPs at Ce of 2 or 3 mug/ml but significantly decreased it at Ce of 4 mug/ml. In summary, propofol and sevoflurane at clinical concentrations had little effect on the amplitude of an ERG. ...
Propofol did not significantly decrease the amplitude of VEPs at Ce of 2 or 3 mug/ml but significantly decreased it at Ce of 4 mug/ml …
Effects of propofol and sevoflurane on T-cell immune function and Th cell differentiation in children with SMPP undergoing fibreoptic bronchoscopy.
Yu H, Chen L, Yue CJ, Xu H, Cheng J, Cornett EM, Kaye AD, Urits I, Viswanath O, Liu H. Yu H, et al. Ann Med. 2022 Dec;54(1):2574-2580. doi: 10.1080/07853890.2022.2121416. Ann Med. 2022. PMID: 36370066 Free PMC article. Clinical Trial.
Patients in the propofol group were anaesthetised with intravenous propofol and remifentanil. ...The ratio of Th(1)/Th(2) in the two groups was significantly increased postoperatively in both groups (Sevoflurane 8.53 vs 7.23, Propofol 9.35 vs 7.18), and the …
Patients in the propofol group were anaesthetised with intravenous propofol and remifentanil. ...The ratio of Th(1)/Th(2) in t …
7,009 results