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O - Posttranslational modification, protein turnover, chaperones

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COG
definitions
Organims Proteins Median Protein
Length
Genes
214 2,296 304,538 281.0 190
Organism Protein COG Cat Annotation
681 724 COG0068 O Hydrogenase maturation factor HypF (carbamoyltransferase)
1878 4327 COG0071 O Small heat shock protein IbpA, HSP20 family
301 352 COG0170 M O Dolichol kinase
1919 2785 COG0225 O Peptide methionine sulfoxide reductase MsrA
1834 2400 COG0229 O Peptide methionine sulfoxide reductase MsrB
2065 2555 COG0234 O Co-chaperonin GroES (HSP10)
2152 7401 COG0265 O Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain
957 1021 COG0278 O Glutaredoxin-related protein
676 830 COG0298 O Hydrogenase maturation factor HybG, HypC/HupF family
825 997 COG0309 O Carbamoyl dehydratase HypE (hydrogenase maturation factor)
1209 3101 COG0312 V O Zn-dependent protease or N-deacetylase, PmbA/TldD/TldE family
1681 3409 COG0316 O Fe-S cluster assembly iron-binding protein IscA
1392 1627 COG0326 O Molecular chaperone, HSP90 family
2050 5367 COG0330 O Regulator of protease activity HflC, stomatin/prohibitin superfamily
1111 1415 COG0339 O Zn-dependent oligopeptidase, M3 family
1161 1170 COG0354 O Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters
713 822 COG0375 O Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion
1129 1547 COG0378 O Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase
1742 1811 COG0396 O Fe-S cluster assembly ATPase SufC
930 979 COG0397 O Protein adenylyltransferase (AMPylase) SelO/YdiU (selenoprotein O)
667 696 COG0409 O Hydrogenase maturation factor HypD
1436 2495 COG0425 J O H Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis)
2221 4601 COG0443 O Molecular chaperone DnaK (HSP70)
2261 3246 COG0459 O Chaperonin GroEL (HSP60 family)
2056 3230 COG0465 O ATP-dependent Zn proteases
1663 2256 COG0466 O ATP-dependent Lon protease, bacterial type
2230 6029 COG0484 O DnaJ molecular chaperone, contains DnaJ and DnaJ_C domains
2240 5650 COG0492 O Thioredoxin reductase
1763 3687 COG0501 O Zn-dependent protease with chaperone function
1758 5226 COG0526 O Thiol-disulfide isomerase or thioredoxin
2073 5306 COG0542 O ATP-dependent Clp protease, ATP-binding subunit ClpA
2055 2178 COG0544 O FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)
1216 2675 COG0545 O FKBP-type peptidyl-prolyl cis-trans isomerase
2215 2459 COG0576 O Molecular chaperone GrpE (heat shock protein HSP-70)
1753 2072 COG0606 O Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family
1659 2674 COG0616 O Periplasmic serine protease, ClpP class
981 8295 COG0625 O Glutathione S-transferase or stringent starvation protein SspA
360 887 COG0638 O 20S proteasome, alpha and beta subunits
691 1233 COG0641 O Sulfatase maturation enzyme AslB, radical SAM superfamily
1983 4027 COG0652 O Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
605 727 COG0678 O Peroxiredoxin
2079 2093 COG0691 O tmRNA-binding protein
1354 1809 COG0694 O Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain
1714 3219 COG0695 O Glutaredoxin
1695 3287 COG0705 O Membrane-associated serine protease, rhomboid family
1748 3376 COG0719 O Fe-S cluster assembly scaffold protein SufB
2050 3767 COG0740 O ATP-dependent protease ClpP, protease subunit
2182 2501 COG0750 K O Membrane-associated protease RseP, regulator of RpoE activity
1618 1940 COG0755 O ABC-type transport system involved in cytochrome c biogenesis, permease component
1676 4210 COG0760 O Peptidyl-prolyl isomerase, parvulin family
1172 1248 COG0762 O Cytochrome b6 maturation protein CCB3/Ycf19 and related maturases, YggT family
