MutaBind evaluates the effects of variations and disease mutations on protein-protein interactions only for soluble complexes. It predicts if a mutation disrupts an interaction and calculates the change in binding affinity. The structure of a protein-protein complex is required for this method.
Li M, Simonetti FL, Goncearenco A & Panchenko AR. MutaBind estimates and interprets the effects of sequence variants on protein-protein interactions. Nucleic Acids Res. (2016 Web Server Issue). PMID: 27150810