V - Defense mechanisms

Download

Stats

COG definitions	Organims	Proteins	Median Protein Length	Genes
198	2,290	229,234	318.0	175

Organism	Protein	COG	Cat	Annotation
2016	6321	COG0251	V	Enamine deaminase RidA/Endoribonuclease Rid7C, YjgF/YER057c/UK114 family
1625	3935	COG0286	V	Type I restriction-modification system, DNA methylase subunit
1209	3103	COG0312	V O	Zn-dependent protease or N-deacetylase, PmbA/TldD/TldE family
1133	1522	COG0386	V I	Thioredoxin/glutathione peroxidase BtuE, reduces lipid peroxides
2044	6364	COG0388	V	Nitrilase/amidase YafV/Nit2, hydrolyzes deaminated glutathione
1667	2531	COG0450	V	Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin)
2046	6136	COG0494	V	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family
1865	6482	COG0534	V	Na+-driven multidrug efflux pump, DinF/NorM/MATE family
1673	6431	COG0577	V	ABC-type antimicrobial peptide transport system, permease component
1072	1676	COG0610	V	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases ...
994	1433	COG0627	V	S-formylglutathione hydrolase FrmB
1641	3279	COG0693	V	Protein/nucleotide deglycase, PfpI/YajL/DJ-1 family (repair of methylglyoxal-glycated proteins and nucleic acids)
1047	1542	COG0701	V P	Arsenite and antimonite resistance protein ArsP/YraQ, UPF0718 family
1292	2487	COG0732	V	Restriction endonuclease S subunit
1386	2716	COG0737	V F	2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family
1664	1720	COG0756	V F	dUTP pyrophosphatase (dUTPase)
1659	8659	COG0841	V	Multidrug efflux pump subunit AcrB
1992	7359	COG0842	V	ABC-type multidrug transport system, permease component
1769	12148	COG0845	V M	Multidrug efflux pump subunit AcrA (membrane-fusion protein)
1341	2344	COG0861	V P	Tellurite resistance membrane protein TerC
1160	2479	COG0863	L V	DNA modification adenine methylase
570	840	COG1002	V	Type II restriction/modification system, endonuclease and methylase domains
84	85	COG1059	L V	Thermostable 8-oxoguanine DNA glycosylase
2184	16989	COG1131	J V	Ribosome-associated ATPase or ATPase component of an ABC-type multidrug transport system
2159	13047	COG1132	V M	ABC-type multidrug and LPS transport system, ATPase and permease component MsbA
121	121	COG1133	V	Peptide antibiotic transporter SbmA/BacA, ABC-type permease family
764	1001	COG1203	V	CRISPR-Cas type I system-associated endonuclease/helicase Cas3
940	1187	COG1238	V P	Membrane protein YqaA involved in indium extrusion, DedA family, contains VTT domain
533	620	COG1275	V	Tellurite resistance protein TehA and related permeases
117	123	COG1332	V	CRISPR-Cas system type III CSM-effector complex subunit Csm5, RAMP superfamily Cas7 group
196	250	COG1336	V	CRISPR-Cas system type III CMR-effector complex subunit Cmr4, RAMP superfamily Cas7 group
238	566	COG1337	V	CRISPR-Cas system type III CSM-effector complex subunit Csm3, RAMP superfamily Cas7 group
690	1022	COG1343	V	CRISPR/Cas system-associated endoribonuclease Cas2
337	471	COG1353	V	CRISPR/Cas system-associated protein Cas10, large subunit of type III CRISPR-Cas systems, contains HD superfamily nuclease domain
153	173	COG1367	V	CRISPR-Cas system type III CMR-effector complex subunit Cmr1, RAMP superfamily Cas7 group
475	566	COG1401	V	5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB
1269	2519	COG1403	V	HNH family endonuclease, includes 5-methylcytosine-specific restriction endonuclease McrA
