Oxime esters of 2,6-diazaanthracene-9,10-dione and 4,5-diazafluoren-9-one as photo-induced DNA-cleaving agents

Molecules. 2012 Mar 15;17(3):3370-82. doi: 10.3390/molecules17033370.

Abstract

Two series of oxime esters containing the 2,6-diazaanthracene-9,10-dione bis-(O-benzoyloxime) and 4,5-diazafluoren-9-one O-9-benzoyloxime moieties have been synthesized and tested as photo-induced DNA cleaving agents. All these compounds were found to cleave DNA upon irradiation with 312 nm UV light. The structure-activity relationship of these molecules for DNA cleavage was established. A plausible reaction mechanism is also proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthracenes / chemistry*
  • DNA Cleavage / radiation effects*
  • Fluorenes
  • Light*
  • Molecular Structure
  • Pyridines / chemistry*
  • Structure-Activity Relationship

Substances

  • 4,5-diazafluoren-9-one
  • Anthracenes
  • Fluorenes
  • Pyridines
  • anthracene