L - Replication, recombination and repair

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COG definitions	Organims	Proteins	Median Protein Length	Genes
203	2,296	267,934	391.0	179

Organism	Protein	COG	Cat	Annotation
1330	1838	COG0122	L	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase
2155	2181	COG0164	L	Ribonuclease HII
2159	2597	COG0177	L	Endonuclease III
2142	3266	COG0178	L	Excinuclease UvrABC ATPase subunit
2198	3735	COG0187	L	DNA gyrase/topoisomerase IV, subunit B
2195	3776	COG0188	L	DNA gyrase/topoisomerase IV, subunit A
2170	5188	COG0210	L	Superfamily I DNA or RNA helicase
1816	2538	COG0249	L	DNA mismatch repair ATPase MutS
2252	2740	COG0258	L	5'-3' exonuclease Xni/ExoIX (flap endonuclease)
1637	2447	COG0266	L	Formamidopyrimidine-DNA glycosylase
1165	2286	COG0270	J L	DNA-cytosine methylase Dcm or eukaryotic tRNA-C38 C5-methylase, Dcm/DNMT2/TRDMT1 family
2102	2442	COG0272	L	NAD-dependent DNA ligase
2083	2657	COG0305	L	Replicative DNA helicase
2134	2761	COG0322	L	Excinuclease UvrABC, nuclease subunit
1833	1998	COG0323	L	DNA mismatch repair ATPase MutL
1887	2296	COG0328	L	Ribonuclease HI
800	1218	COG0338	L	DNA-adenine methylase
2059	3018	COG0350	L	DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase)
2004	2005	COG0353	L	Recombinational DNA repair protein RecR
2261	3108	COG0358	L	DNA primase (bacterial type)
1902	3793	COG0389	L	Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair
1357	1925	COG0415	L	Deoxyribodipyrimidine photolyase
536	728	COG0417	L	DNA polymerase B elongation subunit
1474	2198	COG0419	L	DNA repair exonuclease SbcCD ATPase subunit
1563	2139	COG0420	L	DNA repair exonuclease SbcCD nuclease subunit
1401	2413	COG0433	L	Crenarchaeal DNA import helicase CedB/HerA or a related bacterial ATPase
2237	2555	COG0468	L	RecA/RadA recombinase
1118	1319	COG0470	L	DNA polymerase III, delta prime subunit
1969	7382	COG0488	J L	ABC cassette proteins with duplicated ATPase domains, Uup/ABCF family
1523	1736	COG0496	L	Broad specificity polyphosphatase and 5'/3'-nucleotidase SurE
1917	1993	COG0497	L	DNA repair ATPase RecN
1576	2609	COG0507	L	ATPase/5'-3' helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V)
2060	6520	COG0513	L	Superfamily II DNA and RNA helicase
1634	2801	COG0514	L	Superfamily II DNA helicase RecQ
2043	2043	COG0536	L D	GTPase involved in cell partioning and DNA repair
2235	3258	COG0550	L	DNA topoisomerase IA
1162	1682	COG0551	L	DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains
1508	3151	COG0553	K L	Superfamily II DNA or RNA helicase, SNF2 family
2125	2147	COG0556	L	Excinuclease UvrABC helicase subunit UvrB
916	2205	COG0582	L X	Integrase/recombinase, includes phage integrase
2079	3200	COG0587	L	DNA polymerase III, alpha subunit
2275	2597	COG0592	L	DNA polymerase III sliding clamp (beta) subunit, PCNA homolog
2044	3076	COG0593	L	Chromosomal replication initiation ATPase DnaA
1955	2204	COG0608	L	ssDNA-specific exonuclease RecJ, DHH superfamily, may be involved in archaeal DNA replication intiation
2077	3799	COG0629	L	Single-stranded DNA-binding protein
2043	2049	COG0632	L	Holliday junction resolvasome RuvABC DNA-binding subunit
1051	1163	COG0648	L	Endonuclease IV
1289	1331	COG0692	L	Uracil-DNA glycosylase
296	449	COG0699	L	Replication fork clamp-binding protein CrfC (dynamin-like GTPase family)
1868	2906	COG0708	L	Exonuclease III
2000	2350	COG0749	L	DNA polymerase I, 3'-5' exonuclease and polymerase domains
