Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 1
2007 3
2008 2
2009 3
2010 3
2011 8
2012 5
2013 1
2014 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

24 results

Results by year

Filters applied: . Clear all
Page 1
Aliskiren, amlodipine and hydrochlorothiazide triple combination for hypertension.
Judd E, Jaimes EA. Judd E, et al. Expert Rev Cardiovasc Ther. 2012 Mar;10(3):293-303. doi: 10.1586/erc.12.7. Expert Rev Cardiovasc Ther. 2012. PMID: 22390800 Free PMC article. Review.
Single-pill triple combinations have returned to the market following results of increased efficacy and adherence over dual- and mono-therapy. The combination of aliskiren, amlodipine and hydrochlorothiazide is a rational choice for combination therapy and recent studies s …
Single-pill triple combinations have returned to the market following results of increased efficacy and adherence over dual- and mono-therap …
The single pill triple combination of aliskiren, amlodipine, and hydrochlorothiazide in the treatment of hypertension.
Huan Y, Townsend R. Huan Y, et al. Expert Opin Pharmacother. 2012 Nov;13(16):2409-15. doi: 10.1517/14656566.2012.736492. Expert Opin Pharmacother. 2012. PMID: 23067322 Review.
Combination therapy with antihypertensive agents of complementary actions has been advocated in the management of hypertension to maximize efficacy and minimize side effects. AREAS COVERED: This review summarizes the current data on the triple combination therapy of ali …
Combination therapy with antihypertensive agents of complementary actions has been advocated in the management of hypertension to maximize e …
Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy.
Sureshkumar KK. Sureshkumar KK. Vasc Health Risk Manag. 2008;4(6):1205-20. doi: 10.2147/vhrm.s3364. Vasc Health Risk Manag. 2008. PMID: 19337534 Free PMC article. Review.
Studies have shown equivalent antihypertensive efficacy of aliskiren when compared to existing medications such as HCTZ, ACE inhibitors and ARBs. Aliskiren has also been tested in combination therapies. The current review aims to look at the efficacy of aliskiren …
Studies have shown equivalent antihypertensive efficacy of aliskiren when compared to existing medications such as HCTZ, ACE inhibito …
Safety and efficacy of aliskiren/amlodipine/hydrochlorothiazide triple combination in patients with moderate to severe hypertension: a 54-week, open-label study.
Murray AV, Koenig W, Garcia-Puig J, Patel S, Uddin A, Zhang J. Murray AV, et al. J Clin Hypertens (Greenwich). 2012 Dec;14(12):821-7. doi: 10.1111/j.1751-7176.2012.00706.x. Epub 2012 Aug 28. J Clin Hypertens (Greenwich). 2012. PMID: 23205748 Free PMC article. Clinical Trial.
This 28- to 54-week, open-label, multicenter study evaluated the safety and efficacy of a triple combination, aliskiren with amlodipine and hydrochlorothiazide (HCTZ), in patients with moderate to severe hypertension. Following a washout period of up to 4 weeks, patients r …
This 28- to 54-week, open-label, multicenter study evaluated the safety and efficacy of a triple combination, aliskiren with amlodipi …
Comparison of aliskiren/hydrochlorothiazide combination therapy and amlodipine monotherapy in patients with stage 2 systolic hypertension and type 2 diabetes mellitus.
Townsend RR, Forker AD, Bhosekar V, Yadao A, Keefe DL. Townsend RR, et al. J Clin Hypertens (Greenwich). 2011 Dec;13(12):889-97. doi: 10.1111/j.1751-7176.2011.00552.x. Epub 2011 Nov 11. J Clin Hypertens (Greenwich). 2011. PMID: 22142348 Free PMC article. Clinical Trial.
Patients received either once-daily aliskiren/HCTZ 150/12.5 mg or amlodipine 5 mg for 1 week then force-titrated to double the doses for 7 weeks. ...Mean sitting diastolic BP reductions were similar with aliskiren/HCTZ (9.9 mm Hg) and amlodipine (9.0 mm Hg). Achieve …