1041 1538 COG0785 O C Cytochrome c biogenesis protein CcdA
1868 4910 COG0793 O C-terminal processing protease CtpA/Prc, contains a PDZ domain
1818 2317 COG0822 O Fe-S cluster assembly scaffold protein IscU, NifU family
663 707 COG0829 O Urease accessory protein UreH
664 704 COG0830 O Urease accessory protein UreF
1500 1973 COG0846 O NAD-dependent protein deacetylase, SIR2 family
191 229 COG1025 O Secreted/periplasmic Zn-dependent peptidases, insulinase-like
286 303 COG1026 O Zn-dependent peptidase, M16 (insulinase) family
680 865 COG1030 O Membrane-bound serine protease NfeD, ClpP class
1131 1863 COG1047 O Peptidyl-prolyl cis-trans isomerase, FKBP type
714 903 COG1067 O Predicted ATP-dependent protease
735 925 COG1076 O DnaJ domain-containing protein
1584 2869 COG1086 M O NDP-sugar epimerase, includes UDP-GlcNAc-inverting 4,6-dehydratase FlaA1 and capsular polysaccharide biosynthesis protein EpsC
162 189 COG1123 O ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain
882 998 COG1138 O C Cytochrome c biogenesis protein CcmF
1128 2457 COG1180 O Pyruvate-formate lyase-activating enzyme
1983 2189 COG1219 O ATP-dependent protease Clp, ATPase subunit ClpX
1201 1204 COG1220 O ATP-dependent protease HslVU (ClpYQ), ATPase subunit HslU
498 699 COG1222 O ATP-dependent 26S proteasome regulatory subunit
1990 7435 COG1225 O Peroxiredoxin
1206 3847 COG1262 O Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain
1124 2043 COG1266 O Membrane protease YdiL, CAAX protease family
978 1749 COG1277 O ABC-type transport system involved in multi-copper enzyme maturation, permease component
1234 1245 COG1281 O Redox-regulated molecular chaperone, HSP33 family
255 342 COG1287 O Asparagine N-glycosylation enzyme, membrane subunit Stt3
836 863 COG1293 J O Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and RNA- (NFACT) binding domains
1622 4378 COG1305 O Transglutaminase-like enzyme, putative cysteine protease
632 799 COG1310 O Proteasome lid subunit RPN8/RPN11, contains Jab1/MPN domain metalloenzyme (JAMM) motif
671 736 COG1333 O C Cytochrome c biogenesis protein ResB
204 206 COG1382 O Prefoldin, chaperonin cofactor
1024 1039 COG1391 O Glutamine synthetase adenylyltransferase
866 1428 COG1397 O ADP-ribosylglycohydrolase
1432 5102 COG1404 O Serine protease, subtilisin family
605 1279 COG1433 O Predicted Fe-Mo cluster-binding protein, NifX family
1342 1972 COG1477 O H FAD:protein FMN transferase ApbE
894 1039 COG1495 O Disulfide bond formation protein DsbB
1049 1086 COG1585 O Membrane protein implicated in regulation of membrane protease activity
1489 3376 COG1651 O Protein thiol-disulfide isomerase DsbC
1947 11347 COG1670 J O Protein N-acetyltransferase, RimJ/RimL family
970 1441 COG1703 O GTPase of the G3E family (not a periplasmic protein kinase)
192 197 COG1730 O Prefoldin subunit 5
821 1922 COG1858 O Cytochrome c peroxidase
517 594 COG1899 J O Deoxyhypusine synthase
207 258 COG1913 O Archaemetzincin, Zn-dependent protease
340 366 COG1928 O Dolichyl-phosphate-mannose--protein O-mannosyl transferase
50 50 COG1973 O Hydrogenase maturation factor HypE
1135 1810 COG1975 O Molybdoenzyme maturation factor PaoD (Mo cofactor insertion), XdhC/CoxF family
1330 1847 COG1994 O Zn-dependent protease (includes sporulation protein SpoIVFB)
1151 2239 COG1999 O Cytochrome oxidase Cu insertion factor, SCO1/SenC/PrrC family
1055 1726 COG2020 O Protein-S-isoprenylcysteine O-methyltransferase Ste14
521 548 COG2039 O Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)
808 859 COG2077 O Peroxiredoxin
1339 1501 COG2127 O ATP-dependent Clp protease adapter protein ClpS
1553 1568 COG2137 O SOS response regulatory protein OraA/RecX, interacts with RecA
348 510 COG2143 O Thioredoxin-related protein SoxW