1982	2277	COG0758	L	Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake
1807	1829	COG0792	L	Predicted endonuclease distantly related to archaeal Holliday junction resolvase, YraN/UPF0102 family
1983	2077	COG0816	J K L	YqgF/RuvX protein, pre-16S rRNA maturation RNase/Holliday junction resolvase/anti-termination factor
1827	1951	COG0817	L	Holliday junction resolvasome RuvABC endonuclease subunit RuvC
239	256	COG0827	L	Adenine-specific DNA N6-methylase
1648	3488	COG0847	L	DNA polymerase III, epsilon subunit or related 3'-5' exonuclease
1160	2479	COG0863	L V	DNA modification adenine methylase
201	205	COG1039	L	Ribonuclease HIII
1537	1642	COG1058	L	ADP-ribose pyrophosphatase domain of DNA damage- and competence-inducible protein CinA
84	85	COG1059	L V	Thermostable 8-oxoguanine DNA glycosylase
1468	2940	COG1061	K L	Superfamily II DNA or RNA helicase
1878	1944	COG1066	L	DNA repair protein RadA/Sms, contains AAA+ ATPase domain
1840	2151	COG1074	L	3'-5' helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V)
118	178	COG1107	L	Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain
78	103	COG1110	L	Reverse gyrase
229	250	COG1111	L	ERCC4-related helicase
972	1494	COG1112	L	Superfamily I DNA and/or RNA helicase
1798	1837	COG1194	L	Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs
1699	1774	COG1195	L	Recombinational DNA repair ATPase RecF
1975	2011	COG1197	K L	Transcription-repair coupling factor (superfamily II helicase)
2030	2052	COG1198	L	Primosomal protein N' (replication factor Y) - superfamily II helicase
1494	2041	COG1199	L	Rad3-related DNA helicase DinG
1912	2011	COG1200	L	RecG-like helicase
970	1266	COG1201	L	Lhr-like helicase
110	178	COG1202	L	Superfamily II helicase, archaea-specific
456	596	COG1204	L	Replicative superfamily II helicase
766	1066	COG1205	L	ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain
193	270	COG1241	L	DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family
581	721	COG1273	L	Non-homologous end joining protein Ku, dsDNA break repair
162	163	COG1311	L	Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B
1381	1412	COG1322	L	DNA anti-recombination protein (rearrangement mutator) RmuC
487	494	COG1330	L	Scaffold subunit RecC of the DNA repair enzyme RecBCD (exonuclease V)
1708	1730	COG1354	L	Chromatin segregation and condensation protein Rec8/ScpA/Scc1, kleisin family
406	718	COG1372	L X	Intein/homing endonuclease, contains LAGLIDADG-like domain
1955	1958	COG1381	L	Recombinational DNA repair protein RecO (RecF pathway)
208	218	COG1389	L	DNA topoisomerase VI, subunit B
115	115	COG1423	L	ATP-dependent RNA circularization protein, DNA/RNA ligase (PAB1020) family
2057	2091	COG1466	L	DNA polymerase III, delta subunit
184	213	COG1467	L	Eukaryotic-type DNA primase, small subunit
312	1002	COG1474	L	Cdc6-related protein, AAA superfamily ATPase
1027	2565	COG1484	L	DNA replication protein DnaC
566	582	COG1515	L	Deoxyinosine 3'-endonuclease (endonuclease V)
1084	1823	COG1525	L	Endonuclease YncB, thermonuclease family
1143	1470	COG1533	L	DNA thymine dimer repair photolyase
1527	1932	COG1555	L	DNA uptake protein ComE or related DNA-binding protein
1855	1885	COG1570	L	Exonuclease VII, large subunit
1604	2759	COG1573	L	Uracil-DNA glycosylase
170	183	COG1591	L	Holliday junction resolvase Hjc, archaeal type
185	467	COG1599	L	ssDNA-binding replication factor A, large subunit
182	200	COG1602	L	Archaeal DNA repair protein NreA
