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COG definitions	Organims	Proteins	Median Protein Length	Genes
224	2,296	480,247	231.0	191

Organism	Protein	COG	Cat	Annotation
2257	2415	COG0085	K	DNA-directed RNA polymerase, beta subunit/140 kD subunit
2251	2527	COG0086	K	DNA-directed RNA polymerase, beta' subunit/160 kD subunit
2251	2325	COG0195	K	Transcription antitermination factor NusA, contains S1 and KH domains
2260	2378	COG0202	K	DNA-directed RNA polymerase, alpha subunit/40 kD subunit
2052	2219	COG0217	J K	Transcriptional and/or translational regulatory protein YebC/TACO1
2270	2871	COG0250	K	Transcription termination/antitermination protein NusG
869	1153	COG0271	K T	DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation
1992	3179	COG0317	K T	(p)ppGpp synthase/hydrolase, HD superfamily
628	807	COG0454	K R	N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2)
1508	3151	COG0553	K L	Superfamily II DNA or RNA helicase, SNF2 family
1844	2257	COG0557	K	Exoribonuclease R
2087	5011	COG0568	K	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)
2069	2170	COG0571	K	dsRNA-specific ribonuclease
1902	34560	COG0583	K	DNA-binding transcriptional regulator, LysR family
2070	11390	COG0640	K	DNA-binding transcriptional regulator, ArsR family
1820	2104	COG0718	K	DNA-binding nucleoid-associated protein YbaB/EfbC
2122	31346	COG0745	K T	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain
2198	2554	COG0750	K O	Membrane-associated protease RseP, regulator of RpoE activity
2078	2922	COG0781	K	Transcription antitermination protein NusB
1986	3498	COG0782	K	Transcription elongation factor, GreA/GreB family
1907	9997	COG0789	K	DNA-binding transcriptional regulator, MerR family
1983	2077	COG0816	J K L	YqgF/RuvX protein, pre-16S rRNA maturation RNase/Holliday junction resolvase/anti-termination factor
661	966	COG0864	K	Metal-responsive transcriptional regulator, contains CopG/Arc/MetJ DNA-binding domain
1468	2940	COG1061	K L	Superfamily II DNA or RNA helicase
192	192	COG1095	K	DNA-directed RNA polymerase, subunit E'/Rpb7
1819	1930	COG1158	K	Transcription termination factor Rho
1484	4775	COG1167	K E	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain
1149	2114	COG1191	K	DNA-directed RNA polymerase specialized sigma subunit
1975	2011	COG1197	K L	Transcription-repair coupling factor (superfamily II helicase)
105	113	COG1221	K T	Transcriptional regulators containing sigma54-interacting ATPase domain
42	42	COG1224	K	DNA helicase TIP49, TBP-interacting protein
1871	5933	COG1278	K	Cold shock protein, CspA family
232	242	COG1308	K	Transcription factor homologous to NACalpha-BTF3
2050	32570	COG1309	K	DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA
61	70	COG1318	K	Predicted transcriptional regulator
1284	2110	COG1321	K	Mn-dependent transcriptional regulator MntR, DtxR family
1671	1711	COG1327	K	Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains
838	925	COG1329	K	RNA polymerase-interacting regulator, CarD/CdnL/TRCF family
1255	4014	COG1349	K G	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family
84	96	COG1356	K	Transcriptional regulator
404	1132	COG1378	K	Sugar-specific transcriptional regulator TrmB
1638	1752	COG1386	K	Chromosome segregation and condensation protein ScpB
200	206	COG1395	K	Predicted transcriptional regulator
1935	14937	COG1396	K	Transcriptional regulator, contains XRE-family HTH domain
192	896	COG1405	K	Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB
1220	6217	COG1414	K	DNA-binding transcriptional regulator, IclR family
1418	1425	COG1420	K	Transcriptional regulator of heat shock response
729	820	COG1438	K	Arginine repressor
189	191	COG1460	K	DNA-directed RNA polymerase, subunit F
1296	3281	COG1476	K	DNA-binding transcriptional regulator, XRE-family HTH domain
647	649	COG1481	K	DNA-binding transcriptional regulator WhiA, involved in cell division
