Proteasome inhibitor Bortezomib or proteasome subunit knockdown effect on MCF7 breast cancer cells
Summary:
Analysis of MCF7 cells stimulated with bortezomib or depleted of PSMB3 or PSMB5. Proteasome inhibition can regulate estrogen-induced transcription. Results provide insight into mechanisms by which proteasome inhibition influences ERα function and into improved strategies for breast cancer treatment
GPL14010:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [hugene10stv1hsentrezg]
Citation:
Prenzel T, Begus-Nahrmann Y, Kramer F, Hennion M et al. Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B. Cancer Res 2011 Sep 1;71(17):5739-53. PMID: 21862633