110	114	COG1421	V	CRISPR-Cas system type III CSM-effector complex small subunit Csm2
168	190	COG1431	J V	PIWI domain, catalyzes dsRNA-guided hydrolysis of ssRNA, involved in RNA silencing, RNA metabolism and antiviral defense
696	981	COG1468	V	CRISPR/Cas system-associated exonuclease Cas4, RecB family
815	1236	COG1479	V	DNAse/DNA nickase specific for phosphorothioated or glycosylated phage DNA, GmrSD/DndB/SspE family, contains DUF262 and HNH nuclease domains
865	2595	COG1487	V	Ribonuclease/mRNA interferase VapC, contains PIN domain
42	65	COG1517	V	CRISPR/Cas system-associated protein Csx1, contains CARF domain
1010	1543	COG1518	V	CRISPR-Cas system-associated integrase Cas1
1523	7957	COG1566	V	Multidrug resistance efflux pump EmrA
123	127	COG1567	V	CRISPR-Cas system type III CSM-effector complex subunit Csm4, RAMP superfamily Cas5 group
248	276	COG1578	V	House-cleaning carbohydrate phosphatase, DUF89 family
274	371	COG1583	V	CRISPR/Cas system endoribonuclease Cas6, RAMP superfamily
666	1916	COG1598	V	Antitoxin component HicB of the HicAB toxin-antitoxin system
182	218	COG1604	V	CRISPR/Cas system CMR subunit Cmr6, Cas7 group, RAMP superfamily
210	213	COG1659	V	Bacteriocin, linocin/CFP29 family
1534	7522	COG1680	V	CubicO group peptidase, beta-lactamase class C family
464	555	COG1688	V	CRISPR/Cas system-associated protein Cas5, RAMP superfamily
992	1296	COG1694	V	NTP pyrophosphatase, house-cleaning of non-canonical NTPs
146	153	COG1700	V	Predicted anti-virus defense system component AQ645, contains DUF2357 and PD-(D/E)xK nuclease domains
628	822	COG1715	V	Restriction endonuclease Mrr
64	105	COG1753	V	Predicted antitoxin, CopG family
1053	1921	COG1764	V	Organic hydroperoxide reductase OsmC/OhrA
147	171	COG1769	V	CRISPR-Cas system type III CMR-effector complex subunit Cmr3, RAMP superfamily Cas5 group
299	357	COG1787	V	Endonuclease, HJR/Mrr/RecB family
926	1297	COG1842	V M	Phage shock protein A involved in membrane remodeling, PspA/Vipp1/IM30 family
591	1383	COG1848	V	VapC family ribonuclease, toxin component of the VapBC toxin-antitoxin module, contains PIN domain
173	198	COG1857	V	CRISPR-Cas system type I effector complex subunit Cas7, RAMP superfamily
224	318	COG1895	V	HEPN domain protein, predicted toxin of MNT-HEPN system
670	725	COG1912	V H	Stereoselective (R,S)-S-adenosylmethionine hydrolase (adenosine-forming)
931	1084	COG1956	V T	GAF domain-containing protein, putative methionine-R-sulfoxide reductase
308	318	COG1986	V F	Non-canonical (house-cleaning) NTP pyrophosphatase, all-alpha NTP-PPase family
578	1018	COG2002	K B V	DNA-binding transcriptional regulator, chromatin protein or antitoxin AbrBPrlF/Sso7c4, AbrB family
684	1272	COG2026	V	mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system
1247	2413	COG2076	V	Multidrug transporter EmrE and related cation transporters
959	4871	COG2124	V Q	Cytochrome P450
605	1011	COG2161	V	Antitoxin component YafN of the YafNO toxin-antitoxin module, PHD/YefM family
258	669	COG2250	V	HEPN domain protein, predicted toxin of MNT-HEPN system
647	1031	COG2253	V	Predicted nucleotidyltransferase component of viral defense system
41	48	COG2254	V	CRISPR/Cas system-associated endonuclease Cas3-HD
1053	1432	COG2258	V F	N-hydroxylaminopurine reductase YiiM, contains MOSC domain
1163	2682	COG2274	V	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain
395	525	COG2336	V	Antitoxin component MazE of the MazEF toxin-antitoxin module
964	1866	COG2337	V	mRNA-degrading endonuclease MazF, toxin component of the MazEF toxin-antitoxin module
447	869	COG2361	V	HEPN domain protein, predicted toxin of MNT-HEPN system
904	1646	COG2367	V	Beta-lactamase class A
240	540	COG2402	V	Ribonuclease VapC1, toxin component of the VapBC toxin-antitoxin module, contains PIN domain
333	1199	COG2442	V	Predicted antitoxin component of a toxin-antitoxin system, DUF433 family
265	287	COG2602	V	Beta-lactamase class D
474	709	COG2720	V	Vancomycin resistance protein YoaR (function unknown), contains peptidoglycan-binding and VanW domains
250	285	COG2746	V	Aminoglycoside N3'-acetyltransferase
215	272	COG2810	V	Predicted type IV restriction endonuclease
390	1134	COG2849	V	Antitoxin component YwqK of the YwqJK toxin-antitoxin module
478	538	COG2914	V	Putative antitoxin component PasI (RatB) of the RatAB toxin-antitoxin module, ubiquitin-RnfH superfamily
364	754	COG2929	V	Ribonuclease BrnT, toxin component of the BrnT-BrnA toxin-antitoxin system
224	266	COG3015	V M	Uncharacterized lipoprotein NlpE involved in copper resistance
315	452	COG3041	J V	mRNA-degrading endonuclease YafQ (mRNA interferase), toxin component of the YafQ-DinJ toxin-antitoxin module
131	166	COG3059	V	Reactive chlorine resistance protein RclC/YkgB, DUF417 family
362	614	COG3077	V	Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module
765	1295	COG3093	V	Plasmid maintenance system antidote protein VapI/HigA, contains XRE-type HTH domain
213	214	COG3155	V	Glyoxalase ElbB, DJ-1 superfamily
303	336	COG3183	V	5-methylcytosine-specific restriction endonuclease McrA
735	837	COG3217	V F	N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain
295	360	COG3236	V H	N-glycosidase YbiA/RibX (riboflavin biosynthesis, damage control), NADAR superfamily
47	55	COG3309	V	Virulence-associated protein VapD, endoribonuclease
109	120	COG3337	V	CRISPR-Cas system type III CMR-effector complex small subunit Cmr5
782	3365	COG3415	V	CRISPR-associated protein Csa3, CARF domain
93	99	COG3421	V	Type III restriction endonuclease
552	710	COG3440	V	Predicted restriction endonuclease
854	1719	COG3467	V	Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5'-phosphate oxidase superfamily
141	161	COG3510	V M	Rhamnose/hydroxycephalosporin O-methyltransferase, CmcI/Rv2959c family
196	203	COG3512	V	CRISPR/Cas system-associated protein Cas2
233	251	COG3513	V	CRISPR-Cas system type-II protein Cas9
308	552	COG3514	V	Antitoxin component of the BrnT-BrnA toxin-antitoxin system
486	710	COG3549	V	Plasmid maintenance system killer protein
215	274	COG3570	V	Streptomycin 6-kinase
92	115	COG3582	V	CDC48-associated ubiquitin-like protein CUZ1, contains AN1-type Zn-finger (protection from As/Sb toxicity)
297	347	COG3587	V	Restriction endonuclease, type III RM system
647	704	COG3634	V	Alkyl hydroperoxide reductase subunit AhpF
376	416	COG3649	V	CRISPR-Cas system type I effector complex subunit Cas7, RAMP superfamily
278	389	COG3657	V	Putative component of the toxin-antitoxin plasmid stabilization module
174	174	COG3725	V	Membrane protein AmpE required for beta-lactamase induction
136	210	COG3742	V	VapC family ribonuclease, toxin component of the VapBC toxin-antitoxin module, contains PIN domain
368	739	COG3744	V	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain)
