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Year Number of Results
1983 8
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1986 12
1987 21
1988 31
1989 14
1990 11
1991 9
1992 5
1993 3
1994 6
1995 3
1997 4
1998 4
1999 1
2000 1
2003 1
2006 1
2007 1
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2021 2
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Page 1
Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers.
Liu J, Zhai Y, Wu L, Wu G, Zheng Y, Hu X, Shentu J. Liu J, et al. Drug Des Devel Ther. 2020 Feb 13;14:613-620. doi: 10.2147/DDDT.S234619. eCollection 2020. Drug Des Devel Ther. 2020. PMID: 32103903 Free PMC article. Clinical Trial.
The objective of this study was to evaluate the pharmacokinetic profile and tolerability of single and multiple intravenous doses of cefotetan disodium in healthy Chinese volunteers. METHODS: In this single-center, open-label, dose-escalating study, subjects were randomize …
The objective of this study was to evaluate the pharmacokinetic profile and tolerability of single and multiple intravenous doses of cefo …
Pharmacokinetics and pharmacodynamics of total and unbound cefoxitin and cefotetan in healthy volunteers.
Carver PL, Nightingale CH, Quintiliani R. Carver PL, et al. J Antimicrob Chemother. 1989 Jan;23(1):99-106. doi: 10.1093/jac/23.1.99. J Antimicrob Chemother. 1989. PMID: 2745258 Clinical Trial.
We compared the pharmacokinetics and serum inhibitory activity of 2 g doses of cefotetan and cefoxitin in six healthy volunteers. The half-life of cefotetan (176 min) was significantly longer than that of cefoxitin (49 min). ...More studies comparing the clinical ou …
We compared the pharmacokinetics and serum inhibitory activity of 2 g doses of cefotetan and cefoxitin in six healthy volunteers. The …
Multicenter comparison of cefotetan and cefoxitin in the treatment of acute obstetric and gynecologic infections.
Hemsell DL, Wendel GD, Gall SA, Newton ER, Gibbs RS, Knuppel RA, Lane TW, Sweet RL. Hemsell DL, et al. Am J Obstet Gynecol. 1988 Mar;158(3 Pt 2):722-7. doi: 10.1016/s0002-9378(16)44535-7. Am J Obstet Gynecol. 1988. PMID: 3281462 Clinical Trial.
The mean duration of treatment was 5.2 and 5.4 days for the cefotetan and cefoxitin groups, respectively, and the total doses administered were 18.1 and 32.1 gm, respectively. The rate of clinical failure for the cefotetan group was 8.5% and 12.2% for the cefoxitin …
The mean duration of treatment was 5.2 and 5.4 days for the cefotetan and cefoxitin groups, respectively, and the total doses adminis …
In Vitro Activity of Cefotetan against ESBL-Producing Escherichia coli and Klebsiella pneumoniae Bloodstream Isolates from the MERINO Trial.
Stewart AG, Cottrell K, Henderson A, Vemuri K, Bauer MJ, Paterson DL, Harris PNA. Stewart AG, et al. Microbiol Spectr. 2021 Sep 3;9(1):e0022621. doi: 10.1128/Spectrum.00226-21. Epub 2021 Jul 7. Microbiol Spectr. 2021. PMID: 34232101 Free PMC article. Clinical Trial.
Presence of a narrow-spectrum OXA beta-lactamase did not appear to alter the cefotetan MIC distribution. Cefotetan demonstrated favorable in vitro efficacy against ESBL-producing E. coli and K. pneumoniae bloodstream isolates. ...Cefotetan holds potential to …
Presence of a narrow-spectrum OXA beta-lactamase did not appear to alter the cefotetan MIC distribution. Cefotetan demonstrate …
Cefotetan. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.
Ward A, Richards DM. Ward A, et al. Drugs. 1985 Nov;30(5):382-426. doi: 10.2165/00003495-198530050-00002. Drugs. 1985. PMID: 3905336 Review.
Cefotetan is a new semisynthetic cephamycin antibiotic administered intravenously or intramuscularly. ...An extended plasma elimination half-life of about 3.5 hours, and relatively high achievable serum and tissue levels, enables cefotetan to be administered on a tw …
Cefotetan is a new semisynthetic cephamycin antibiotic administered intravenously or intramuscularly. ...An extended plasma eliminati …
Comparison of cefotetan and cefoxitin prophylaxis for abdominal and vaginal hysterectomy.
