Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior
Summary:
Analysis of aged brain after activation of the peripheral innate immune system by intraperitoneal injection of E. coli lipopolysaccharide (LPS). Results provide insight into molecular events underlying severe behavioral deficits (delirium) common in older adults with systemic infections.
Godbout JP, Chen J, Abraham J, Richwine AF et al. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J 2005 Aug;19(10):1329-31. PMID: 15919760
