M - Cell wall/membrane/envelope biogenesis

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COG definitions	Organims	Proteins	Median Protein Length	Genes
246	2,295	429,876	361.0	236

Organism	Protein	COG	Cat	Annotation
301	352	COG0170	M O	Dolichol kinase
2114	5103	COG0329	M E	4-hydroxy-tetrahydrodipicolinate synthase/N-acetylneuraminate lyase
1352	1964	COG0381	M	UDP-N-acetylglucosamine 2-epimerase
901	1299	COG0392	M	Predicted membrane flippase AglD2/YbhN, UPF0104 family
1799	4857	COG0399	M	dTDP-4-amino-4,6-dideoxygalactose transaminase
303	347	COG0434	M	Membrane biogenesis protein, BtpA/SgcQ family
2199	29347	COG0438	M	Glycosyltransferase involved in cell wall bisynthesis
2139	2643	COG0449	M	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains
2134	16200	COG0451	M	Nucleoside-diphosphate-sugar epimerase
2198	17824	COG0463	M	Glycosyltransferase involved in cell wall bisynthesis
1254	2738	COG0464	D T M	AAA+-type ATPase, SpoVK/Ycf46/Vps4 family
2133	3820	COG0472	M	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase
473	512	COG0562	M	UDP-galactopyranose mutase
1603	3496	COG0586	M	Undecaprenyl phosphate translocase (flippase), DedA/Tvp38 family
2030	2344	COG0597	M U	Lipoprotein signal peptidase
490	537	COG0615	M	Glycerol-3-phosphate cytidylyltransferase, cytidylyltransferase family
1935	4296	COG0668	M	Small-conductance mechanosensitive channel
1321	1782	COG0677	M	UDP-N-acetyl-D-mannosaminuronate dehydrogenase
2027	2450	COG0682	M	Prolipoprotein diacylglyceryltransferase
2072	2328	COG0706	M	Membrane protein insertase Oxa1/YidC/SpoIIIJ
2064	2822	COG0707	M	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase
1852	6321	COG0726	M G	Peptidoglycan/xylan/chitin deacetylase, PgdA/NodB/CDA1 family
1617	1981	COG0728	M	Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis)
803	899	COG0729	M	Outer membrane translocation and assembly module TamA
1814	5282	COG0739	M	Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain
1556	4304	COG0741	M U	Soluble lytic murein transglycosylase or regulatory protein ( may contain LysM/invasin domain), , includes type III secretion system proteins IagB/IpgF/YsaH
1715	3543	COG0744	M	Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase
1943	2056	COG0759	M	Membrane-anchored protein YidD, putatitve component of membrane protein insertase Oxa1/YidC/SpoIIIJ
1265	1359	COG0763	M	Lipid A disaccharide synthetase
2007	2445	COG0766	M	UDP-N-acetylglucosamine enolpyruvyl transferase
1343	2373	COG0767	M	Permease subunit MlaE of the ABC-type intermembrane phospholipid transporter Mla
2023	5041	COG0768	D M	Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2)
2044	3002	COG0769	M	UDP-N-acetylmuramyl tripeptide synthase
2055	2353	COG0770	M	UDP-N-acetylmuramyl pentapeptide synthase
2011	2067	COG0771	M	UDP-N-acetylmuramoylalanine-D-glutamate ligase
2009	2768	COG0773	M	UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family
1279	1295	COG0774	M	UDP-3-O-acyl-N-acetylglucosamine deacetylase
1941	2379	COG0787	M	Alanine racemase
1599	4245	COG0791	M	Cell wall-associated hydrolase, NlpC_P60 family
1416	1660	COG0794	M G	D-arabinose 5-phosphate isomerase GutQ
1361	2725	COG0795	M N	Lipopolysaccharide export LptBFGC system, permease protein LptF
1700	1779	COG0796	M	Glutamate racemase
1039	1452	COG0797	M	Peptidoglycan lytic transglycosylase RlpA, contains C-terminal SPOR domain
1307	4212	COG0810	M	Periplasmic protein TonB, links inner and outer membranes
2026	2114	COG0812	M	UDP-N-acetylenolpyruvoylglucosamine reductase
1404	1622	COG0815	M	Apolipoprotein N-acyltransferase
1465	1697	COG0836	M	Mannose-1-phosphate guanylyltransferase
