O - Posttranslational modification, protein turnover, chaperones

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COG definitions	Organims	Proteins	Median Protein Length	Genes
221	2,296	322,298	279.0	197

Organism	Protein	COG	Cat	Annotation
682	728	COG0068	O	Hydrogenase maturation factor HypF (carbamoyltransferase)
1880	4378	COG0071	O	Small heat shock protein IbpA, HSP20 family
389	466	COG0170	M O	Dolichol kinase
1919	2786	COG0225	O	Peptide methionine sulfoxide reductase MsrA
1834	2400	COG0229	O	Peptide methionine sulfoxide reductase MsrB
2066	2555	COG0234	O	Co-chaperonin GroES (HSP10)
2153	7517	COG0265	O	Periplasmic serine protease DegP/DegQ, contain C-terminal PDZ domain
957	1021	COG0278	O	Glutaredoxin-related protein
678	881	COG0298	O	Hydrogenase maturation factor HybG, HypC/HupF family
825	998	COG0309	O	Carbamoyl dehydratase HypE (hydrogenase maturation factor)
1209	3103	COG0312	V O	Zn-dependent protease or N-deacetylase, PmbA/TldD/TldE family
1682	3412	COG0316	O	Fe-S cluster assembly iron-binding protein IscA
1393	1629	COG0326	O	Molecular chaperone, HSP90 family
2054	5461	COG0330	O	Regulator of protease activity HflC, stomatin/prohibitin superfamily
1111	1415	COG0339	O	Zn-dependent oligopeptidase, M3 family
1162	1172	COG0354	J O	Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters, tRNA thiomethylation
720	831	COG0375	O	Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion
1130	1548	COG0378	O	Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase
1743	1811	COG0396	O	Fe-S cluster assembly ATPase SufC
931	982	COG0397	O	Protein adenylyltransferase (AMPylase) SelO/YdiU (selenoprotein O)
667	697	COG0409	O	Hydrogenase maturation factor HypD
1436	2495	COG0425	J O H	Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis)
2222	4618	COG0443	O	Molecular chaperone DnaK (HSP70)
2261	3248	COG0459	O	Chaperonin GroEL (HSP60 family)
2056	3244	COG0465	O	ATP-dependent Zn proteases
1663	2260	COG0466	O	ATP-dependent Lon protease, bacterial type
2231	6149	COG0484	O	DnaJ molecular chaperone, contains DnaJ and DnaJ_C domains
2240	5658	COG0492	O	Thioredoxin reductase
1766	3735	COG0501	O	Zn-dependent protease with chaperone function
1817	5837	COG0526	O	Thiol-disulfide isomerase or thioredoxin
2073	5360	COG0542	O	ATP-dependent Clp protease, ATP-binding subunit ClpA
2056	2185	COG0544	O	Trigger factor Tig, ribosome-bound chaperone (peptidyl-prolyl cis-trans isomerase)
1221	2727	COG0545	O	FKBP-type peptidyl-prolyl cis-trans isomerase
2216	2476	COG0576	O	Molecular chaperone GrpE (heat shock protein HSP-70)
1753	2077	COG0606	O	Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family
1659	2674	COG0616	O	Periplasmic serine protease, ClpP class
981	8383	COG0625	O	Glutathione S-transferase or stringent starvation protein SspA
360	887	COG0638	O	20S proteasome, alpha and beta subunits
699	1262	COG0641	O	Sulfatase maturation enzyme AslB, radical SAM superfamily
1984	4034	COG0652	O	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
605	727	COG0678	O	Peroxiredoxin
2080	2093	COG0691	O	tmRNA-binding protein
1357	1810	COG0694	O	Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain
1715	3219	COG0695	O	Glutaredoxin
1725	3572	COG0705	O	Membrane-associated serine protease, rhomboid family
1748	3376	COG0719	O	Fe-S cluster assembly scaffold protein SufB
2050	3774	COG0740	O	ATP-dependent protease ClpP, protease subunit
2198	2554	COG0750	K O	Membrane-associated protease RseP, regulator of RpoE activity
1625	1962	COG0755	O	ABC-type transport system involved in cytochrome c biogenesis, permease component
1749	4734	COG0760	O	Periplasmic chaperone SurA (peptidyl-prolyl cis-trans isomerase)
1249	1325	COG0762	O	Cytochrome b6 maturation protein CCB3/Ycf19 and related maturases, YggT family
1082	1610	COG0785	O C	Cytochrome c biogenesis protein CcdA
1870	5004	COG0793	O	C-terminal processing protease CtpA/Prc, contains a PDZ domain