122	127	COG1497	K	Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain
1360	1466	COG1508	K	DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog
586	806	COG1510	K	DNA-binding transcriptional regulator GbsR, MarR family
1787	9587	COG1522	K	DNA-binding transcriptional regulator, Lrp family
115	183	COG1581	K B	DNA/RNA-binding protein AlbA/Sso10b
220	367	COG1594	K	DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS
1868	22489	COG1595	K	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family
1414	13444	COG1609	K	DNA-binding transcriptional regulator, LacI/PurR family
191	191	COG1644	K	DNA-directed RNA polymerase, subunit N (RpoN/RPB10)
837	878	COG1654	K	Biotin operon repressor
170	173	COG1675	K	Transcription initiation factor IIE, alpha subunit
1151	1179	COG1678	K	Putative transcriptional regulator, AlgH/UPF0301 family
66	93	COG1693	K	Repressor of nif and glnA expression
1415	5186	COG1695	K	DNA-binding transcriptional regulator, PadR family
183	186	COG1709	K	Predicted transcriptional regulator,contains XRE-type HTH domain
950	2077	COG1725	K	DNA-binding transcriptional regulator YhcF, GntR family
1492	4958	COG1733	K	DNA-binding transcriptional regulator, HxlR family
1588	2659	COG1734	K	RNA polymerase-binding transcription factor DksA
1003	3101	COG1737	K	DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains
1799	1809	COG1758	K	DNA-directed RNA polymerase, subunit K/omega
190	191	COG1761	K	DNA-directed RNA polymerase, subunit L/RPAC2
302	744	COG1777	K	Predicted transcriptional regulator, ArsR family
393	453	COG1782	K	Transcription-terminating endoRNase FttA, contains metallo-beta-lactamase and KH domains
1273	7165	COG1802	K	DNA-binding transcriptional regulator, GntR family
256	284	COG1827	K H	Transcriptional regulator of NAD metabolism, contains HTH and 3H domains
2004	16294	COG1846	K	DNA-binding transcriptional regulator, MarR family
1096	1746	COG1937	K	DNA-binding transcriptional regulator, FrmR family
1740	6444	COG1940	K G	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain
230	283	COG1954	K	Glycerol-3-phosphate responsive antiterminator (mRNA-binding)
187	321	COG1958	K	Small nuclear ribonucleoprotein (snRNP) homolog
1790	4402	COG1959	K	DNA-binding transcriptional regulator, IscR family
1755	2770	COG1974	K T	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)
911	1406	COG1983	K T	Phage shock protein PspC (stress-responsive transcriptional regulator)
312	353	COG1996	K	DNA-directed RNA polymerase, subunit RPC12/RpoP, contains C4-type Zn-finger
578	1018	COG2002	K B V	DNA-binding transcriptional regulator, chromatin protein or antitoxin AbrBPrlF/Sso7c4, AbrB family
759	959	COG2005	K	DNA-binding transcriptional regulator ModE (molybdenum-dependent)
190	191	COG2012	K	DNA-directed RNA polymerase, subunit H, RpoH/RPB5
211	216	COG2093	K	RNA polymerase subunit RPABC4/transcription elongation factor Spt4
188	315	COG2101	K	TATA-box binding protein (TBP), component of TFIID and TFIIIB
1332	1351	COG2183	K	Transcriptional accessory protein Tex/SPT6
1177	4388	COG2186	K	DNA-binding transcriptional regulator, FadR family
1320	4748	COG2188	K	DNA-binding transcriptional regulator, GntR family
1861	17952	COG2197	K T	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains
1712	20627	COG2207	K	AraC-type DNA-binding domain and AraC-containing proteins
1030	3773	COG2208	K T	Phosphoserine phosphatase RsbU, regulator of sigma subunit
387	487	COG2214	K	Curved DNA-binding protein CbpA, contains a DnaJ-like domain
754	877	COG2315	K	Predicted DNA-binding protein with double-wing structural motif, MmcQ/YjbR family
650	744	COG2344	K	NADH/NAD ratio-sensing transcriptional regulator Rex
644	1007	COG2345	K	Predicted transcriptional regulator, ArsR family
1480	3723	COG2378	K	Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains
659	1233	COG2390	K	DNA-binding transcriptional regulator LsrR, DeoR family
