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Page 1
Mecasermin.
Keating GM. Keating GM. BioDrugs. 2008;22(3):177-88. doi: 10.2165/00063030-200822030-00004. BioDrugs. 2008. PMID: 18481900 Review.
After 6.5-7.5 years of mecasermin therapy, the mean increase in the height standard deviation score was +1.4. ...Subcutaneous mecasermin was generally well tolerated in children with severe IGF-I deficiency associated with GH insensitivity....
After 6.5-7.5 years of mecasermin therapy, the mean increase in the height standard deviation score was +1.4. ...Subcutaneous meca …
Mecasermin rinfabate: rhIGF-I/rhIGFBP-3 complex: iPLEX.
Williams RM, McDonald A, O'Savage M, Dunger DB. Williams RM, et al. Expert Opin Drug Metab Toxicol. 2008 Mar;4(3):311-24. doi: 10.1517/17425255.4.3.311. Expert Opin Drug Metab Toxicol. 2008. PMID: 18363546 Review.
BACKGROUND: Mecasermin rinfabate (iPLEX), comprising rhIGF-I complexed to rhIGFBP-3, was developed in an attempt to prolong the half-life of IGF-I and potentially reduce side effects. ...CONCLUSIONS: The biological effects of Mecasermin rinfabate are largely similar …
BACKGROUND: Mecasermin rinfabate (iPLEX), comprising rhIGF-I complexed to rhIGFBP-3, was developed in an attempt to prolong the half- …
Mecasermin rinfabate.
Kemp SF. Kemp SF. Drugs Today (Barc). 2007 Mar;43(3):149-55. doi: 10.1358/dot.2007.43.3.1079876. Drugs Today (Barc). 2007. PMID: 17380212 Review.
Mecasermin rinfabate, a complex of equimolar amounts of insulin-like growth factor (IGF)-I and its binding protein IGFBP-3, has been approved by the U.S. ...In addition, the serum half-life of unbound rhIGF-I is shorter when administered to patients with growth hormone ins …
Mecasermin rinfabate, a complex of equimolar amounts of insulin-like growth factor (IGF)-I and its binding protein IGFBP-3, has been …
Molecular Signatures of Response to Mecasermin in Children With Rett Syndrome.
Shovlin S, Delepine C, Swanson L, Bach S, Sahin M, Sur M, Kaufmann WE, Tropea D. Shovlin S, et al. Front Neurosci. 2022 May 31;16:868008. doi: 10.3389/fnins.2022.868008. eCollection 2022. Front Neurosci. 2022. PMID: 35712450 Free PMC article.
However, improvements in corresponding clinical trials have not been consistent. A 20-weeks phase I open label trial of mecasermin (recombinant human IGF-1) in children with RTT demonstrated significant improvements in breathing phenotypes. ...Our analyses revealed gene ex …
However, improvements in corresponding clinical trials have not been consistent. A 20-weeks phase I open label trial of mecasermin (r …
Gut Microbiota and IGF-1.
Yan J, Charles JF. Yan J, et al. Calcif Tissue Int. 2018 Apr;102(4):406-414. doi: 10.1007/s00223-018-0395-3. Epub 2018 Jan 23. Calcif Tissue Int. 2018. PMID: 29362822 Free PMC article. Review.
Trofinetide: a pioneering treatment for Rett syndrome.
Parent H, Ferranti A, Niswender C. Parent H, et al. Trends Pharmacol Sci. 2023 Oct;44(10):740-741. doi: 10.1016/j.tips.2023.06.008. Epub 2023 Jul 16. Trends Pharmacol Sci. 2023. PMID: 37460385
Interestingly, clinical trials for recombinant human IGF-1 (mecasermin) in Rett syndrome patients yielded inconclusive results, which may reflect unique pharmacology or pharmacokinetics of trofinetide, warranting further investigation. ...
Interestingly, clinical trials for recombinant human IGF-1 (mecasermin) in Rett syndrome patients yielded inconclusive results, which …
Insulin-like growth factor-I deficiency in children with growth hormone insensitivity: current and future treatment options.
Kemp SF. Kemp SF. BioDrugs. 2009;23(3):155-63. doi: 10.2165/00063030-200923030-00002. BioDrugs. 2009. PMID: 19627167 Review.
Mecasermin has been shown to be effective in increasing height velocity and adult height in patients with severe GH resistance and in IGF1 gene deletion. There has been some interest in using mecasermin to treat patients with partial GH resistance or idiopathic shor …
Mecasermin has been shown to be effective in increasing height velocity and adult height in patients with severe GH resistance and in …
Mecasermin rinfabate: insulin-like growth factor-I/insulin-like growth factor binding protein-3, mecaserimin rinfibate, rhIGF-I/rhIGFBP-3.
[No authors listed] [No authors listed] Drugs R D. 2005;6(2):120-7. doi: 10.2165/00126839-200506020-00008. Drugs R D. 2005. PMID: 15777106 Review.
The comparative data will be included in the regulatory filing for mecasermin rinfabate. Mecasermin rinfabate was originally licensed to Welfide for Japan. ...This provides Insmed with 7 years of market exclusivity following approval of mecasermin rinfabate f …
The comparative data will be included in the regulatory filing for mecasermin rinfabate. Mecasermin rinfabate was originally l …
94 results