1713	11708	COG0845	V M	Multidrug efflux pump subunit AcrA (membrane-fusion protein)
1098	3450	COG0859	M	ADP-heptose:LPS heptosyltransferase
1758	3474	COG0860	M	N-acetylmuramoyl-L-alanine amidase
1705	2205	COG1004	M	UDP-glucose 6-dehydrogenase
1325	1516	COG1043	M	Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase
1463	1984	COG1044	M	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
576	722	COG1083	M	CMP-N-acetylneuraminic acid synthetase, NeuA/PseF family
1584	2869	COG1086	M O	NDP-sugar epimerase, includes UDP-GlcNAc-inverting 4,6-dehydratase FlaA1 and capsular polysaccharide biosynthesis protein EpsC
1832	2385	COG1087	M	UDP-glucose 4-epimerase
1686	2037	COG1088	M	dTDP-D-glucose 4,6-dehydratase
926	1261	COG1089	M	GDP-D-mannose dehydratase
1578	2117	COG1091	M	dTDP-4-dehydrorhamnose reductase
1344	2000	COG1127	M	ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla
2224	10649	COG1136	M	ABC-type lipoprotein export system, ATPase component
1352	1369	COG1137	M	ABC-type lipopolysaccharide export system, ATPase component
2035	3482	COG1181	M R	D-alanine-D-alanine ligase or related ATP-grasp enzyme
1996	2332	COG1207	M	Bifunctional protein GlmU, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase
1563	3090	COG1208	J M	NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis protein s
1723	2427	COG1209	M	dTDP-glucose pyrophosphorylase
1508	1845	COG1210	M	UTP-glucose-1-phosphate uridylyltransferase
1216	1279	COG1212	M	CMP-2-keto-3-deoxyoctulosonic acid synthetase
1160	1178	COG1286	M F	Colicin V production accessory protein CvpA, regulator of purF expression and biofilm formation
837	1784	COG1292	M	Choline-glycine betaine transporter
798	2349	COG1316	M	Anionic cell wall polymer biosynthesis enzyme TagV/TagU, LytR-Cps2A-Psr (LCP) family (peptidoglycan teichoic acid transferase)
672	794	COG1346	M	Putative effector of murein hydrolase
796	1329	COG1368	M	Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily
1259	3525	COG1376	M	Lipoprotein-anchoring transpeptidase ErfK/SrfK
1335	2778	COG1388	M	LysM repeat
163	184	COG1422	M	Archaeal YidC/Oxa1 membrane insertase, DUF106 family
1293	1987	COG1434	M	Lipid carrier protein ElyC involved in cell wall biogenesis, DUF218 family
350	503	COG1442	M	Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase
1339	1409	COG1452	M	LPS assembly protein LptD/OstA, potential outer membrane flippase
1351	3170	COG1463	M	Periplasmic subunit MlaD of the ABC-type intermembrane phospholipid transporter Mla
1172	1291	COG1519	M	3-deoxy-D-manno-octulosonic-acid transferase
1229	3533	COG1520	M	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat
1449	10050	COG1538	M	Outer membrane protein TolC
1837	1982	COG1559	M	Endolytic transglycosylase MltG, terminates peptidoglycan polymerization
1124	2562	COG1596	M	Periplasmic protein Wza involved in polysaccharide export, contains SLBB domain of the beta-grasp fold
960	1249	COG1619	M	Muramoyltetrapeptide carboxypeptidase LdcA (peptidoglycan recycling)
1176	1179	COG1663	M	Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase)
1445	3167	COG1686	M	D-alanyl-D-alanine carboxypeptidase
790	1273	COG1696	M	D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily
1279	1611	COG1704	M	Magnetosome formation protein MamQ, lipoprotein antigen LemA family
666	911	COG1705	M N	Flagellum-specific peptidoglycan hydrolase FlgJ
827	1108	COG1732	M	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)
957	1046	COG1778	M R	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC and related HAD superfamily phosphatases
760	967	COG1794	M	Amino acid racemase YgeA
1239	2994	COG1807	M	PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA
