T - Signal transduction mechanisms

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COG definitions	Organims	Proteins	Median Protein Length	Genes
254	2,290	442,379	344.0	236

Organism	Protein	COG	Cat	Annotation
1667	2492	COG0248	T F	Exopolyphosphatase/pppGpp-phosphohydrolase
869	1153	COG0271	K T	DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation
1992	3179	COG0317	K T	(p)ppGpp synthase/hydrolase, HD superfamily
1589	3122	COG0347	T E	Nitrogen regulatory protein PII
1924	4037	COG0394	T	Protein-tyrosine-phosphatase
1276	2789	COG0464	D T M	AAA+-type ATPase, SpoVK/Ycf46/Vps4 family
547	1491	COG0467	T	RecA-superfamily ATPase, KaiC/GvpD/RAD55 family
247	254	COG0478	T	RIO-like serine/threonine protein kinase fused to N-terminal HTH domain
499	592	COG0490	T P	K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain
1575	14148	COG0515	T	Serine/threonine protein kinase, uncludes type III secretion system effector YopO
1692	3075	COG0517	T	CBS domain
1963	5583	COG0569	T P	Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain
1846	10416	COG0589	T	Nucleotide-binding universal stress protein, UspA family
1281	1938	COG0618	A T	nanoRNase/pAp phosphatase, hydrolyzes c-di-AMP and oligoRNAs
1382	2909	COG0631	T	Serine/threonine protein phosphatase PrpC
569	581	COG0639	T	Diadenosine tetraphosphatase ApaH/serine/threonine protein phosphatase, PP2A family
2071	22658	COG0642	T	Signal transduction histidine kinase
1247	2843	COG0643	T	Chemotaxis protein histidine kinase CheA
1608	2609	COG0661	T H	Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family
1885	11746	COG0664	T	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases
1208	3924	COG0666	T	Ankyrin repeat
2122	31346	COG0745	K T	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain
1646	18168	COG0784	T	CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F
1776	11730	COG0834	T E	ABC-type amino acid transport/signal transduction system, periplasmic component/domain
1242	4189	COG0835	T	Chemotaxis signal transduction protein CheW
1358	16731	COG0840	T	Methyl-accepting chemotaxis protein (MCP)
779	1143	COG1073	T	Fermentation-respiration switch esterase FrsA, DUF1100 family
1934	1939	COG1217	T	Predicted membrane GTPase TypA/BipA involved in stress response
105	113	COG1221	K T	Transcriptional regulators containing sigma54-interacting ATPase domain
1965	4461	COG1253	T P	Mg2+ efflux pump MpfA, contains CBS pair and CorC-HlyC domains, TlyC/UPF0053 family
1301	2871	COG1352	T	Methylase of chemotaxis methyl-accepting proteins
821	2886	COG1366	T	Anti-anti-sigma factor (antagonist of anti-sigma factor), STAS domain
1587	4116	COG1409	T	3',5'-cyclic AMP phosphodiesterase CpdA
405	458	COG1437	T R	Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function)
608	620	COG1480	T	Cyclic di-AMP-specific phosphodiesterase PgpH, HD superfamily
770	784	COG1489	T G	DNA-binding protein, stimulates sugar fermentation
1059	1307	COG1493	T	Serine kinase of the HPr protein, regulates carbohydrate metabolism
1097	1871	COG1524	T	c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily
709	1034	COG1551	T	sRNA-binding carbon storage regulator CsrA
297	297	COG1623	T	c-di-AMP synthetase DisA, contains DAC, linker, and DNA-binding domains
59	61	COG1624	T	c-di-AMP synthetase, contains the diadenylate cyclase (DAC) domain
498	2142	COG1639	T	HD-like signal output (HDOD) domain, no enzymatic activity
820	833	COG1642	T	c-di-AMP synthetase CdaA, contains 3TM and DAC domains
1415	1427	COG1660	T	RNase adaptor protein RapZ for GlmZ sRNA degradation, contains a P-loop ATPase domain
926	925	COG1666	T	Cyclic di-GMP-binding protein YajQ, UPF0234 family
728	744	COG1692	T	2',3'- and 3',5'-cNMP phosphodiesterase YmdB, calcineurin family
1843	1955	COG1702	T	Phosphate starvation-inducible protein PhoH, predicted ATPase
504	531	COG1713	T R	Diadenosine tetraphosphatase YqeK or a related HD superfamily phosphohydrolase
