Table 10Overdiagnosis and Overtreatment in Studies of Age to Stop Screening in an Emulated Trial, by Population Subgroup

Author, Year

Study/Trial Name

Comparison (IG vs. CG)PopulationOutcome CategoryOutcome DefinitionIG Proportion (95% CI)CG Proportion (95% CI)
Garcia-Albeniz, 2020136Continued screening after age 70 vs. cessation of screeningWomen ages 70 to 74 years with a life expectancy of at least 10 yearsIncidence8-year cumulative risk of breast cancer diagnosis5.3 (NR)3.9 (NR)
Treatments received by women diagnosed with breast cancer*Lumpectomy52.6 (51.8–53.4)36.5 (35.2–38.0)
Simple mastectomy11.3 (10.8–11.8)10.4 (9.5–11.3)
Radical mastectomy13.9 (13.4–14.5)18.2 (17.0–19.4)
Radiotherapy51.0 (50.3–51.8)39.9 (38.6–41.3)
Chemotherapy15.2 (14.7–15.8)21.1 (20.0–22.1)
Continued screening after age 75 vs. cessation of screeningWomen ages 75 to 84 years with a life expectancy of at least 10 yearsIncidence8-year cumulative risk of breast cancer diagnosis5.8 (NR)3.9 (NR)
Treatments received by women diagnosed with breast cancer*Lumpectomy48.8 (47.9–49.5)32.6 (31.5–33.8)
Simple mastectomy10.8 (10.3–11.2)10.1 (9.4–10.9)
Radical mastectomy14.2 (13.7–14.6)17.0 (16.0–17.9)
Radiotherapy41.2 (40.4–41.9)31.9 (30.7–33.1)
Chemotherapy8.6 (8.3–9.1)11.5 (10.6–12.3)
*

Percentages are standardized to the age group–specific distribution of age; comorbidity score; new diagnosis of Alzheimer disease, acute myocardial infarction, chronic heart failure, chronic kidney disease, chronic obstructive pulmonary disease, hip fracture, stroke, or cancer (lung, endometrial, or colorectal); and institutionalization in a long-term care center.

Abbreviations: CG=control group; CI=confidence interval; IG=intervention group; NR=not reported

From: Chapter 3, Results

Cover of Screening for Breast Cancer: A Comparative Effectiveness Review for the U.S. Preventive Services Task Force
Screening for Breast Cancer: A Comparative Effectiveness Review for the U.S. Preventive Services Task Force [Internet].
Evidence Synthesis, No. 231.
Henderson JT, Webber EM, Weyrich M, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.