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News: Bacteria Harbor Geometric “Organelles” (The Scientist) - Behind the headlines

In the news

Media coverage of health and science topics

The Scientist Dec. 1, 2018

Bacteria Harbor Geometric “Organelles”

Microbes, traditionally thought to lack organelles, get a metabolic boost from geometric compartments that act as cauldrons for chemical reactions. Bioengineers are eager to harness the compartments for their own purposes.

Read more at The Scientist

Behind the headlines

Research findings and data from the National Library of Medicine

PubMed articles

ACS Synth Biol FEB. 24, 2014

Solution structure of a bacterial microcompartment targeting peptide and its application in the construction of an ethanol bioreactor

AD Lawrence et al

Targeting of proteins to bacterial microcompartments (BMCs) is mediated by an 18-amino-acid peptide sequence. Herein, we report the solution structure of the N-terminal t …

Nat Commun MAY 18, 2018

Bacterial encapsulins as orthogonal compartments for mammalian cell engineering

F Sigmund et al

We genetically controlled compartmentalization in eukaryotic cells by heterologous expression of bacterial encapsulin shell and cargo proteins to engineer enclosed enzyma …

Nat Commun JULY 23, 2018

Programmed loading and rapid purification of engineered bacterial microcompartment shells

A Hagen et al

Bacterial microcompartments (BMCs) are selectively permeable proteinaceous organelles which encapsulate segments of metabolic pathways across bacterial phyla. They consis …

Nat Struct Mol Biol JAN. 1, 2008

Structural basis of enzyme encapsulation into a bacterial nanocompartment

M Sutter et al

Compartmentalization is an important organizational feature of life. It occurs at varying levels of complexity ranging from eukaryotic organelles and the bacterial microc …

Science AUG. 5, 2005

Protein structures forming the shell of primitive bacterial organelles

CA Kerfeld et al

Bacterial microcompartments are primitive organelles composed entirely of protein subunits. Genomic sequence databases reveal the widespread occurrence of microcompartmen …

Arch Microbiol JAN. 1, 2000

Identification and localization of the carboxysome peptide Csos3 and its corresponding gene in Thiobacillus neapolitanus

SH Baker et al

Four genes encoding carboxysome shell peptides (csoS1A, csoS1B, csoS1C, csoS2), the genes encoding the large and small subunits of RuBisCO (cbbL, cbbS), and three unident …

Protein Sci JAN. 4, 2013

Using comparative genomics to uncover new kinds of protein-based metabolic organelles in bacteria

J Jorda et al

Bacterial microcompartment (MCP) organelles are cytosolic, polyhedral structures consisting of a thin protein shell and a series of encapsulated, sequentially acting enzy …

PLoS Comput Biol OCT. 23, 2014

A taxonomy of bacterial microcompartment loci constructed by a novel scoring method

SD Axen et al

Bacterial microcompartments (BMCs) are proteinaceous organelles involved in both autotrophic and heterotrophic metabolism. All BMCs share homologous shell proteins but di …

PLoS Comput Biol MAY 5, 2017

A systems-level model reveals that 1,2-Propanediol utilization microcompartments enhance pathway flux through intermediate sequestration

CM Jakobson et al

The spatial organization of metabolism is common to all domains of life. Enteric and other bacteria use subcellular organelles known as bacterial microcompartments to spa …

Elife APRIL 29, 2014

Systems analysis of the CO2 concentrating mechanism in cyanobacteria

N Mangan et al

Cyanobacteria are photosynthetic bacteria with a unique CO2 concentrating mechanism (CCM), enhancing carbon fixation. Understanding the CCM requires a systems level persp …

Proc Natl Acad Sci U S A MARCH 22, 2010

Short N-terminal sequences package proteins into bacterial microcompartments

C Fan et al

Hundreds of bacterial species produce proteinaceous microcompartments (MCPs) that act as simple organelles by confining the enzymes of metabolic pathways that have toxic …

Cell NOV. 21, 2013

Biogenesis of a bacterial organelle: the carboxysome assembly pathway

JC Cameron et al

The carboxysome is a protein-based organelle for carbon fixation in cyanobacteria, keystone organisms in the global carbon cycle. It is composed of thousands of subunits …

Proc Natl Acad Sci U S A FEB. 23, 2015

Selective molecular transport through the protein shell of a bacterial microcompartment organelle

C Chowdhury et al

Bacterial microcompartments are widespread prokaryotic organelles that have important and diverse roles ranging from carbon fixation to enteric pathogenesis. Current mode …

Biol Direct NOV. 13, 2017

Cellular origin of the viral capsid-like bacterial microcompartments

M Krupovic et al

This article was reviewed by Igor Zhulin, Jeremy Selengut and Narayanaswamy Srinivasan. For complete reviews, see the Reviewers' reports section.

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