Abstract
Two new sesquiterpenoids, (-)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (-)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3-8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenosine Diphosphate / pharmacology
-
Animals
-
Anti-Bacterial Agents* / chemistry
-
Anti-Bacterial Agents* / isolation & purification
-
Anti-Bacterial Agents* / pharmacology
-
Bacteria / growth & development*
-
Blood Platelets / cytology
-
Blood Platelets / metabolism*
-
Leonurus / chemistry*
-
Plants, Medicinal / chemistry*
-
Platelet Aggregation / drug effects*
-
Rats
-
Rats, Sprague-Dawley
-
Sesquiterpenes* / chemistry
-
Sesquiterpenes* / isolation & purification
-
Sesquiterpenes* / pharmacology
Substances
-
Anti-Bacterial Agents
-
Sesquiterpenes
-
Adenosine Diphosphate