1411 2218 COG2151 O Metal-sulfur cluster biosynthetic enzyme
971 1063 COG2166 J O Sulfur transfer protein SufE/CsdE, Fe-S cluster assembly
739 1026 COG2170 O Gamma-glutamyl:cysteine ligase YbdK, ATP-grasp superfamily
391 433 COG2180 O C P Nitrate reductase assembly protein NarJ, required for insertion of molybdenum cofactor
980 3008 COG2234 O E Zn-dependent amino- or carboxypeptidase, M28 family
668 721 COG2317 O Zn-dependent carboxypeptidase, M32 family
402 476 COG2322 O Cytochrome oxidase assembly protein CtaM/YozB, DUF420 family
856 872 COG2332 O C Cytochrome c biogenesis protein CcmE
980 1477 COG2355 O E Zn-dependent dipeptidase, microsomal dipeptidase homolog
1117 1140 COG2360 O Leu/Phe-tRNA-protein transferase
317 386 COG2370 O Hydrogenase/urease accessory protein HupE
559 594 COG2371 O Urease accessory protein UreE
841 850 COG2386 O ABC-type transport system involved in cytochrome c biogenesis, permease component
1390 2333 COG2518 O Protein-L-isoaspartate O-methyltransferase
641 653 COG2738 O Zn-dependent membrane protease YugP
1123 1576 COG2761 O Predicted dithiol-disulfide isomerase, DsbA/YjbH family (virulence, stress resistance)
1073 1441 COG2825 M O Periplasmic chaperone for outer membrane proteins, Skp family
1003 1033 COG2844 T O UTP:GlnB (protein PII) uridylyltransferase
409 481 COG2846 O Iron-sulfur cluster repair protein YtfE, RIC family, contains ScdAN and hemerythrin domains
910 1417 COG2856 O Zn-dependent peptidase ImmA, M78 family
538 543 COG2924 O P Fe-S cluster biosynthesis and repair protein YggX
689 694 COG2935 O Arginyl-tRNA--protein-N-Asp/Glu arginylyltransferase
730 731 COG2938 O Succinate dehydrogenase flavin-adding protein, antitoxin component of the CptAB toxin-antitoxin module
489 491 COG2969 O Stringent starvation protein B, binds SsrA peptide
320 321 COG2975 O Fe-S-cluster formation regulator IscX/YfhJ
218 227 COG2991 O C Na+-NQR maturation protein NqrM
83 105 COG2994 O ACP:hemolysin acyltransferase (hemolysin-activating protein)
112 122 COG2999 O Glutaredoxin 2
270 303 COG3058 O C Formate dehydrogenase maturation protein FdhE
229 239 COG3062 O Cytoplasmic chaperone NapD for the signal peptide of periplasmic nitrate reductase NapAB
716 790 COG3088 O C Cytochrome c-type biogenesis protein CcmH/NrfF
2205 6058 COG3118 O Chaperedoxin CnoX, contains thioredoxin-like and TPR-like domains, YbbN/TrxSC family
499 506 COG3175 O C Cytochrome c oxidase assembly protein Cox11
676 903 COG3187 O Heat shock protein HslJ
698 725 COG3197 O Cytochrome oxidase maturation protein, CcoS/FixS family
491 679 COG3212 O PepSY domain containing protein, regulator of zincin peptidase activity
374 712 COG3227 O Zn-dependent metalloprotease (Neutral protease B)
499 737 COG3336 O C Cytochrome c oxidase assembly protein CtaG
726 955 COG3346 O Cytochrome oxidase assembly protein ShyY1
452 863 COG3381 O Cytoplasmic chaperone TorD involved in molybdoenzyme TorA maturation
109 113 COG3389 O Presenilin-like membrane protease, A22 family
424 441 COG3484 O Predicted proteasome-type protease
232 262 COG3531 O Predicted protein-disulfide isomerase, contains CxxC motif
257 350 COG3555 O Aspartyl/asparaginyl beta-hydroxylase, cupin superfamily
593 827 COG3590 O Predicted metalloendopeptidase
495 841 COG3591 O V8-like Glu-specific endopeptidase
221 391 COG3640 O CO dehydrogenase nickel-insertion accessory protein CooC1
319 489 COG3672 O Predicted transglutaminase-like protein
358 472 COG3678 O Periplasmic chaperone Spy, Spy/CpxP family
388 482 COG3751 J O Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain
322 332 COG3785 O Heat shock protein HspQ
294 296 COG3814 O SspB-like protein, predicted to bind SsrA peptide
338 358 COG3823 O Glutamine cyclotransferase
