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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
Drug Levels and Effects
Summary of Use during Lactation
The Centers for Disease Control and Prevention and several health professional organizations state that vaccines given to a nursing mother do not affect the safety of breastfeeding for mothers or infants and that breastfeeding is not a contraindication to meningococcal vaccine. Immunization of the mother during the third trimester of pregnancy markedly increases the amount of meningococcal antibodies in breastmilk.[1] Breastfed infants should be vaccinated according to the routine recommended schedules.[2-4]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Limited data indicate that breastfeeding can enhance the response of the infant to certain vaccine antigens.[2,3,5]
Immunization of pregnant or lactating women with meningococcal vaccine increased the specific secretory IgA content of milk.[6,7]
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Maertens K, De Schutter S, Braeckman T, et al. Breastfeeding after maternal immunisation during pregnancy: Providing immunological protection to the newborn: A review. Vaccine. 2014;32:1786–92. [PubMed: 24530929]
- 2.
- Ezeanolue E, Harriman K, Hunter P, et al. Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP). https://www
.cdc.gov/vaccines /hcp/acip-recs /general-recs/index.html Accessed June 5, 2020. - 3.
- Kimberlin DW, Brady MT, Jackson MA, et al. Red Book: 2018 Report of the Committee on Infectious Diseases. 31st ed. Elk Grove Village, IL: American Academy of Pediatrics. 2018.
- 4.
- Gruslin A, Steben M, Halperin S, et al. Immunization in pregnancy: No. 220, December 2008. Int J Gynaecol Obstet. 2009;105:187–91. [PubMed: 19367691]
- 5.
- Pabst HF. Immunomodulation by breast-feeding. Pediatr Infect Dis J. 1997;16:991–5. [PubMed: 9380478]
- 6.
- Lakshman R, Seymour L, Akhtar S, et al. Secretory antibody responses to quadrivalent meningococcal vaccine in lactating mothers. Clin Infect Dis. 2000;31:321. Abstract 629.
- 7.
- Shahid NS, Steinhoff MC, Roy E, et al. Placental and breast transfer of antibodies after maternal immunization with polysaccharide meningiococcal vaccine: a randomized, controlled evaluation. Vaccine. 2002;20:2404–9. [PubMed: 12009297]
Substance Identification
Substance Name
Meningococcal Vaccines
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review Pneumococcal Vaccines.[Drugs and Lactation Database (...]Review Pneumococcal Vaccines.. Drugs and Lactation Database (LactMed®). 2006
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- MenQuadfi - a new meningococcal (A, C, W, and Y) vaccine.[Med Lett Drugs Ther. 2021]MenQuadfi - a new meningococcal (A, C, W, and Y) vaccine.. Med Lett Drugs Ther. 2021 May 17; 63(1624):78-80.
- Improving meningococcal MenACWY and 4CMenB/meningococcal group B vaccine-related health literacy in patients: Importance of readability of pharmaceutical Patient Leaflets.[J Clin Pharm Ther. 2021]Improving meningococcal MenACWY and 4CMenB/meningococcal group B vaccine-related health literacy in patients: Importance of readability of pharmaceutical Patient Leaflets.Brennan OC, Moore JE, Nutt TW, Moore PJ, Millar BC. J Clin Pharm Ther. 2021 Aug; 46(4):1109-1116. Epub 2021 Mar 25.
- Review Diphtheria-Tetanus-Pertussis Vaccines.[Drugs and Lactation Database (...]Review Diphtheria-Tetanus-Pertussis Vaccines.. Drugs and Lactation Database (LactMed®). 2006
- Meningococcal Vaccines - Drugs and Lactation Database (LactMed®)Meningococcal Vaccines - Drugs and Lactation Database (LactMed®)
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