Age effect on livers of long-lived Snell dwarf mutants
Summary:
Analysis of livers from 6 and 22-month-old Snell dwarf mice which live 40% longer than wild types. Snell animals have a mutation in the Pit1 gene which prevents the development of anterior pituitary cells that produce growth hormone, thyroid stimulating hormone, and prolactin.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Boylston WH, DeFord JH, Papaconstantinou J. Identification of longevity-associated genes in long-lived Snell and Ames dwarf mice. Age (Dordr) 2006 Jun;28(2):125-44. PMID: 19943135
