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Butler M, Urosevic S, Desai P, et al. Treatment for Bipolar Disorder in Adults: A Systematic Review [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2018 Aug. (Comparative Effectiveness Review, No. 208.)

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Treatment for Bipolar Disorder in Adults: A Systematic Review [Internet].

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Table 1FDA-approved medications for bipolar disorder

Drug TypeGeneric Name First Date ApprovedFDA –Listed Trade Name (Pharmaceutical Co.)ManicMixed (Mania/Depression)Mainte-nanceDepression
SaltsLithium 1970XX
Atypical AntipsychoticsAripiprazole 2004Abilify (Otsuka)XXX
Asenapine 2015Saphris (Organon Sub Merck)XX
Cariprazine 2015Vraylar (Forest
Lurasidone 2013Latuda (Sunovion Pharms)X
Olanzapine* 2000Zyprexa (Lilly)XXX
Olanzapine/fluoxetine combination* 2012Symbyax (Lilly)X
Quetiapine 2004Seroquel (AstraZeneca)XX
Risperidone 2003Risperdal (Janssen Pharm)XX
Ziprasidone 2004Geodon (Pfizer)XX
AnticonvulsantsCarbamazepine* 2004Carbetrol (Shire), Epitol (TEVA), Equetro (Validus Pharms), Tegretol (Novartis), Teril (Taro)XX
Lamotrigine* 2003Lamictal (GlaxoSmithKline)X
Divalproex sodium* or valproate 1995Depakote (ABBVIE)X
Lamotrigine* 2003Lamictal (GlaxoSmithKline)X
*

Generic forms are available. FDA=Food and Drug Administration

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