Berkeley AS, Freedman KS, Ledger WJ, Orr JW, Benigno BB, Gordon SF, McGregor JA, Galask RP, Sevin BU. Berkeley AS, et al. Am J Obstet Gynecol. 1988 Mar;158(3 Pt 2):706-9. doi: 10.1016/s0002-9378(16)44531-x. Am J Obstet Gynecol. 1988. PMID: 3128112 Clinical Trial.
Prophylaxis was successful in 69 of 70 (98.6%) receiving cefotetan and 32 of 33 (97.0%) receiving cefoxitin who underwent vaginal hysterectomy. Prophylaxis was successful in 160 of 169 (94.7%) receiving cefotetan and in 79 of 83 (95.2%) receiving cefoxitin who under …
Prophylaxis was successful in 69 of 70 (98.6%) receiving cefotetan and 32 of 33 (97.0%) receiving cefoxitin who underwent vaginal hys …
Comparative effectiveness and safety of cefotetan and cefoxitin as prophylactic agents in patients undergoing abdominal or vaginal hysterectomy.
Berkeley AS, Orr JW, Cavanagh D, Freedman KS, Ledger WJ, Pastorek JG 2nd, Sevin BU. Berkeley AS, et al. Am J Surg. 1988 May 31;155(5A):81-5. doi: 10.1016/s0002-9610(88)80219-8. Am J Surg. 1988. PMID: 3287974 Clinical Trial.
A successful clinical response occurred in 92 percent of those receiving cefotetan and 90 percent of those receiving cefoxitin who underwent abdominal hysterectomy, and in 94 percent of those receiving cefotetan and 93 percent of those receiving cefoxitin who underw …
A successful clinical response occurred in 92 percent of those receiving cefotetan and 90 percent of those receiving cefoxitin who un …
A comparative trial between cefotetan and cephazolin for wound sepsis prophylaxis during elective upper gastrointestinal surgery with an investigation of cefotetan penetration into the obstructed biliary tree.
Leaper DJ, Cooper MJ, Turner A. Leaper DJ, et al. J Hosp Infect. 1986 May;7(3):269-76. doi: 10.1016/0195-6701(86)90077-0. J Hosp Infect. 1986. PMID: 2873173 Clinical Trial.
Cefotetan is a cephamycin antibiotic theoretically suited to prophylaxis of wound infection during upper elective gastrointestinal surgery. In a prophylaxis trial 100 patients undergoing this type of surgery were randomly allocated to receive 1g cefotetan or cephazo …
Cefotetan is a cephamycin antibiotic theoretically suited to prophylaxis of wound infection during upper elective gastrointestinal su …
Multicenter open trial of cefotetan and cefoxitin in elective biliary surgery.
Fabian TC, Zellner SR, Gazzaniga A, Hanna C, Nichols RL, Waxman K. Fabian TC, et al. Am J Surg. 1988 May 31;155(5A):77-80. doi: 10.1016/s0002-9610(88)80218-6. Am J Surg. 1988. PMID: 3287973 Clinical Trial.
Common duct exploration was performed in 6 percent of the 2 g cefotetan patients, 9 percent in the 1 g cefotetan patients, and 13 percent in the 2 g cefoxitin patients. ...The clinical success rates were 98 percent in the 2 g cefotetan patients, 98 percent in …
Common duct exploration was performed in 6 percent of the 2 g cefotetan patients, 9 percent in the 1 g cefotetan patients, and …
Absolute bioavailability and noncompartmental analysis of intravenous and intramuscular Cefotan (cefotetan) in normal volunteers.
Zimmerman J, Cohen A, Thyrum P. Zimmerman J, et al. J Clin Pharmacol. 1989 Feb;29(2):151-7. doi: 10.1002/j.1552-4604.1989.tb03304.x. J Clin Pharmacol. 1989. PMID: 2715372 Clinical Trial.
Cefotetan (1 g) was administered to 12 normal volunteers as a 30 minute intravenous infusion and as an intramuscular injection. ...Cefotetan tautomer was detected in the plasma and urine of all subjects after both routes of administration, but the mean concentration …
Cefotetan (1 g) was administered to 12 normal volunteers as a 30 minute intravenous infusion and as an intramuscular injection. ... …
150 results