67	75	COG1630	L	ssDNA and dsDNA 5'-3' nuclease NurA, repair of double-stranded DNA breaks
522	656	COG1637	L	Endonuclease NucS, RecB family
220	227	COG1697	L	DNA topoisomerase VI, subunit A
167	186	COG1711	L	DNA replication initiation complex subunit, GINS family
1731	1737	COG1722	L	Exonuclease VII small subunit
304	431	COG1743	L	Adenine-specific DNA methylase, contains a Zn-ribbon domain
1134	2004	COG1793	L	ATP-dependent DNA ligase
565	621	COG1796	L	DNA polymerase/3'-5' exonuclease PolX
130	131	COG1860	L F	Predicted metal-binding protein, contains two cysteine clusters, UPF0179 family
160	161	COG1933	L	Archaeal DNA polymerase II, large subunit
220	265	COG1948	L	ERCC4-type crossover junction endonuclease
1426	4834	COG1961	L	Site-specific DNA recombinase SpoIVCA/DNA invertase PinE
1651	2264	COG2003	L	DNA repair protein RadC, contains a helix-hairpin-helix DNA-binding motif
725	732	COG2094	L	3-methyladenine DNA glycosylase Mpg
1128	1501	COG2135	L	ssDNA abasic site-binding protein YedK/HMCES, SRAP family
830	1006	COG2169	L	Methylphosphotriester-DNA--protein-cysteine methyltransferase, contains Zn-binding and AraC-type DNA-binding domains
996	1453	COG2176	L	DNA polymerase III, alpha subunit (gram-positive type)
675	958	COG2189	L	Adenine specific DNA methylase Mod
188	197	COG2219	L	Eukaryotic-type DNA primase, large subunit
298	301	COG2231	L	3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily
2035	2087	COG2255	L	Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB
1958	2084	COG2256	L	Replication-associated recombination protein RarA (DNA-dependent ATPase)
560	561	COG2354	L	Membrane protein MutK/YedI, may be involved in DNA repair
387	554	COG2356	L	Endonuclease I
149	177	COG2406	L	Ferritin-like DNA-binding protein, DPS (DNA Protection under Starvation) family
2099	3271	COG2812	L	DNA polymerase III, gamma/tau subunits
1261	1460	COG2818	L	3-methyladenine DNA glycosylase Tag
1138	1814	COG2827	L	Predicted endonuclease, GIY-YIG superfamily
853	958	COG2840	J L	Stalled ribosome-rescuing mRNA endonuclease or DNA-nicking endonuclease, Smr domain
826	1775	COG2852	L	Very-short-patch-repair endonuclease
1051	1520	COG2887	L	RecB family exonuclease
388	395	COG2925	L	Exonuclease I (degrades ssDNA)
766	767	COG2927	L	DNA polymerase III, chi subunit
83	136	COG2946	L	DNA relaxase NicK
288	288	COG2965	L	Primosomal replication protein N
459	509	COG2974	L	DNA recombination-dependent growth factor RdgC
990	1008	COG3022	L	DNA-binding protein YaaA associated with the oxidative stress response
752	752	COG3024	L	Endogenous inhibitor of DNA gyrase, YacG/DUF329 family
109	109	COG3050	L	DNA polymerase III, psi subunit
131	131	COG3057	L	Negative regulator of replication initiation SeqA
201	203	COG3066	L	DNA mismatch repair protein MutH
223	233	COG3081	L	dsDNA-binding nucleoid-associated protein YejK/NdpA
96	97	COG3120	L	Macrodomain Ter protein organizer, MatP/YcbG family
127	131	COG3141	L	dsDNA-binding SOS-regulon protein YebG, induction by DNA damage requires cAMP
783	919	COG3145	L	Alkylated DNA repair dioxygenase AlkB
533	614	COG3214	L	DNA glycosylase YcaQ, repair of DNA interstrand crosslinks
589	951	COG3285	L	DNA ligase D, polymerase domain, archaeal/eukaryal DNA primase (AEP) superfamily
196	199	COG3298	L	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB
125	229	COG3390	L	Replication protein A (RPA) family protein
171	199	COG3392	L	Adenine-specific DNA methylase