Patients received either once-daily aliskiren/HCTZ 150/12.5 mg or amlodipine 5 mg for 1 week then force-titrated to double the doses …
Long-term safety and efficacy of aliskiren and valsartan combination with or without the addition of HCT in patients with hypertension.
Chrysant SG, Murray AV, Hoppe UC, Dattani D, Patel S, Ritter S, Zhang J. Chrysant SG, et al. Curr Med Res Opin. 2010 Dec;26(12):2841-9. doi: 10.1185/03007995.2010.528282. Epub 2010 Nov 9. Curr Med Res Opin. 2010. PMID: 21062137 Clinical Trial.
Of the 486 patients completed the core study, 180 patients entered the extension phase and received aliskiren/valsartan and add-on HCT (12.5 or 25 mg). Overall the combination of aliskiren/valsartan was well-tolerated and the majority of AEs were mild-to-moderate in …
Of the 486 patients completed the core study, 180 patients entered the extension phase and received aliskiren/valsartan and add-on HC …
Pharmacokinetics and pharmacodynamics of aliskiren/hydrochlorothiazide single-pill combination tablets and free combination of aliskiren and hydrochlorothiazide.
Yan JH, Jarugula V, Sabo R, Papst CC, Zhang J, Dole WP. Yan JH, et al. J Clin Pharmacol. 2012 May;52(5):645-55. doi: 10.1177/0091270011405499. Epub 2011 Jun 9. J Clin Pharmacol. 2012. PMID: 21659626 Clinical Trial.
Aliskiren/HCT 300/25 mg SPC inhibited PRA to the same extent as the free combination. ...In conclusion, aliskiren/HCT SPCs are pharmacokinetically and pharmacodynamically bioequivalent to aliskiren and HCT in free combination....
Aliskiren/HCT 300/25 mg SPC inhibited PRA to the same extent as the free combination. ...In conclusion, aliskiren/HCT SPCs are …
Efficacy and tolerability of aliskiren 300 mg/hydrochlorothiazide 25 mg ( amlodipine 5 mg) in hypertensive patients not controlled by candesartan 32 mg plus HCT 25 mg.
Schweizer J, Ulmer HJ, Benduhn H, Klebs S. Schweizer J, et al. Curr Med Res Opin. 2011 Jan;27(1):131-40. doi: 10.1185/03007995.2010.537318. Epub 2010 Nov 30. Curr Med Res Opin. 2011. PMID: 21117946 Clinical Trial.
We aimed to investigate whether the single-pill combination of aliskiren 300 mg and hydrochlorothiazide (HCT) 25 mg (ALIS 300/HCT 25) improves the BP reduction in hypertensive patients not adequately controlled by the free combination of candesartan 32 mg and HCT 25 mg (CA …
We aimed to investigate whether the single-pill combination of aliskiren 300 mg and hydrochlorothiazide (HCT) 25 mg (ALIS 300/HCT 25) …
Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide.
Schmieder RE, Philipp T, Guerediaga J, Gorostidi M, Smith B, Weissbach N, Maboudian M, Botha J, van Ingen H. Schmieder RE, et al. Circulation. 2009 Jan 27;119(3):417-25. doi: 10.1161/CIRCULATIONAHA.107.750745. Epub 2009 Jan 12. Circulation. 2009. PMID: 19139391 Clinical Trial.
Adverse event rates were similar with aliskiren- (65.2%) and hydrochlorothiazide-based therapy (61.5%). ...Aliskiren-based therapy was well tolerated. Direct renin inhibition with aliskiren therefore represents an effective option for the long-term tre …
Adverse event rates were similar with aliskiren- (65.2%) and hydrochlorothiazide-based therapy (61.5%). ...Aliskiren-ba …
Efficacy and safety of aliskiren-based dual and triple combination therapies in US minority patients with stage 2 hypertension.
Ferdinand KC, Weitzman R, Israel M, Lee J, Purkayastha D, Jaimes EA. Ferdinand KC, et al. J Am Soc Hypertens. 2011 Mar-Apr;5(2):102-13. doi: 10.1016/j.jash.2011.01.006. J Am Soc Hypertens. 2011. PMID: 21414565 Clinical Trial.
In this 8-week double-blind study, 412 patients were randomized to receive aliskiren/amlodipine (150/5 mg) or amlodipine (5 mg) with forced titration up to aliskiren/amlodipine/HCTZ (300/10/25 mg) or aliskiren/amlodipine (300/10 mg), respectively. ...Mean sit …
In this 8-week double-blind study, 412 patients were randomized to receive aliskiren/amlodipine (150/5 mg) or amlodipine (5 mg) with …
24 results