1823	2325	COG0822	O	Fe-S cluster assembly scaffold protein IscU, NifU family
663	708	COG0829	O	Urease accessory protein UreD/UreH
665	706	COG0830	O	Urease accessory protein UreF
1501	1976	COG0846	O	NAD-dependent protein deacetylase, SIR2 family
191	229	COG1025	O	Secreted/periplasmic Zn-dependent peptidases, insulinase-like
286	303	COG1026	O	Zn-dependent peptidase, M16 (insulinase) family
694	906	COG1030	O	Membrane-bound serine protease NfeD, ClpP class
1132	1868	COG1047	O	Peptidyl-prolyl cis-trans isomerase, FKBP type
714	907	COG1067	O	Predicted ATP-dependent protease
775	976	COG1076	O	DnaJ domain-containing protein
162	189	COG1123	O	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain
882	999	COG1138	O C	Cytochrome c biogenesis protein CcmF
1128	2459	COG1180	O	Pyruvate-formate lyase-activating enzyme
1984	2202	COG1219	O	ATP-dependent protease Clp, ATPase subunit ClpX
1201	1204	COG1220	O	ATP-dependent protease HslVU (ClpYQ), ATPase subunit HslU
498	702	COG1222	O	ATP-dependent 26S proteasome regulatory subunit
1997	7836	COG1225	O	Peroxiredoxin
1211	3885	COG1262	O	Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain
1528	4011	COG1266	O	Membrane protease YdiL, CAAX protease family
1223	2497	COG1277	O	ABC-type transport system involved in multi-copper enzyme maturation, permease component
1235	1245	COG1281	O	Redox-regulated molecular chaperone, HSP33 family
291	401	COG1287	O	Asparagine N-glycosylation enzyme, membrane subunit Stt3
836	864	COG1293	J O	Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and RNA- (NFACT) binding domains
1647	4589	COG1305	O	Transglutaminase-like enzyme, putative cysteine protease
665	854	COG1310	O	Predicted metalloprotease (deubiquitase), contains Jab1/MPN domain metalloenzyme (JAMM) motif
693	779	COG1333	O C	Cytochrome c biogenesis protein ResB
204	206	COG1382	O	Prefoldin, chaperonin cofactor
1024	1039	COG1391	O	Glutamine synthetase adenylyltransferase
879	1473	COG1397	O	ADP-ribosylglycohydrolase
1562	5926	COG1404	O	Serine protease, subtilisin family
654	1591	COG1433	O	Predicted Fe-Mo cluster-binding protein, NifX family
1342	1972	COG1477	O H	FAD:protein FMN transferase ApbE
908	1060	COG1495	O	Disulfide bond formation protein DsbB
1134	1181	COG1585	O	Membrane protein implicated in regulation of membrane protease activity
1511	3629	COG1651	O	Protein thiol-disulfide isomerase DsbC
1955	11570	COG1670	J O	Protein N-acetyltransferase, RimJ/RimL family
970	1441	COG1703	O	GTPase of the G3E family (not a periplasmic protein kinase)
194	199	COG1730	O	Prefoldin subunit 5
1318	3539	COG1807	M O	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA
825	1955	COG1858	O	Cytochrome c peroxidase
517	594	COG1899	J O	Deoxyhypusine synthase
220	275	COG1913	O	Archaemetzincin, Zn-dependent protease
341	368	COG1928	O	Dolichyl-phosphate-mannose--protein O-mannosyl transferase
613	803	COG1944	O	Peptide backbone phosphorylating domain YcaO, involved in protein thioamidation and methylthiolation
50	50	COG1973	O	Hydrogenase maturation factor HypE
1136	1816	COG1975	O	Molybdoenzyme maturation factor PaoD (Mo cofactor insertion), XdhC/CoxF family
1432	2151	COG1994	O	Zn-dependent protease (includes sporulation protein SpoIVFB)
1152	2302	COG1999	O	Cytochrome oxidase Cu insertion factor, SCO1/SenC/PrrC family
1087	1814	COG2020	O	Protein-S-isoprenylcysteine O-methyltransferase Ste14
532	563	COG2039	O	Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)
809	860	COG2077	O	Peroxiredoxin
1348	1512	COG2127	O	ATP-dependent Clp protease adapter protein ClpS
1564	1581	COG2137	O	SOS response regulatory protein OraA/RecX, interacts with RecA
427	746	COG2143	O	Thioredoxin-related protein SoxW
1411	2221	COG2151	O	Metal-sulfur cluster biosynthetic enzyme, includes PaaD subunit of phenylacetate degradation complex
972	1064	COG2166	J O	Sulfur transfer protein SufE/CsdE, Fe-S cluster assembly
759	1174	COG2170	O	Gamma-glutamyl:cysteine ligase YbdK, ATP-grasp superfamily
