DataSet Record GDS4756: Expression Profiles Data Analysis Tools Sample Subsets
Title: Bone marrow microenvironment effect on imatinib-treated chronic myeloid leukemia CD34+ cells
Cluster AnalysisGDS4756 Cluster Image
Summary: Analysis of CML cells treated with tyrosine kinase inhibitor (TKI) imatinib and BM mesenchymal stromal cells (MSCs). Coculture with MSCs protects the CML cells from TKI-mediated cell death and depletion. Results provide insight into microenvironmental protection of CML cells from TKI treatment.
Organism: Homo sapiens
Platform: GPL6244: [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
  • Zhang B, Li M, McDonald T, Holyoake TL et al. Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling. Blood 2013 Mar 7;121(10):1824-38. PMID: 23299311
Reference Series: GSE43225 Sample count: 12
Value type: transformed count Series published: 2013/01/01