13	21	COG1822	M	Uncharacterized membrane protein MJ0419, predicted role in archaeal polysaccharide biosynthesis
1228	3354	COG1835	M	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains
273	322	COG1861	M	Spore coat polysaccharide biosynthesis protein SpsF, cytidylyltransferase family
762	1090	COG1876	M	LD-carboxypeptidase LdcB, LAS superfamily
451	881	COG1887	M I	CDP-glycerol glycerophosphotransferase, TagB/SpsB family
1575	2168	COG1898	M	dTDP-4-dehydrorhamnose 3,5-epimerase or related enzyme
973	1265	COG1922	M	UDP-N-acetyl-D-mannosaminuronic acid transferase, WecB/TagA/CpsF family
1070	1090	COG1934	M	Lipopolysaccharide export system protein LptA
1384	1479	COG1970	M	Large-conductance mechanosensitive channel
1020	1272	COG2027	M	D-alanyl-D-alanine carboxypeptidase
558	656	COG2035	M	Undecaprenyl phosphate translocase (flippase), DUF368 family
370	383	COG2052	M	Regulator of extracellular matrix RemA, YlzA/DUF370 family
726	939	COG2089	M	Sialic acid synthase SpsE, contains C-terminal SAF domain
798	908	COG2103	M	N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase
1173	2497	COG2132	D M P	Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA)
1796	4115	COG2148	M	Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid)
584	653	COG2173	M	D-alanyl-D-alanine dipeptidase
411	699	COG2194	M	Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily
562	789	COG2222	M	Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain
1811	4812	COG2244	M	Membrane protein involved in the export of O-antigen and teichoic acid
79	825	COG2247	M	Putative cell wall-binding domain (amidase enhancer), LytB superfamily
723	914	COG2327	M	Polysaccharide pyruvyl transferase family protein WcaK (colanic acid biosynthesis)
465	649	COG2348	M	Lipid II:glycine glycyltransferase (Peptidoglycan interpeptide bridge formation enzyme)
1052	1072	COG2377	M	1,6-Anhydro-N-acetylmuramate kinase
575	944	COG2385	M	Peptidoglycan hydrolase (amidase) enhancer domain SpoIID
948	1607	COG2815	M	PASTA domain, binds beta-lactams
670	717	COG2821	M	Membrane-bound lytic murein transglycosylase
836	1713	COG2823	M	Phospholipid-binding membrane integrity protein DolP/YraP/OsmY, contains BON domain
1073	1441	COG2825	M O	Periplasmic chaperone for outer membrane proteins, Skp family
357	378	COG2829	M	Outer membrane phospholipase A
1418	1784	COG2834	M	Outer membrane lipoprotein-sorting protein
732	1019	COG2843	M	Poly-gamma-glutamate biosynthesis protein CapA/YwtB (capsule formation), metallophosphatase superfamily
177	210	COG2845	M	Peptidoglycan O-acetyltransferase, SGNH hydrolase family
706	786	COG2853	M	Lipoprotein subunit MlaA of the ABC-type intermembrane phospholipid transporter Mla
731	909	COG2854	M	Periplasmic subunit MlaC of the ABC-type intermembrane phospholipid transporter Mla
250	256	COG2859	M	Outer membrane channel-forming protein BP26/OMP28, SIMPL family
681	1010	COG2866	M	Murein tripeptide amidase MpaA
926	1460	COG2870	M	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase
1200	1217	COG2877	M	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase
1405	7590	COG2885	M	Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins
644	644	COG2891	M	Cell shape-determining protein MreD
1001	1377	COG2908	M	UDP-2,3-diacylglucosamine pyrophosphatase LpxH
795	920	COG2913	M	Outer membrane protein assembly factor BamE, lipoprotein component of the BamABCDE complex
374	427	COG2943	M G	Membrane glycosyltransferase
446	492	COG2949	M	Uncharacterized periplasmic protein SanA, affects membrane permeability for vancomycin
967	1673	COG2951	M	Membrane-bound lytic murein transglycosylase B
