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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 58-05-9
Drug Levels and Effects
Summary of Use during Lactation
Leucovorin (folinic acid; 5-formyltetrahydrofolic acid) and its levo- isomer, levoleucovorin, are folic acid derivatives that are normal components of breastmilk.[1,2] Because leucovorin and levoleucovorin are used as therapeutic agents with potentially toxic drugs such as fluorouracil or methotrexate, the LactMed record of the drug it is used with should be consulted.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Page R, Robichaud A, Arbuckle TE, et al. Total folate and unmetabolized folic acid in the breast milk of a cross-section of Canadian women. Am J Clin Nutr 2017;105:1101-9. [PubMed: 28298392]
- 2.
- Su Y, Mao Y, Tian F, et al. Profile of folate in breast milk from Chinese women over 1-400 days postpartum. Nutrients 2022;14:2962. [PMC free article: PMC9319857] [PubMed: 35889919]
Substance Identification
Substance Name
Leucovorin
CAS Registry Number
58-05-9
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review Levoleucovorin as replacement for leucovorin in cancer treatment.[Ann Pharmacother. 2012]Review Levoleucovorin as replacement for leucovorin in cancer treatment.Chuang VT, Suno M. Ann Pharmacother. 2012 Oct; 46(10):1349-57. Epub 2012 Oct 2.
- Review Common vitamin B complex agents and folic acid: Part IV. Leucovorin calcium (citrovorum factor, folinic acid [wellcovorin]).[Gastroenterol Nurs. 1997]Review Common vitamin B complex agents and folic acid: Part IV. Leucovorin calcium (citrovorum factor, folinic acid [wellcovorin]).Claussen DW. Gastroenterol Nurs. 1997 May-Jun; 20(3):107-8.
- Review Incompatibility of fluorouracil with leucovorin calcium or levoleucovorin calcium.[Am J Health Syst Pharm. 1995]Review Incompatibility of fluorouracil with leucovorin calcium or levoleucovorin calcium.Trissel LA, Martinez JF, Xu QA. Am J Health Syst Pharm. 1995 Apr 1; 52(7):710-5.
- Review Is levoleucovorin an alternative to racemic leucovorin? A literature review.[Clin Colorectal Cancer. 2009]Review Is levoleucovorin an alternative to racemic leucovorin? A literature review.Kovoor PA, Karim SM, Marshall JL. Clin Colorectal Cancer. 2009 Oct; 8(4):200-6.
- Parallel administration of nanoliposomal irinotecan and levo-leucovorin for pancreatic cancer.[BMC Cancer. 2023]Parallel administration of nanoliposomal irinotecan and levo-leucovorin for pancreatic cancer.Takada R, Ikezawa K, Yamai T, Watsuji K, Seiki Y, Kawamoto Y, Hirao T, Higashi S, Urabe M, Kai Y, et al. BMC Cancer. 2023 Jul 31; 23(1):711. Epub 2023 Jul 31.
- Leucovorin - Drugs and Lactation Database (LactMed®)Leucovorin - Drugs and Lactation Database (LactMed®)
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