391	433	COG2180	O C P	Nitrate reductase assembly protein NarJ, required for insertion of molybdenum cofactor
996	3054	COG2234	O E	Zn-dependent amino- or carboxypeptidase, M28 family
668	721	COG2317	O	Zn-dependent carboxypeptidase, M32 family
404	479	COG2322	O	Cytochrome oxidase assembly protein CtaM/YozB, DUF420 family
866	882	COG2332	O C	Cytochrome c biogenesis protein CcmE
980	1494	COG2355	O E	Zn-dependent dipeptidase, microsomal dipeptidase homolog
1117	1142	COG2360	O	Leu/Phe-tRNA-protein transferase
386	487	COG2370	O	Hydrogenase/urease accessory protein HupE
560	595	COG2371	O	Urease accessory protein UreE
865	874	COG2386	O	ABC-type transport system involved in cytochrome c biogenesis, permease component
1390	2335	COG2518	O	Protein-L-isoaspartate O-methyltransferase
643	655	COG2738	O	Zn-dependent membrane protease YugP
1136	1627	COG2761	O	Predicted dithiol-disulfide isomerase, DsbA/YjbH family (virulence, stress resistance)
1175	1755	COG2825	M O	Periplasmic chaperone for outer membrane proteins, Skp/HlpA/OmpH family
1005	1038	COG2844	T O	UTP:GlnB (protein PII) uridylyltransferase
452	546	COG2846	O	Iron-sulfur cluster repair protein YtfE, RIC family, contains ScdAN and hemerythrin domains
966	1581	COG2856	O	Zn-dependent peptidase ImmA, M78 family
538	544	COG2924	O P	Fe-S cluster biosynthesis and repair protein YggX
689	694	COG2935	O	Arginyl-tRNA--protein-N-Asp/Glu arginylyltransferase
732	733	COG2938	O	Succinate dehydrogenase flavin-adding protein, antitoxin component of the CptAB toxin-antitoxin module
417	555	COG2940	O	Histone-lysine N-methyltransferase, H3-specific, SET domain
498	501	COG2969	O	Stringent starvation protein B, binds SsrA peptide
320	321	COG2975	O	Fe-S-cluster formation regulator IscX/YfhJ
218	227	COG2991	O C	Na+-NQR maturation protein NqrM
84	106	COG2994	O	ACP:protein(Lys) acyltransferase, toxin activator, CyaC/HlyC family
112	122	COG2999	O	Glutaredoxin 2
271	305	COG3058	O C	Formate dehydrogenase maturation protein FdhE
239	249	COG3062	O	Cytoplasmic chaperone NapD for the signal peptide of periplasmic nitrate reductase NapAB
719	796	COG3088	O C	Cytochrome c-type biogenesis protein CcmH/NrfF
2219	6493	COG3118	O	Chaperedoxin CnoX, contains thioredoxin-like and TPR-like domains, YbbN/TrxSC family
499	507	COG3175	O C	Cytochrome c oxidase assembly protein Cox11
699	945	COG3187	O	Heat shock protein HslJ
698	725	COG3197	O	Cytochrome oxidase maturation protein, CcoS/FixS family
491	680	COG3212	O	PepSY domain containing protein, regulator of zincin peptidase activity
390	760	COG3227	O	Zn-dependent metalloprotease (Neutral protease B)
508	755	COG3336	O C	Cytochrome c oxidase assembly protein CtaG
728	969	COG3346	O	Cytochrome oxidase assembly protein ShyY1
455	884	COG3381	O	Cytoplasmic chaperone TorD involved in molybdoenzyme TorA maturation
109	113	COG3389	O	Presenilin-like membrane protease, A22 family
96	113	COG3482	O	TfuA-related peptide backbone thioamidation domain
424	441	COG3484	O	Predicted proteasome-type protease
233	263	COG3531	O	Predicted protein-disulfide isomerase, contains CxxC motif
265	366	COG3555	O	Aspartyl/asparaginyl beta-hydroxylase, cupin superfamily,includes lipid A hydroxylase LpxO
593	828	COG3590	O	Endopeptidase PepO, M13 family
636	1218	COG3591	O	V8-like Glu-specific endopeptidase
235	410	COG3640	O	CO dehydrogenase nickel-insertion accessory protein CooC1
334	517	COG3672	O	Predicted transglutaminase-like protein
582	876	COG3678	O	Periplasmic chaperone Spy, Spy/CpxP family
510	672	COG3751	J O	Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain
322	332	COG3785	O	Heat shock protein HspQ
294	296	COG3814	O	SspB-like protein, predicted to bind SsrA peptide
338	358	COG3823	O	Glutamine cyclotransferase
474	596	COG3824	O	Predicted Zn-dependent protease zincin, minimal metalloprotease (MMP)-like domain
349	350	COG3869	O	Protein-arginine kinase McsB
359	399	COG3880	O	Protein-arginine kinase activator protein McsA
