Leonardo Mariño-Ramírez, PhD

Staff Scientist, Computational Biology Branch
Bioinformatics of Chromatin Structure Group
NCBI, NLM, NIH

Research Interests

  • In silico identification of gene regulatory elements in eukaryotes.
  • Molecular and cellular interactions controlling gene expression in eukaryotes.
  • Evolution of eukaryotic gene regulatory elements.
  • Database design for biological data.

Selected Publications

  • Draizen, E. J., Shaytan, A. K., Mariño-Ramírez, L., Talbert, P. B., Landsman, D., Panchenko, A. R. (2016) HistoneDB 2.0: a histone database with variants—an integrated resource to explore histones and their variants. Database (Oxford):baw014. [PubMed] [PDF]
  • Deng, T., Zhu, Z. I., Zhang, S., Leng, F., Cherukuri, S., Hansen, L., Mariño-Ramírez, L., Meshorer, E., Landsman, D. and Bustin, M. (2013) HMGN1 Modulates Nucleosome Occupancy and DNase I Hypersensitivity at the CpG Island Promoters of Embryonic Stem Cells. Mol Cell Biol. 33:3377-3389. [PubMed] [PDF]
  • Garzón-Martínez, G. A., Zhu, I., Landsman, D., Barrero, L. S. and Mariño-Ramírez, L. (2012) The Physalis peruviana leaf transcriptome: assembly, annotation and gene model prediction. BMC Genomics. 13:151. [PubMed] [PDF] http://www.biomedcentral.com/1471-2164/13/151
  • Mariño-Ramírez, L., Levine, K. M., Morales, M., Zhang, S., Moreland, R. T., Baxevanis, A. D. and Landsman D. (2011) The Histone Database: an integrated resource for histones and histone fold-containing proteins. Database (Oxford):bar048. [PubMed] [PDF]
  • Hansen, L., Mariño-Ramírez, L. and Landsman, D. (2010) Many sequence-specific chromatin modifying protein-binding motifs show strong positional preferences for potential regulatory regions in the Saccharomyces cerevisiae genome. Nucleic Acids Research. 38:1772-1779. [PubMed] [PDF]
  • Huda, A., Mariño-Ramírez, L., Landsman, D. and Jordan, I. K. (2009) Repetitive DNA elements, nucleosome binding and human gene expression. Gene. 436:12-22. [PubMed] [PDF]
  • Tharakaraman, K., Bodenreider, O., Landsman, D., Spouge, J. L. and Mariño-Ramírez, L. (2008) The biological function of some human transcription factor binding motifs varies with position relative to the transcription start site. Nucleic Acids Research. 36:2777-2786. [PubMed] [PDF]
  • Piriyapongsa, J., Mariño-Ramírez, L. and Jordan, I. K. (2007) Origin and evolution of human microRNAs from transposable elements. Genetics. 176:1323-1337. [PubMed] [PDF] http://www.f1000biology.com/article/17435244
  • Mariño-Ramírez, L., Jordan, I. K. and Landsman, D. (2006) Multiple independent evolutionary solutions to core histone gene regulation. Genome Biology. 7:R122. [PubMed] [PDF] http://genomebiology.com/2006/7/12/R122
  • Mariño-Ramírez, L., Kann, M. G., Shoemaker, B. A. and Landsman, D. (2005) Histone structure and nucleosome stability. Expert Review of Proteomics. 2:719-729. [PubMed] [PDF]
  • Mariño-Ramírez, L., Spouge, J. L., Kanga, G. C. and Landsman, D. (2004) Statistical analysis of over-represented words in human promoter sequences. Nucleic Acids Research. 32:949-958. [PubMed] [PDF]

Publications in PubMed

Leonardo Mariño-Ramírez

Contact Information
Building 38A, Room 6S614-M
8600 Rockville Pike MSC 6075
Bethesda, MD 20894-6075

Tel: +1-301-402-3708
Fax: +1-301-480-2288
marino@ncbi.nlm.nih.gov

Last updated: 2016-07-25T16:05:14-04:00