925	1415	COG2956	M	Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain
489	489	COG2980	M	Outer membrane lipoprotein LptE/RlpB (LPS assembly)
807	1260	COG2982	M	Uncharacterized conserved protein AsmA involved in outer membrane biogenesis
572	840	COG2989	M	Murein L,D-transpeptidase YcbB/YkuD
454	758	COG2995	M	Intermembrane transporter PqiABC subunit PqiA
429	533	COG3008	M	Intermembrane transporter PqiABC subunit PqiB
393	437	COG3009	M	Intermembrane transporter PqiABC lipoprotein subunit PqiC
191	208	COG3015	V M	Uncharacterized lipoprotein NlpE involved in copper resistance
466	467	COG3017	M	Outer membrane lipoprotein LolB, involved in outer membrane biogenesis
1126	1566	COG3023	M	N-acetyl-anhydromuramyl-L-alanine amidase AmpD
615	793	COG3034	M	Murein L,D-transpeptidase YafK
446	523	COG3040	M	Bacterial lipocalin Blc
491	626	COG3047	M	Outer membrane protein OmpW
418	578	COG3049	M R	Penicillin V acylase or related amidase, Ntn superfamily
345	590	COG3055	M	N-acetylneuraminic acid mutarotase
673	1037	COG3064	M	Membrane protein TolA involved in colicin uptake
178	244	COG3065	M	Starvation-inducible outer membrane lipoprotein Slp
208	238	COG3083	T M	Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily
373	378	COG3107	M	Outer membrane lipoprotein LpoA, binds and activates PBP1a
509	653	COG3113	M	MlaB (STAS domain) subunit of the ABC-type intermembrane phospholipid transporter Mla
601	603	COG3117	M	Lipopolysaccharide export system protein LptC
341	533	COG3131	M	Periplasmic glucan biosynthesis protein OpgG
325	398	COG3133	M	Outer membrane lipoprotein SlyB
383	461	COG3137	M	Putative salt-induced outer membrane protein YdiY
608	626	COG3164	M	Phospholipid transporter to the outer membrane, contains AsmA2 domain
456	1806	COG3203	M	Outer membrane porin OmpC/OmpF/PhoE
1110	2709	COG3206	M	Exopolysaccharide export protein/domain GumC/Wzc1
163	193	COG3248	M	Nucleoside-specific outer membrane channel protein Tsx
461	642	COG3254	M	L-rhamnose mutarotase
1390	2777	COG3264	M	Small-conductance mechanosensitive channel MscK
284	348	COG3274	M	Surface polysaccharide O-acyltransferase WecH
276	397	COG3306	M	Glycosyltransferase involved in LPS biosynthesis, GR25 family
909	1339	COG3307	M	O-antigen ligase
428	436	COG3317	M	Outer membrane beta-barrel protein assembly factor BamC
928	2351	COG3409	M	Peptidoglycan-binding (PGRP) domain of peptidoglycan hydrolases
221	232	COG3417	M	Outer membrane lipoprotein LpoB, binds and activates PBP1b
158	515	COG3468	M U	Autotransporter adhesin AidA
137	142	COG3470	M I	Uncharacterized conserved protein probably involved in high-affinity Fe2+ transport
440	443	COG3494	M	UDP-2,3-diacylglucosamine hydrolase LpxI, combines lipid X-binding and nucleotide phosphodiesterase domains
326	647	COG3511	M	Phospholipase C
292	388	COG3524	M	Capsule polysaccharide export protein KpsE/RkpR
219	251	COG3528	M	Lipid A deacylase LpxR, DUF2219 family
231	273	COG3562	M	Capsule polysaccharide modification protein KpsS
208	238	COG3563	M	Capsule polysaccharide export protein KpsC/LpsZ
148	215	COG3589	M	6-phospho-N-acetylmuramidase MupG, DUF871 family
460	1343	COG3637	M	Opacity protein LomR and related surface antigens
288	538	COG3659	M	Carbohydrate-selective porin OprB
421	659	COG3713	M	Outer membrane scaffolding protein for murein synthesis, MipA/OmpV family
260	359	COG3754	M	Lipopolysaccharide biosynthesis protein
537	896	COG3757	M	Lyzozyme M1 (1,4-beta-N-acetylmuramidase), GH25 family
594	1303	COG3764	M	Sortase (surface protein transpeptidase)
184	259	COG3765	M	LPS O-antigen chain length determinant protein, WzzB/FepE family
323	371	COG3770	M	Murein endopeptidase MepA (D-alanyl-D-alanine-endopeptidase)