343	407	COG3897	O	Protein N-terminal and lysine N-methylase, NNT1/EFM7 family
1010	2297	COG3914	O	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family
626	633	COG4133	O	ABC-type transport system involved in cytochrome c biogenesis, ATPase component
1153	1766	COG4232	O	Thiol:disulfide interchange protein DsbD
455	507	COG4233	O C	Thiol-disulfide interchange protein, contains DsbC and DsbD domains
1108	1797	COG4235	O C	Cytochrome c-type biogenesis protein CcmH/NrfG
505	543	COG4260	O	Membrane protease subunit, stomatin/prohibitin family, contains C-terminal Zn-ribbon domain
42	43	COG4346	O	Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase
124	124	COG4357	O	Membrane protein assembly factor Hot13, CHY-type Zn-finger domain
282	464	COG4412	O	Bacillopeptidase F, M6 metalloprotease family
71	75	COG4545	O	Glutaredoxin-related protein
94	95	COG4574	O	Serine protease inhibitor ecotin
312	318	COG4769	O H	Protein flavinylation system FAD exporter subunit EetB
1587	6318	COG4783	M O	Periplasmic chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains
324	432	COG4826	O	Serine protease inhibitor
87	87	COG4837	O	Disulfide oxidoreductase YuzD
340	523	COG4870	O	Cysteine protease, C1A family
121	129	COG4875	O	Protein kinase association domain CaMKII_AD, NTF2-like superfamily
182	200	COG4930	O	Predicted ATP-dependent Lon-type protease
164	509	COG4934	O	Serine protease, subtilase family
276	526	COG4935	O	Regulatory P domain of the subtilisin/kexin-like proprotein convertases
632	682	COG4987	O C	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components
729	840	COG4988	O C	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components
95	166	COG5029	O I	Prenyltransferase, beta subunit
5	6	COG5054	O	ERV1/ALR domain, mitochondrial thiol oxidase involved in protein folding and biogenesis of Fe/S clusters
49	67	COG5078	O	Ubiquitin-protein ligase
53	53	COG5119	O	Sulfiredoxin, contains ParB-like CTPase domain
21	21	COG5131	O	Ubiquitin-like protein
9	12	COG5160	O	Protease, Ulp1 family
5	8	COG5194	O	RING finger domain of SCF ubiquitin ligase and anaphase-promoting complex
10	10	COG5206	O	Glycosylphosphatidylinositol transamidase (GPIT), subunit GPI8
529	551	COG5265	O	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components
24	27	COG5272	O	Ubiquitin
295	450	COG5282	O	Zn-dependent metallopeptidase, zincin/DUF2342 superfamily
178	215	COG5331	O I	Predicted lipid metabolism protein, MAPEG family
84	125	COG5380	O	Lipase chaperone LimK
271	271	COG5387	O	Mitochondrial FoF1-type ATP synthase assembly chaperone ATP12
1207	1247	COG5405	O	ATP-dependent protease HslVU (ClpYQ), peptidase subunit
23	24	COG5494	O	Predicted thioredoxin/glutaredoxin
155	190	COG5513	O	Chagasin-like inhibitor of cysteine peptidase, I42 family
15	27	COG5533	O	Ubiquitin C-terminal hydrolase
181	223	COG5549	O	Predicted Zn-dependent protease
99	231	COG5550	O	Predicted aspartyl protease
58	60	COG5580	O	SRPBCC-like C-terminal domain of Aha1, activator of Hsp90 ATPase
304	771	COG5640	O	Secreted trypsin-like serine protease
515	723	COG5646	O P	Iron-binding protein Fra/YdhG, frataxin family (Fe-S cluster biosynthesis)
97	99	COG5661	O	Predicted secreted Zn-dependent protease
28	30	COG5664	O	Predicted secreted Zn-dependent protease, DUF922 domain
74	74	COG5774	O C	Cytochrome b6 maturation protein CCB1
75	75	COG5781	O C	Cytochrome b6 maturation protein CCB2
233	233	COG5818	K D O	Stage II sporulation protein SpoIIGA (protease, processing of pro-sigma-E to active sigma-E)
457	523	COG5832	D O	Stage IV sporulation protein SpoIVB, serine protease, degrades SpoIIQ, SpoIVFA
133	143	COG5866	D O	Sporulation-specific protease YabG
399	625	COG5985	O	Archaeal-like signal peptidase I, S24/S26 peptidase family
71	98	COG5986	O	Acid stress chaperone HdeA, HdeA/HdeB family
216	226	COG6144	O	C-terminal protein-protein interaction domain of YcaO, involved in S12 methylthiotransferase activity of RimO