1012	5031	COG1716	T	Forkhead associated (FHA) domain, binds pSer, pThr, pTyr
411	443	COG1718	T	Serine/threonine-protein kinase RIO1
1062	2130	COG1744	T	Lipoprotein Med, regulator of KinD/Spo0A, PBP1-ABC superfamily, includes NupN
102	111	COG1751	T G	Ligand-binding PK_C domain of pyruvate kinase and diadenylate cyclases
1292	3162	COG1762	T G	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)
772	805	COG1774	T	Cell fate regulator YaaT, PSP1 superfamily (controls sporulation, competence, biofilm development)
566	967	COG1776	T	Phosphoaspartate phosphatase CheC, specific for CheY-P
905	965	COG1806	T	Regulator of PEP synthase PpsR, kinase-PPPase family (combines ADP:protein kinase and phosphorylase activities)
470	482	COG1854	T	S-ribosylhomocysteine lyase LuxS, autoinducer biosynthesis
752	931	COG1871	T	Chemotaxis receptor (MCP) glutamine deamidase CheD
1002	1065	COG1923	T	sRNA-binding regulator protein Hfq
1544	2700	COG1925	T G	HPr or related phosphotransfer protein
931	1084	COG1956	V T	GAF domain-containing protein, putative methionine-R-sulfoxide reductase
1755	2770	COG1974	K T	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)
911	1406	COG1983	K T	Phage shock protein PspC (stress-responsive transcriptional regulator)
378	429	COG1993	T	PII-like signaling protein
338	998	COG2018	T	Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family
1367	1741	COG2062	T	Phosphohistidine phosphatase SixA
180	194	COG2112	T	Predicted Ser/Thr protein kinase
1053	4203	COG2114	T	Adenylate cyclase, class 3
1063	3320	COG2172	T	Anti-sigma regulatory factor (Ser/Thr protein kinase)
367	447	COG2184	T	Fido, protein-threonine AMPylation domain
1861	17952	COG2197	K T	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains
1021	3056	COG2198	T	HPt (histidine-containing phosphotransfer) domain
1453	17089	COG2199	T	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants
1289	7129	COG2200	T	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)
1280	2822	COG2201	T	Chemotaxis response regulator CheB, contains REC and protein-glutamate methylesterase domains
1371	5506	COG2202	T	PAS domain
1531	9153	COG2203	T	GAF domain
1674	15232	COG2204	T	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains
1717	6132	COG2205	T	K+-sensing histidine kinase KdpD
990	3911	COG2206	T	HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant)
1030	3773	COG2208	K T	Phosphoserine phosphatase RsbU, regulator of sigma subunit
202	882	COG2310	T	Stress response protein SCP2
1224	2188	COG2334	T	Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist
555	730	COG2339	T	Membrane proteinase PrsW, cleaves anti-sigma factor RsiW, M82 family
547	766	COG2357	T F	ppGpp synthetase catalytic domain (RelA/SpoT-type nucleotidyltranferase)
624	911	COG2365	T	Protein tyrosine/serine phosphatase Oca4
258	290	COG2404	J T	Oligoribonuclease NrnA/c-di-AMP phosphodiesterase DhhP, DHH superfamily
588	742	COG2453	T	Protein-tyrosine phosphatase
59	119	COG2469	T	Archaeal chemotaxis protein CheF
479	1177	COG2703	T	Hemerythrin
21	21	COG2724	T	c-di-AMP synthetase CdaS, contains YojJ and DAC domains
141	145	COG2725	T	c-di-AMP synthetase, DacZ/CdaZ superfamily, contains PK_C-type and DAC domains
574	679	COG2766	T	Predicted Ser/Thr protein kinase
967	2024	COG2770	T	HAMP domain
591	656	COG2808	T	Predicted FMN-binding regulatory protein PaiB
1005	1038	COG2844	T O	UTP:GlnB (protein PII) uridylyltransferase
1669	4021	COG2905	T	Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains
498	526	COG2912	T	Regulator of sirC expression, contains transglutaminase-like and TPR domains
294	294	COG2915	T X	Regulator of phage lambda lysogenization HflD, binds to CII and stimulates its degradation
595	596	COG2921	T	Putative lipoate-binding regulatory protein, UPF0250 family
512	1545	COG2972	T	Sensor histidine kinase YesM
689	738	COG2976	T	Ancillary subunit YfgM of SecYEG translocon, regulates RcsB-dependent stress response