464 514 COG3824 O Predicted Zn-dependent protease, minimal metalloprotease (MMP)-like domain
348 350 COG3869 O Protein-arginine kinase McsB
357 373 COG3880 O Protein-arginine kinase activator protein McsA
334 395 COG3897 O Protein N-terminal and lysine N-methylase, NNT1/EFM7 family
372 777 COG3914 O Predicted O-linked N-acetylglucosamine transferase, SPINDLY family
626 633 COG4133 O ABC-type transport system involved in cytochrome c biogenesis, ATPase component
1152 1746 COG4232 O Thiol:disulfide interchange protein DsbD
452 504 COG4233 O C Thiol-disulfide interchange protein, contains DsbC and DsbD domains
1045 1593 COG4235 O C Cytochrome c-type biogenesis protein CcmH/NrfG
504 541 COG4260 O Membrane protease subunit, stomatin/prohibitin family, contains C-terminal Zn-ribbon domain
41 42 COG4346 O Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase
123 123 COG4357 O Membrane protein assembly factor Hot13, CHY-type Zn-finger domain
242 365 COG4412 O Bacillopeptidase F, M6 metalloprotease family
71 75 COG4545 O Glutaredoxin-related protein
94 95 COG4574 O Serine protease inhibitor ecotin
1572 6170 COG4783 M O Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains
319 424 COG4826 O Serine protease inhibitor
87 87 COG4837 O Disulfide oxidoreductase YuzD
304 455 COG4870 O Cysteine protease, C1A family
105 112 COG4875 O Protein kinase association domain CaMKII_AD, NTF2-like superfamily
181 199 COG4930 O Predicted ATP-dependent Lon-type protease
161 500 COG4934 O Serine protease, subtilase family
270 517 COG4935 O Regulatory P domain of the subtilisin-like proprotein convertases and other proteases
632 681 COG4987 O C ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components
729 840 COG4988 O C ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components
41 46 COG5029 O I Prenyltransferase, beta subunit
5 6 COG5054 O ERV1/ALR domain, mitochondrial thiol oxidase involved in protein folding and biogenesis of Fe/S clusters
45 63 COG5078 O Ubiquitin-protein ligase
51 51 COG5119 O Sulfiredoxin, contains ParB-like CTPase domain
19 19 COG5131 O Ubiquitin-like protein
4 4 COG5160 O Protease, Ulp1 family
5 8 COG5194 O RING finger domain of SCF ubiquitin ligase and anaphase-promoting complex
5 5 COG5206 O Glycosylphosphatidylinositol transamidase (GPIT), subunit GPI8
528 550 COG5265 O ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components
21 24 COG5272 O Ubiquitin
295 449 COG5282 O Zn-dependent metallopeptidase, zincin/DUF2342 superfamily
174 202 COG5331 O I Predicted lipid metabolism protein, MAPEG family
75 103 COG5380 O Lipase chaperone LimK
271 271 COG5387 O Mitochondrial FoF1-type ATP synthase assembly chaperone ATP12
1205 1247 COG5405 O ATP-dependent protease HslVU (ClpYQ), peptidase subunit
23 23 COG5494 O Predicted thioredoxin/glutaredoxin
132 161 COG5513 O Chagasin-like inhibitor of cysteine peptidase, I42 family
13 18 COG5533 O Ubiquitin C-terminal hydrolase
113 131 COG5549 O Predicted Zn-dependent protease
65 156 COG5550 O Predicted aspartyl protease
40 41 COG5580 O Activator of HSP90 ATPase
218 562 COG5640 O Secreted trypsin-like serine protease
353 431 COG5646 O P Iron-binding protein Fra/YdhG, frataxin family (Fe-S cluster biosynthesis)
85 87 COG5661 O Predicted secreted Zn-dependent protease
28 30 COG5664 O Predicted secreted Zn-dependent protease
74 74 COG5774 O C Cytochrome b6 maturation protein CCB1
75 75 COG5781 O C Cytochrome b6 maturation protein CCB2
233 233 COG5818 K D O Stage II sporulation protein SpoIIGA (protease, processing of pro-sigma-E to active sigma-E)
457 523 COG5832 D O Stage IV sporulation protein SpoIVB, serine protease, degrades SpoIIQ, SpoIVFA
133 143 COG5866 D O Sporulation-specific protease YabG