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Fosinopril/hydrochlorothiazide: single dose and steady-state pharmacokinetics and pharmacodynamics.
O'Grady P, Yee KF, Lins R, Mangold B. O'Grady P, et al. Br J Clin Pharmacol. 1999 Sep;48(3):375-81. doi: 10.1046/j.1365-2125.1999.00013.x. Br J Clin Pharmacol. 1999. PMID: 10510149 Free PMC article. Clinical Trial.
AIMS: Fosinoprilat, the active product of fosinopril, is eliminated by an hepatic pathway in addition to the renal pathway shared by other angiotensin converting enzyme inhibitors (ACEIs). ...This is probably due to the dual excretory pathways for fosinoprilat....
AIMS: Fosinoprilat, the active product of fosinopril, is eliminated by an hepatic pathway in addition to the renal pathway shared by …
Fosinopril and hydrochlorothiazide combination versus individual components: lack of a pharmacokinetic interaction.
Uderman HD, Much DR, Brennan J, Delaney CL, Morgenthien EA, Weaver J, Stouffer BC, Chang SY, VanHarken D, Liao W. Uderman HD, et al. Ann Pharmacother. 1999 May;33(5):525-30. doi: 10.1345/aph.18228. Ann Pharmacother. 1999. PMID: 10369612 Clinical Trial.
RESULTS: There was no evidence of any significant effect of HCTZ on the pharmacokinetics of fosinoprilat, based on maximum concentration value, AUC, or cumulative urinary recovery over 24 hours. Fosinoprilat had no clinically important effect on the pharmacokinetics …
RESULTS: There was no evidence of any significant effect of HCTZ on the pharmacokinetics of fosinoprilat, based on maximum concentrat …
Antihypertensive effect of fosinopril, a new angiotensin converting enzyme inhibitor: findings of the Fosinopril Study Group II.
Pool JL. Pool JL. Clin Ther. 1990 Nov-Dec;12(6):520-33. Clin Ther. 1990. PMID: 2149674 Clinical Trial.
No clinically significant abnormal laboratory test results were reported. Fosinoprilat, the active diacid of fosinopril, is eliminated by both the hepatobiliary and renal routes, which suggests that fosinopril may be particularly useful in the treatment of patients with im …
No clinically significant abnormal laboratory test results were reported. Fosinoprilat, the active diacid of fosinopril, is eliminate …