Abstract
From the ethyl acetate extract of the culture broth of Talaromyces verruculosus, a rhizosphere fungus of Stellera chamaejasme L., (-)-8-hydroxy-3-(4-hydroxypentyl)-3,4-dihydroisocoumarin (1) and (E)-3-(2,5-dioxo-3-(propan-2-ylidene)pyrrolidin-1-yl)acrylic acid (2) were isolated and evaluated for their antimicrobial activities. Their structures were elucidated by UV, IR, MS, 1H-NMR, 13C-NMR and 2D NMR spectra. Compound 1 exhibited the significant activities in vitro against two strains of bacteria and four strains of fungi. Compound 2 gave slight activities on the fungi at 100 µg mL(-1), but no activities on the bacteria. Compound 1 should be considered as a new lead or model compound to develop new isocoumarin antimicrobial agents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylates / chemistry*
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Anti-Infective Agents* / chemistry
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Anti-Infective Agents* / isolation & purification
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Anti-Infective Agents* / metabolism
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Bacteria / drug effects
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Coumarins / chemistry*
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Coumarins / isolation & purification
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Coumarins / pharmacology
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Fungi / drug effects
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Isocoumarins
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Structure
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Pyrrolidines / chemistry*
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Pyrrolidines / isolation & purification
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Pyrrolidines / pharmacology
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Talaromyces* / chemistry
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Talaromyces* / metabolism
Substances
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(-)-8-hydroxy-3-(4-hydroxypentyl)-3,4-dihydroisocoumarin
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(E)-3-(2,5-dioxo-3-(propan-2-ylidene)pyrrolidin-1-yl)acrylic acid
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Acrylates
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Anti-Infective Agents
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Coumarins
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Isocoumarins
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Pyrrolidines
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coumarin
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pyrrolidine