Interferon regulatory factor 6 null mutation effect on the skin
Summary:
Analysis of skins of interferon regulatory factor 6 (IRF6) null mutants at embryonic day 17.5. Genetic variations in IRF6 are associated with cleft lip and palate in humans. Results provide insight into the role of IRF6 in epidermal development.
Ingraham CR, Kinoshita A, Kondo S, Yang B et al. Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6). Nat Genet 2006 Nov;38(11):1335-40. PMID: 17041601