Abstract
Four new eunicellin-based diterpenoids, krempfielins A-D (1-4), along with two known compounds (5 and 6) have been isolated from a soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 5 and 6 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 2, 3, 5 and 6 were shown to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells.
Keywords:
Cladiella krempfi; anti-inflammatory activity; cytotoxic activity; eunicellin-based diterpenoids; krempfielins; soft coral.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Biological Products / chemistry
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Biological Products / isolation & purification
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Biological Products / pharmacology*
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Cell Line, Tumor
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Cytotoxins / chemistry
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Cytotoxins / isolation & purification
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Cytotoxins / pharmacology
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Furans / chemistry
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Furans / isolation & purification
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Furans / pharmacology*
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Humans
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Indoles / chemistry
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Indoles / isolation & purification
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Indoles / pharmacology*
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Magnetic Resonance Spectroscopy
Substances
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2-(ethylthio)ethyl 6-(furan-2-yl)-3-methyl-4-oxo-4,5,6,7,tetrahydro-1H-indole-2-carboxylate
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Biological Products
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Cytotoxins
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Diterpenes
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Furans
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Indoles
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krempfielin B
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krempfielin C