MutaBind evaluates the effects of variations and disease mutations on protein-protein interactions only for soluble complexes. It predicts if a mutation disrupts an interaction and calculates the change in binding affinity. The structure of a protein-protein complex is required for this method.



Step 1 - Select Protein Complex


Example: 1CSE
Bioassembly
Asymmetric Unit


Reference

Li M, Simonetti FL, Goncearenco A & Panchenko AR. MutaBind estimates and interprets the effects of sequence variants on protein-protein interactions. Nucleic Acids Res. (2016 Web Server Issue). PMID: 27150810


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