Transcription factor HNF4 null mutation effect on fetal colon
Summary:
Analysis of epithelial cells from colon lacking hepatocyte nuclear factor 4 (HNF4) from embryos at E18.5. HNF4 encodes a nuclear hormone receptor transcription factor required for hepatocyte differentiation and liver development. Results provide insight into the role of HNF4 in colon development.
Garrison WD, Battle MA, Yang C, Kaestner KH et al. Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology 2006 Apr;130(4):1207-20. PMID: 16618389