Isolation of C₁₁ compounds and a cyclopropane fatty acid from an Okinawan ascidian, Diplosoma sp

Tamanna Rob; Takayuki Ogi; Wilmar Maarisit; Junsei Taira; Katsuhiro Ueda

doi:10.3390/molecules16129972

Isolation of C₁₁ compounds and a cyclopropane fatty acid from an Okinawan ascidian, Diplosoma sp

Molecules. 2011 Dec 2;16(12):9972-82. doi: 10.3390/molecules16129972.

Authors

Tamanna Rob¹, Takayuki Ogi, Wilmar Maarisit, Junsei Taira, Katsuhiro Ueda

Affiliation

¹ Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho Okinawa 903-0123, Japan.

Abstract

Pentylphenols 1 and 2, cyclopropane fatty acid 3, and cyclopentenones 4 and 5, were isolated from an ascidian, Diplosoma sp. The structures of 1-5 were determined by spectroscopic analysis and/or synthesis. Compound 1 inhibited the division of fertilized sea urchin eggs and compound 4 showed mild cytotoxity against HCT116 cells (human colorectal cancer cell).

MeSH terms

Animals
Cyclopropanes / chemistry
Cyclopropanes / isolation & purification*
Cyclopropanes / pharmacology
Fatty Acids / chemistry
Fatty Acids / isolation & purification*
Fatty Acids / pharmacology
HCT116 Cells
Humans
Japan
Magnetic Resonance Spectroscopy
Organic Chemicals / chemistry
Organic Chemicals / isolation & purification*
Organic Chemicals / pharmacology
Sea Urchins / cytology
Sea Urchins / drug effects
Urochordata / chemistry*

Substances

Cyclopropanes
Fatty Acids
Organic Chemicals
cyclopropane fatty acids