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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1894 2
1945 1
1947 9
1948 18
1949 20
1950 40
1951 24
1952 32
1953 36
1954 59
1955 76
1956 75
1957 89
1958 84
1959 82
1960 92
1961 69
1962 126
1963 195
1964 198
1965 162
1966 171
1967 221
1968 279
1969 287
1970 295
1971 322
1972 353
1973 365
1974 465
1975 403
1976 354
1977 380
1978 369
1979 401
1980 493
1981 511
1982 600
1983 750
1984 789
1985 899
1986 974
1987 1013
1988 1064
1989 1196
1990 1517
1991 1275
1992 1384
1993 1354
1994 1368
1995 1312
1996 1404
1997 1443
1998 1566
1999 1628
2000 1678
2001 1846
2002 1955
2003 2339
2004 2511
2005 2715
2006 2972
2007 3154
2008 3144
2009 3240
2010 3365
2011 3538
2012 3593
2013 3569
2014 3473
2015 3352
2016 3272
2017 3244
2018 3272
2019 3261
2020 3188
2021 2999
2022 2554
2023 1894
2024 765

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91,292 results

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Page 1
Discovery, bioactivity and biosynthesis of fungal piperazines.
Wang R, Piggott AM, Chooi YH, Li H. Wang R, et al. Nat Prod Rep. 2023 Feb 22;40(2):387-411. doi: 10.1039/d2np00070a. Nat Prod Rep. 2023. PMID: 36374102 Review.
Since the first fungal piperazine, herquline A, was reported from Penicillium herquei Fg-372 in 1979, a plethora of structurally diverse piperazines have been isolated and characterised from various fungal strains. Significant advancements have been made in recent y …
Since the first fungal piperazine, herquline A, was reported from Penicillium herquei Fg-372 in 1979, a plethora of structurally dive …
Piperazine: A Promising Scaffold with Analgesic and Anti-inflammatory Potential.
Jain A, Chaudhary J, Khaira H, Chopra B, Dhingra A. Jain A, et al. Drug Res (Stuttg). 2021 Feb;71(2):62-72. doi: 10.1055/a-1323-2813. Epub 2020 Dec 17. Drug Res (Stuttg). 2021. PMID: 33336346 Review.
Piperazine, a nitrogen-containing heterocyclic has acquired an inimitable position in medicinal chemistry because of its versatile structure, which has fascinated researchers to design novel piperazine based molecules having various biological actions. ...Moreover, …
Piperazine, a nitrogen-containing heterocyclic has acquired an inimitable position in medicinal chemistry because of its versatile st …
Piperazine toxicity.
Darke PG. Darke PG. Vet Rec. 1987 May 23;120(21):507. doi: 10.1136/vr.120.21.507-a. Vet Rec. 1987. PMID: 3604015 No abstract available.
Recent advances in the synthesis of piperazine based ligands and metal complexes and their applications.
Kant R , Maji S . Kant R , et al. Dalton Trans. 2021 Jan 21;50(3):785-800. doi: 10.1039/d0dt03569f. Epub 2021 Jan 8. Dalton Trans. 2021. PMID: 33416816 Review.
The piperazine scaffold is a privileged structure frequently found in biologically active compounds. ...This is one of the reasons why piperazine based compounds are gaining prominence in today's research. ...
The piperazine scaffold is a privileged structure frequently found in biologically active compounds. ...This is one of the reasons wh …
Piperazine, a Key Substructure for Antidepressants: Its Role in Developments and Structure-Activity Relationships.
Kumar RR, Sahu B, Pathania S, Singh PK, Akhtar MJ, Kumar B. Kumar RR, et al. ChemMedChem. 2021 Jun 17;16(12):1878-1901. doi: 10.1002/cmdc.202100045. Epub 2021 Apr 7. ChemMedChem. 2021. PMID: 33751807 Review.
One peculiarity observed in most of the marketed antidepressants is the presence of a piperazine substructure. Although piperazine is also used in the optimization of other pharmacological agents, it is almost extensively used for the development of novel antidepres …
One peculiarity observed in most of the marketed antidepressants is the presence of a piperazine substructure. Although piperazine …
Preparation of piperazine.
MARTIN WB, MARTEL AE. MARTIN WB, et al. J Am Chem Soc. 1948 May;70(5):1817. doi: 10.1021/ja01185a049. J Am Chem Soc. 1948. PMID: 18861787 No abstract available.
An appraisal of anti-mycobacterial activity with structure-activity relationship of piperazine and its analogues: A review.
Girase PS, Dhawan S, Kumar V, Shinde SR, Palkar MB, Karpoormath R. Girase PS, et al. Eur J Med Chem. 2021 Jan 15;210:112967. doi: 10.1016/j.ejmech.2020.112967. Epub 2020 Oct 27. Eur J Med Chem. 2021. PMID: 33190957 Review.
Piperazine, is privileged six membered nitrogen containing heterocyclic ring also known as 1,4-Diazacyclohexane. Consequently, piperazine is a versatile medicinally important scaffold and is an essential core in numerous marketed drugs with diverse pharmacological a …
Piperazine, is privileged six membered nitrogen containing heterocyclic ring also known as 1,4-Diazacyclohexane. Consequently, pip …
Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 2.
Meanwell NA, Loiseleur O. Meanwell NA, et al. J Agric Food Chem. 2022 Sep 14;70(36):10972-11004. doi: 10.1021/acs.jafc.2c00729. Epub 2022 Jun 8. J Agric Food Chem. 2022. PMID: 35675052 Review.
Applications of piperazine and homopiperazine in drug design are well-established, and these heterocycles have found use as both scaffolding and terminal elements and also as a means of introducing a water-solubilizing element into a molecule. In the accompanying review (1 …
Applications of piperazine and homopiperazine in drug design are well-established, and these heterocycles have found use as both scaf …
Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 1.
Meanwell NA, Loiseleur O. Meanwell NA, et al. J Agric Food Chem. 2022 Sep 14;70(36):10942-10971. doi: 10.1021/acs.jafc.2c00726. Epub 2022 Jun 8. J Agric Food Chem. 2022. PMID: 35675050 Review.
In this review, we summarize the design and application of bioisosteres of piperazine and homopiperazine that have almost exclusively been in the drug design arena. While there are 100 approved drugs that incorporate a piperazine ring, only a single marketed agricul …
In this review, we summarize the design and application of bioisosteres of piperazine and homopiperazine that have almost exclusively …
The Recent Development of Piperazine and Piperidine Derivatives as Antipsychotic Agents.
Rathore A, Asati V, Kashaw SK, Agarwal S, Parwani D, Bhattacharya S, Mallick C. Rathore A, et al. Mini Rev Med Chem. 2021;21(3):362-379. doi: 10.2174/1389557520666200910092327. Mini Rev Med Chem. 2021. PMID: 32912125 Review.
When different heterocyclic groups are attached to basic piperidine and piperazine rings, the antipsychotic activity is greatly potentiated. ...In the present review, we include the studies related to the effect of different substituents on piperidine/piperazine der …
When different heterocyclic groups are attached to basic piperidine and piperazine rings, the antipsychotic activity is greatly poten …
91,292 results
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