399	403	COG3026	T	RseB, negative regulator of sigma E activity
362	363	COG3045	T	Periplasmic catabolite regulation protein CreA (function unknown)
179	184	COG3072	T	Adenylate cyclase, class I
407	411	COG3073	T	RseA, negative regulator of sigma E activity
208	239	COG3083	T M	Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily
482	531	COG3086	T	RseC, positive regulator of sigma E activity
326	328	COG3106	T	Ras-like GTP-binding stress-induced protein YcjX, DUF463 family
279	310	COG3109	T	sRNA-binding protein ProQ
106	129	COG3110	T W	Curli synthesis inhibitor CsgI, YccT/UPF0319 family
439	572	COG3143	T N	Phosphoaspartate phosphatase CheZ, dephosphorylates CheY~P
707	1111	COG3193	T	Formaldehyde-binding sensor protein EfgA, GlcG/HbpS family
409	533	COG3213	T	Nitric oxide response protein NnrS
306	369	COG3215	T N W	Type IV pilus assembly protein/c-di-GMP receptor domain PilZ
471	543	COG3228	T	Mlc titration factor MtfA, regulates ptsG expression
889	2993	COG3275	T	Sensor histidine kinase, LytS/YehU family
1073	4040	COG3279	K T	DNA-binding response regulator, LytR/AlgR family
463	645	COG3287	T	NO-sensing heme protein NosP, contains FIST domain
606	1304	COG3290	T	Sensor histidine kinase DipB regulating citrate/malate metabolism
496	2290	COG3292	T	Periplasmic ligand-binding sensor domain
381	536	COG3300	T	MHYT domain, NO-binding membrane sensor
274	379	COG3322	T	Iron-binding extracellular (periplasmic) sensor domain CHASE4
26	26	COG3400	T	Predicted c-di-AMP receptor, contains TrkA_N, RCK_C, and USP domains
352	372	COG3412	T	Phosphotransferase subunit DhaM of the dihydroxyacetone kinase DhaKLM complex, contains PTS-EIIA, HPr, and PEP-utilizing domains
325	328	COG3429	T G	Glucose-6-phosphate dehydrogenase activity regulator OpcA
383	700	COG3434	T	c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains
917	2454	COG3437	T	Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains
423	633	COG3447	T	Integral membrane sensor domain MASE1
1263	2370	COG3448	J T	CBS domain-containing protein, includes archaeal ribosome hibernation factor Dri
298	364	COG3452	T	Extracellular (periplasmic) sensor domain CHASE (specificity unknown)
693	815	COG3476	T	Tryptophan-rich sensory protein TspO/CrtK (mitochondrial benzodiazepine receptor homolog)
403	428	COG3480	T	Predicted secreted protein YlbL, contains PDZ domain
709	1499	COG3550	T	Serine/threonine protein kinase HipA, toxin component of the HipAB toxin-antitoxin module
178	182	COG3602	T	ACT domain, ACT-3 family
158	164	COG3603	T	ACT domain, ACT-7 family
797	1788	COG3604	K T	FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains
747	929	COG3605	T	Signal transduction protein containing GAF and PtsI domains
398	655	COG3614	T	Extracytoplasmic sensor domain CHASE1 (specificity unknown)
228	286	COG3641	T	Membrane regulatory protein PfoR, PTS_EIIC_2 domain (does not regulate perfringolysin expression)
330	473	COG3679	T	Cell fate regulator YlbF, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm development)
1244	5691	COG3706	K T	Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain
870	1501	COG3707	K T	Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains
518	2963	COG3712	T P	Periplasmic ferric-dicitrate binding protein FecR, regulates iron transport
429	598	COG3806	T	Anti-sigma factor ChrR, cupin superfamily
843	2941	COG3829	K T	RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains
573	588	COG3830	T	ACT domain, binds amino acids and other small ligands
496	907	COG3835	K T	Sugar diacid utilization regulator CdaR
426	442	COG3848	T	Phosphohistidine swiveling domain of PEP-utilizing enzymes
747	1340	COG3850	T	Signal transduction histidine kinase NarQ, nitrate/nitrite-specific
92	115	COG3851	T	Signal transduction histidine kinase UhpB, glucose-6-phosphate specific
716	756	COG3852	T	Signal transduction histidine kinase NtrB, nitrogen specific
275	327	COG3870	T	Cyclic di-AMP receptor DarA/PstA