105	107	COG3811	V	Toxin component YjhX of the YjhX-YjhQ toxin-antitoxin system, inhibitor of topoisomerase I, UPF0386/DUF2084 family
438	495	COG3853	V	Uncharacterized conserved protein YaaN involved in tellurite resistance
117	143	COG3896	V	Chloramphenicol 3-O-phosphotransferase
101	119	COG4006	V	CRISPR-Cas system-associated protein Csm6, contains CARF domain
579	781	COG4096	V	Type I site-specific restriction endonuclease, part of a restriction-modification system
103	125	COG4110	V	Tellurium resistance protein TerA/TerD
376	720	COG4113	A V	RNA interferase (RNase) VapC, contains PIN domain
472	684	COG4115	V	Toxin component of the Txe-Axe toxin-antitoxin module, Txe/YoeB family
560	1254	COG4118	V	Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor, Phd/VapB family
130	131	COG4167	V	ABC-type antimicrobial peptide export system, ATPase component SapF
122	122	COG4168	V	ABC-type antimicrobial peptide export system, permease component SapB
130	130	COG4170	V	ABC-type antimicrobial peptide export system, ATPase component SapD
142	142	COG4171	V	ABC-type antimicrobial peptide export system, permease component SapC
235	487	COG4200	V	Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family
612	1207	COG4257	V	Streptogramin lyase
341	380	COG4268	V	5-methylcytosine-specific restriction endonuclease McrBC, regulatory subunit McrC
38	46	COG4343	V	CRISPR/Cas system-associated exonuclease Cas4, RecB family
85	110	COG4374	V	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain)
236	427	COG4403	V	Lantibiotic modifying enzyme
124	175	COG4423	V	VapB family antitoxin component of VapBC type II toxin-antitoxin module
239	246	COG4452	V	Inner membrane protein CreD involved in colicin E2 resistance
200	262	COG4461	V	Lysozyme inhibitor LprI
430	615	COG4679	V X	Phage-related protein gp49, toxin component of the Tad-Ata toxin-antitoxin system
274	387	COG4680	J V	mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module
145	193	COG4683	V	HigB/gp49-like toxin component of RelE/ParE type II toxin-antitoxin system
241	303	COG4691	V	Plasmid stability protein StbC1, contains ribbon-helix-helix domain
118	155	COG4734	V	Antirestriction protein ArdA
409	718	COG4767	V	Glycopeptide antibiotics resistance protein
286	382	COG4823	V	Abortive infection bacteriophage resistance protein
283	298	COG4832	V T	Cyclopropanoid cyclopropyl hydrolase, GyrI-like domain
286	813	COG4842	V	Secreted virulence factor YukE/EsxA, WXG100 family
229	269	COG4845	V	Chloramphenicol O-acetyltransferase
167	179	COG4924	V	Nuclease subunit JetD of Wadjet anti-plasmid defense system, contains DUF3322 and JetD_C (DUF2220) domains
155	172	COG4951	V	CRISPR-associated primase-polymerase type A
634	1103	COG5340	V	Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system
153	254	COG5428	V	Predicted antitoxin component YuzE of a toxin-antitoxin system, DUF2283 family
238	264	COG5441	V	ATP-binding helicase-inhibiting domain, Tm-1/UPF0261 family
39	124	COG5444	V	Predicted ribonuclease, toxin component of the YeeF-YezG toxin-antitoxin module
343	525	COG5499	V	Antitoxin component HigA of the HigAB toxin-antitoxin module, contains an N-terminal HTH domain
130	129	COG5503	K V	DNA-dependent RNA polymerase auxiliary subunit epsilon
317	412	COG5510	V	Entericidin EcnA/EcnB
268	372	COG5551	V	CRISPR/Cas system endoribonuclease Cas6, RAMP superfamily
