DataSet Record GDS170: Expression Profiles Data Analysis Tools Sample Subsets
Title: Tumor suppressor protein p53 gene dosage effects
Cluster AnalysisGDS170 Cluster Image
Summary: Analysis of tumor suppressor protein p53 gene dosage effects in HCT116 colorectal carcinoma-derived cell lines p53 -/-, +/- and +/+ at 0 and 12 hours. Cells with different numbers of functional TP53 alleles can be distinguished by gene expression profile.
Organism: Homo sapiens
Platform: GPL80: [Hu6800] Affymetrix Human Full Length HuGeneFL Array
  • Yoon H, Liyanarachchi S, Wright FA, Davuluri R et al. Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53. Proc Natl Acad Sci U S A 2002 Nov 26;99(24):15632-7. PMID: 12438652
Reference Series: GSE90 Sample count: 12
Value type: count Series published: 2002/11/25