317	323	COG3887	T	Cyclic di-AMP phosphodiesterase GdpP, contains GGDEF-like and DHH domains
195	227	COG3913	T U	Type VI secretion system regulator TagF/ImpM/SciT
238	323	COG3915	T	Pterin-binding regulatory protein
350	526	COG3916	T	N-acyl-homoserine lactone synthase LasI (autoinducer biosynthesis)
832	2527	COG3920	T	Two-component sensor histidine kinase, HisKA and HATPase domains
69	69	COG3925	T G	N-terminal domain of the PTS fructose-specific IIB component
395	485	COG3937	T Q	Phasin, polyhydroxyalkanoate synthesis regulator
185	255	COG3947	K T	Two-component response regulator, SAPR family, consists of REC, wHTH and BTAD domains
28	28	COG3984	T	Stand-alone REC domain, LytT-type
412	712	COG3989	T	Transcriptional regulator, contains DNA-binding LytTR domain
288	356	COG4179	T	c-di-GMP/c-di-AMP-binding protein ComFB
38	51	COG4180	T	c-di-GMP/c-di-AMP-binding protein ComFB, cyanobacterial family
838	2680	COG4191	T	Signal transduction histidine kinase regulating C4-dicarboxylate transport system
49	51	COG4192	T	Signal transduction histidine kinase regulating phosphoglycerate transport system
542	1302	COG4219	T	Signal transducer regulating beta-lactamase production, contains metallopeptidase domain
169	294	COG4250	T	DICT sensory domain found in diguanylate cyclases and two-component systems
741	2512	COG4251	T	Bacteriophytochrome (light-regulated signal transduction histidine kinase)
566	1307	COG4252	T	Extracytoplasmic sensor domain CHASE2 (specificity unknown)
973	2624	COG4319	T	SnoaL-fold ligand-binding domain
69	116	COG4371	T C	FLAP1 protein, involved in response to fluctuating light, FLAP1/DUF1517 family
226	231	COG4398	T	Small ligand-binding sensory domain FIST
447	515	COG4464	T	Tyrosine-protein phosphatase YwqE
120	215	COG4512	K T	Accessory gene regulator protein AgrB
121	123	COG4550	T	Cell fate regulator YmcA, YheA/YmcA/DUF963 family (controls sporulation, competence, biofilm development)
508	1196	COG4564	T	Signal transduction histidine kinase
538	843	COG4565	K T	DNA-binding response regulator DpiB of citrate/malate metabolism
553	1541	COG4566	K T	DNA-binding response regulator, FixJ family, consists of REC and HTH domains
498	566	COG4567	K T	DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains
253	258	COG4579	T	Isocitrate dehydrogenase kinase/phosphatase
1304	7956	COG4585	T	Signal transduction histidine kinase ComP
663	1000	COG4623	T M	Membrane-bound lytic murein transglycosylase MltF
128	133	COG4650	K T	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain
987	2848	COG4753	K T	Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains
227	263	COG4758	T	Membrane protein LiaF, inhibitor of the LiaRS two-component envelope stress sensory system
22	42	COG4831	T	Roadblock/LC7 domain
283	298	COG4832	V T	Cyclopropanoid cyclopropyl hydrolase, GyrI-like domain
92	101	COG4846	T	Regulator of biofilm dispersion, motility, and sporulation CcdC
198	205	COG4853	T	YycI protein, regulator of the WalKR two-component signal transduction system
684	696	COG4856	T	Cyclic di-AMP synthase regulator CdaR, YbbR domain
209	275	COG4862	K T N	Negative regulator MecA of genetic competence, sporulation and motility
190	191	COG4863	T	YycH protein, regulator of the WalKR two-component signal transduction system
241	407	COG4936	T	Ligand-binding sensor domain
123	188	COG4943	T	Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains
80	116	COG4945	T G	Carbohydrate-binding DOMON domain
569	931	COG4978	T	GyrI-like small molecule binding domain
85	85	COG4999	T	Uncharacterized domain of signal transduction histidine kinase BarA
1095	1752	COG5000	T	Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation
1063	6298	COG5001	T	Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain
1794	5160	COG5002	T	Sensor histidine kinase WalK
562	568	COG5007	T	Acid stress protein IbaG/YrbA, BolA-like family