237	342	COG5606	V	Antitoxin component of the Tad-Ata toxin-antitoxin system, contains XRE-type HTH domain
325	387	COG5608	V	Dessication stress tolerance protein, LEA/WHy domain
377	567	COG5642	V	Predicted antitoxin component of a toxin-antitoxin system, contains Xre-type HTH domain
295	421	COG5654	V	Predicted toxin component of a toxin-antitoxin system, contains RES domain
337	389	COG5658	V	Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family
68	81	COG5930	V	CRISPR-Cas system type I-D effector complex large subunit Cas10d/Csc3, contains HD superfamily nuclease domain
13	14	COG5931	V	CRISPR-Cas system type-V protein Cas12a
90	100	COG5932	V	CRISPR-Cas type I-F system-associated endonuclease/helicase Cas3f, fused to Cas2 domain
92	96	COG5933	V	CRISPR-Cas system type I-F effector complex subunit Cas5f/Csy2, RAMP superfamily
235	259	COG5934	V	CRISPR-Cas system endoribonuclease Cas6e, RAMP superfamily
96	104	COG5935	V	CRISPR-Cas system endoribonuclease Cas6f/Csy4, RAMP superfamily
92	98	COG5936	V	CRISPR-Cas system type I-F effector complex subunit Cas7f/Csy3, RAMP superfamily
14	14	COG5937	V	CRISPR-Cas system type I-A effector complex large subunit Cas8a4
119	129	COG5938	V	CRISPR-Cas system type I-B effector complex large subunit Cas8b1
84	91	COG5939	V	CRISPR-Cas system type I-B effector complex large subunit Cas8b2
19	19	COG5940	V	CRISPR-Cas system type I-B effector complex large subunit Cas8b3
234	246	COG5941	V	CRISPR-Cas system type I-C effector complex large subunit Cas8c
225	246	COG5942	V	CRISPR-Cas system type I-E effector complex large subunit Cas8e/Cse1
89	92	COG5943	V	CRISPR-Cas system type I-F effector complex large subunit Cas8f/Csy1
43	50	COG5944	V	CRISPR-Cas system type I-G effector complex large subunit Cas8g1
59	68	COG5945	V	CRISPR-Cas system type I-G effector complex subunit Csb1/Cas7u, RAMP superfamily Cas7 group
59	71	COG5946	V	CRISPR-Cas system type I-G effector complex subunit Csb5, RAMP superfamily Cas5 group
69	76	COG5947	V	CRISPR-Cas system type I-D effector complex subunit Csc1, RAMP superfamily Cas5 group
78	86	COG5948	V	CRISPR-Cas system type I-D effector complex subunit Csc2, RAMP superfamily Cas7 group
225	245	COG5949	V	CRISPR-Cas system type I-E effector complex small subunit Cse2
140	162	COG5950	V	CRISPR-Cas system type II-D effector complex subunit Csx10, RAMP superfamily Cas5 group
9	13	COG5951	V X	Anti-CRISPR type II-A1 protein, inhibits CRISPR-Cas type II-A system
2	2	COG5952	V X	Anti-CRISPR type II-A2 protein, inhibits CRISPR-Cas type II-A system
14	14	COG5953	V X	Anti-CRISPR type II-A6 protein, inhibits CRISPR-Cas type II-A system
4	4	COG5954	V X	Anti-CRISPR type II-C2 protein, inhibits CRISPR-Cas type II-A system
13	13	COG5955	V X	Anti-CRISPR type II-C1 protein, inhibits CRISPR-Cas type II-A system
1	1	COG5956	V X	Anti-CRISPR type V-A1 protein, inhibits CRISPR-Cas12a nuclease
17	23	COG5957	V	Cas10-like subunit of HRAMP, derivative of type III CRISPR-Cas system
213	229	COG5959	V	PglZ domain-containing phosphodiesterase/nuclease in Type 1,2,5 and 6 BREX phage resistance systems, AlkP superfamily
49	49	COG5960	V	PglZ domain-containing component of Type 3 BREX phage resistance system, AlkP superfamily
12	12	COG5966	V	PglZ domain-containing component of Type 4 BREX phage resistance system, AlkP superfamily
20	20	COG5967	V	PglZ domain-containing component of Type 1B BREX phage resistance system, AlkP superfamily