413	556	COG3449	L	DNA gyrase inhibitor GyrI/SbmC
424	434	COG3569	L	DNA topoisomerase IB
829	1152	COG3593	L	Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains
437	619	COG3598	L	RecA-family ATPase
188	199	COG3611	L	Replication initiation and membrane attachment protein DnaB
703	729	COG3663	L	G:T/U-mismatch repair DNA glycosylase
148	170	COG3723	L	Recombinational DNA repair protein RecT
512	576	COG3727	L	G:T-mismatch repair DNA endonuclease Vsr, very short patch repair protein
413	769	COG3743	L	Predicted 5' DNA nuclease, flap endonuclease-1-like, helix-3-turn-helix (H3TH) domain
9	11	COG3780	L	DNA endonuclease related to intein-encoded endonucleases
161	175	COG3826	L	Predicted oxygenase catalyzing oxidative demethylation of damaged DNA, 2OG-oxygenase superfamily
856	920	COG3857	L	ATP-dependent helicase/DNAse subunit B
356	395	COG3886	L	HKD family nuclease
571	576	COG3893	L	Inactivated superfamily I helicase
109	109	COG3923	L	Primosomal replication protein N''
356	486	COG3935	L	DNA replication protein DnaD
242	280	COG3972	L	Superfamily I DNA and RNA helicases
481	809	COG3973	L	DNA helicase IV
41	42	COG4047	L	N-glycosylase/DNA lyase (8-oxoguanine DNA glycosylase)
188	194	COG4098	L	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein)
151	151	COG4199	L	ssDNA-specific exonuclease RecJ
405	645	COG4227	L	Antirestriction protein ArdC
206	238	COG4294	L	UV DNA damage repair endonuclease
307	330	COG4335	L	3-methylpurine DNA glycosylase AlkC
163	169	COG4389	L	Site-specific recombinase
63	76	COG4396	L X	Mu-like prophage host-nuclease inhibitor protein Gam can participate in DNA repair
194	196	COG4467	L	Regulator of replication initiation timing YabA
450	519	COG4544	L	Translesion DNA synthesis-associated protein ImuA
285	349	COG4570	L	Holliday junction resolvase RusA (prophage-encoded endonuclease)
689	930	COG4581	L	Superfamily II RNA helicase
178	263	COG4646	L	Adenine-specific DNA methylase, N12 class
43	55	COG4688	L	Predicted site-specific recombinase/integrase
63	85	COG4712	L	Predicted ssDNA annealing protein, contains HHH motif, Rad42/Rad22/RecT/erf family
505	570	COG4717	L	Predicted ATPase SbcE/YhaN involved in DNA double-strand break repair, contains AAA domain
93	131	COG4817	L	DNA-binding ferritin-like protein (Dps family)
731	923	COG4912	L	3-methyladenine DNA glycosylase AlkD
897	1424	COG4973	L	Site-specific recombinase XerC
2212	15090	COG4974	L	Site-specific tyrosine recombinase XerD
22	22	COG4998	L	Predicted endonuclease, RecB family
29	33	COG5055	L	Recombinational DNA repair protein (RAD52 pathway)
2	2	COG5056	L	O-acyltransferase, MBOAT family
4	4	COG5235	L	Single-stranded DNA-binding replication protein A (RPA), 30 kD subunit
351	2001	COG5464	L	Recombination-promoting DNA endonuclease RpnC/YadD
67	133	COG5851	L D	Stage 0 sporulation inhibitor Sda, checkpoint for initiation of sporulation and replication
12	12	COG6115	L	Replication initiator protein WhiP, Cdt1-like family
7	7	COG6116	L	Eukaryotic-type DNA primase, noncatalytic subunit PriX
20	26	COG6117	L	Eukaryotic-type DNA primase, small subunit homolog
21	21	COG6118	L	Eukaryotic-type DNA primase, LigD-like domain
5	5	COG6119	L	DNA replication initiation complex subunit, GINS23-like (arCOG05026) family
4	4	COG6123	L	Protein TIP, PCNA inhibitor
21	21	COG6124	L	DNA polymerase PolB1 small subunit PBP1
23	23	COG6125	L	DNA polymerase PolB1 small subunit PBP2, contains HTH domain