204	235	COG5018	T	3'-5' exonuclease KapD, inhibitor of KinA-controlled sporulation
12	23	COG5019	T	TPR-controlled diguanylate cyclase, combines TPR and GGDEF domains
494	827	COG5126	T	Ca2+-binding protein, EF-hand superfamily
83	83	COG5212	T	cAMP phosphodiesterase
653	1247	COG5278	T	Extracytoplasmic sensor domain CHASE3 (specificity unknown)
661	870	COG5343	T	Anti-sigma-K factor RskA
255	256	COG5385	T	Histidine phosphotransfer protein ChpT, HPt domain
205	510	COG5388	T	PAS/LOV-type domain, PAS_5 family
504	515	COG5394	T Q	Polyhydroxyalkanoate synthesis regulator, binds DNA and PHA
34	43	COG5440	T	Global stress regulator YbjN, DUF2299 family
249	647	COG5457	A T	RNA-binding protein CcaF1 involved in sRNA maturation, turnover, C and P metabolism, and intracellular survival, YjiS/DUF1127 family
146	232	COG5524	T C	Bacteriorhodopsin
688	1338	COG5581	T N	Cyclic di-GMP-binding flagellar brake protein FlgZ/YcgR, contains PilZNR(YcgR) and PilZ domains
21	27	COG5599	T U	Type III secretion system effector, protein-tyrosine-phosphatase YopH
380	1003	COG5616	T	TolB amino-terminal domain (function unknown)
505	1319	COG5635	T	Predicted NTPase, NACHT family domain
169	209	COG5660	T	Anti-sigma-YlaC factor YlaD, contains Zn-finger domain
58	247	COG5750	T	Chlorophyll biosynthesis regulator GUN4/Ycf53 domain
70	72	COG5751	T	Photosynthetic regulator, contains GUN4/Ycf53 domain and N-terminal all-alpha domain
305	2035	COG5752	T	Signaling protein combining a Ser/Thr protein kinase domain and the GUN4/Ycf53 porphyrin-binding domain
73	74	COG5764	T C	Cyanobacterial/chloroplast FeS cluster protein Ycf34, regulator of photosynthetic electron transport, PF10718 domain
75	76	COG5768	T C	Cyanobacterial response regulator with REC-Ycf55 domain architecture
71	71	COG5780	T C	Acclimation of photosynthesis to environment protein APE1, affects chlorophyll fluorescence, DUF2854 (PF11016) domain
74	74	COG5788	T C	Cyanobacterial/chloroplast protein SipA, regulator of sensor kinase NblS (Hik33), DUF3148 (PF11347) family
266	325	COG5792	T C	Fusion of CP12 with N-terminal CBS domain pair
71	90	COG5793	T	Heterocyst patterning and differentiation ncRNA-binding protein PatR
252	330	COG5801	D T	Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains)
100	99	COG5802	D T	Stage 0 sporulation initiation phosphotransferase Spo0B
257	406	COG5803	D T	Stage 0 sporulation initiation response regulator Spo0F
152	437	COG5804	D T	Stage 0 sporulation regulatory phosphatase Spo0E
42	58	COG5805	D T	Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ)
47	114	COG5806	D T	Sporulation sensor histidine kinase B
20	20	COG5807	D T	Sporulation sensor histidine kinase C
30	37	COG5808	D T	Sporulation sensor histidine kinase D
1006	3435	COG5809	D T	Sporulation sensor histidine kinase E
83	83	COG5810	D T	Sporulation protein KbaA, activator of histidine kinase KinB
888	1775	COG5815	D T	Stage II sporulation protein SpoIIAA (anti-anti-sigma F factor), STAS domain
166	168	COG5848	D T	SigmaK-processing regulatory protein BofA (Bypass-of-forespore protein A)
118	118	COG5849	D T	SigmaK checkpoint regulator BofC (Bypass-of-forespore protein C)
91	90	COG5867	D T	Anti-sigma-F factor Fin
30	31	COG5927	T	Spo0B-type alpha-helical domain
1256	4122	COG5975	T	KinA-related sensor histidine kinase
185	220	COG5976	T	KinB-related sensor histidine kinase
949	2046	COG5977	T	KinC-related sensor histidine kinase
233	265	COG5978	T	KinD-related sensor histidine kinase
1787	23196	COG5979	T	KinE-related sensor histidine kinase
191	191	COG6076	T U	Response regulator PorX of type IX secretion system, combines REC with PglZ phosphodiesterase domain
58	198	COG6094	T	Halobacterial response regulator, contains REC and HalX domains
88	105	COG6095	K T	GlnL-type response regulators, contains REC and YcbB domains
15	20	COG6096	K T	Betaproteobacterial response regulator, contains REC and BetR domain
27	99	COG6097	T	HalOD1 domain (halobacterial output domain 1)