142	142	COG3771	M	Lipopolysaccharide assembly protein YciS/LapA, DUF1049 family
390	644	COG3772	M	Phage-related lysozyme (muramidase), GH24 family
515	1028	COG3773	D M	Cell wall hydrolase CwlJ, involved in spore germination
261	337	COG3774	M	Mannosyltransferase OCH1 or related enzyme
364	391	COG3786	M	L,D-peptidoglycan transpeptidase YkuD, ErfK/YbiS/YcfS/YnhG family
397	623	COG3875	M	Nickel-dependent lactate racemase
556	660	COG3876	M	Exo-beta-N-acetylmuramidase YbbC/NamZ, DUF1343 family
240	253	COG3895	M	Membrane-bound inhibitor of C-type lysozyme
339	504	COG3932	M	Exopolysaccharide synthesis protein ExoD
184	320	COG3942	M	Surface antigen
444	703	COG3944	M	Capsular polysaccharide biosynthesis protein YveK
33	34	COG3955	M	Uncharacterized conserved protein, DUF1919 family
86	91	COG3966	M	Poly-D-alanine transfer protein DltD, involved in esterification of teichoic acids
230	276	COG3967	M I	Short-chain dehydrogenase involved in D-alanine esterification of teichoic acids
342	368	COG3980	M	Spore coat polysaccharide biosynthesis protein SpsG, predicted glycosyltransferase
12	12	COG4092	M	Predicted glycosyltransferase involved in capsule biosynthesis
1250	1476	COG4105	M	Outer membrane protein assembly factor BamD, BamD/ComL family
101	108	COG4238	M	Outer membrane murein-binding lipoprotein Lpp
87	89	COG4267	M	PelG component of the PelDEFG exopolysaccharide exporter complex
108	140	COG4282	M	Cell wall assembly regulator SMI1 (Killer toxin-resistance protein 4)
54	64	COG4305	M	Peptidoglycan-binding domain, expansin YoaJ
212	322	COG4313	M	Sphingosine uptake channel SphA-related outer membrane channel
182	331	COG4409	M G	Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain
233	371	COG4421	M	Capsular polysaccharide biosynthesis protein
112	145	COG4424	M	LPS sulfotransferase NodH
201	272	COG4520	M	Surface antigen
60	68	COG4571	M	Outer membrane protease
39	42	COG4588	M	Accessory colonization factor AcfC, contains ABC-type periplasmic domain
2002	6487	COG4591	M	ABC-type transport system involved in lipoprotein release, permease component LolC
638	954	COG4623	T M	Membrane-bound lytic murein transglycosylase MltF
119	151	COG4678	M X	Muramidase (phage lambda lysozyme)
228	348	COG4692	M G	Predicted neuraminidase (sialidase)
73	106	COG4750	M I	CTP:phosphocholine cytidylyltransferase LicC
1402	2872	COG4775	M	Outer membrane protein assembly factor BamA
1572	6170	COG4783	M O	Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains
331	399	COG4785	M	Lipoprotein NlpI, contains TPR repeats
333	378	COG4864	M	Flotillin-like protein FloA/YqfA, UPF0365 family
341	724	COG4932	M	Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold
1481	5489	COG4948	M R	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily
316	353	COG4952	M	L-rhamnose isomerase
580	615	COG4953	M	Membrane carboxypeptidase/penicillin-binding protein PbpC
1183	1422	COG5009	M	Membrane carboxypeptidase/penicillin-binding protein
104	120	COG5039	M G	Exopolysaccharide biosynthesis protein EpsI, predicted pyruvyl transferase
236	371	COG5337	M	Spore coat protein CotH
285	286	COG5375	M	Predicted lipopolysaccharide assembly protein, LptC/YrbK-like family
74	130	COG5435	M	Lipoprotein DcrB/SciW involved in osmoprotection and C1/C6 phage infection
150	286	COG5479	M	LGFP repeat-containing protein, may be involved in cell wall binding
290	556	COG5520	M	O-Glycosyl hydrolase
133	229	COG5577	M	Spore coat protein CotF
37	38	COG5597	M	N-acetylglucosaminyl transferase
303	343	COG5622	M	Protein required for attachment to host cells
172	290	COG5632	M	N-acetylmuramoyl-L-alanine amidase CwlA