509	1722	COG2508	K	DNA-binding transcriptional regulator, PucR/PutR family
217	317	COG2522	K	Predicted transcriptional regulator, contains HTH domain
1132	2067	COG2524	K	Predicted transcriptional regulator, contains C-terminal CBS domains
392	451	COG2732	K	Barstar, RNAse (barnase) inhibitor
410	410	COG2739	K	Predicted DNA-binding protein YlxM, UPF0122 family
649	683	COG2747	K N	Negative regulator of flagellin synthesis (anti-sigma28 factor)
397	679	COG2771	K	DNA-binding transcriptional regulator, CsgD family
855	1736	COG2865	K	Predicted transcriptional regulator, contains HTH domain
454	468	COG2901	K	DNA-binding protein Fis (factor for inversion stimulation)
618	1316	COG2909	K	ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT
668	1127	COG2944	K	DNA-binding transcriptional regulator YiaG, XRE-type HTH domain
348	465	COG2964	K	Predicted transcriptional regulator YheO, contains PAS and DNA-binding HTH domains
138	139	COG2973	K	Trp operon repressor
128	128	COG3060	K E	Transcriptional regulator MetJ (met regulon)
614	681	COG3070	K	Transcriptional regulator of competence genes, TfoX/Sxy family
131	131	COG3112	K	YacL protein, interacts with RNA polymerase and NusG, UPF0231 family
170	172	COG3160	K	Regulator of sigma D
1217	2467	COG3177	K	Fic family protein
332	766	COG3226	K	DNA-binding transcriptional regulator YbjK
1073	4040	COG3279	K T	DNA-binding response regulator, LytR/AlgR family
157	168	COG3283	K E	Transcriptional regulator TyrR of aromatic amino acids metabolism
549	945	COG3284	K	Transcriptional regulator DhaR of acetoin/glycerol metabolism
242	421	COG3289	K	Stand-alone LytTR domain, transcriptional regulator
904	1687	COG3311	K X	DNA-binding transcriptional regulator AlpA
321	445	COG3327	K	DNA-binding transcriptional regulator PaaX (phenylacetic acid degradation)
210	212	COG3343	K	DNA-directed RNA polymerase, delta subunit
198	569	COG3355	K N	Transcriptional regulator of archaellar biosynthesis and archaeal biofilm formation AfbR
143	145	COG3357	K	Predicted transcriptional regulator, contains HTH and Zn-ribbon domains
16	23	COG3373	K N	Transcriptional regulator of archaellum operon
105	132	COG3388	K	Predicted transcriptional regulator
152	389	COG3398	K	Predicted transcriptional regulator, contains two HTH domains
142	282	COG3423	K	Predicted transcriptional regulator, lambda repressor-like DNA-binding domain
797	1788	COG3604	K T	FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains
613	1176	COG3609	K	Transcriptional regulator, contains Arc/MetJ-type RHH (ribbon-helix-helix) DNA-binding domain
1155	1825	COG3620	K	Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair)
490	2002	COG3629	K	DNA-binding transcriptional regulator DnrI/AfsR/EmbR, SARP family, contains BTAD domain
816	1385	COG3655	K	DNA-binding transcriptional regulator, XRE family
820	1765	COG3682	K	Transcriptional regulator, CopY/TcrY family
852	914	COG3695	K	Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain
1244	5691	COG3706	K T	Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain
870	1501	COG3707	K T	Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains
578	994	COG3708	K	Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain
419	1172	COG3710	K	DNA-binding winged helix-turn-helix (wHTH) domain
382	1558	COG3711	K	Transcriptional antiterminator
84	93	COG3722	K	DNA-binding transcriptional regulator, MltR family
234	379	COG3801	K	Predicted DNA-binding protein, MmcQ/YjbR superfamily
291	291	COG3820	K	Cell cycle regulator TrcR, DUF1013 family
843	2941	COG3829	K T	RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains
278	429	COG3831	K	WGR domain, predicted DNA-binding domain in MolR
496	907	COG3835	K T	Sugar diacid utilization regulator CdaR
207	232	COG3877	K	Predicted DNA-binding transcriptional regulator with XRE-family HTH domain, DUF2089 family
27	28	COG3888	K	Predicted transcriptional regulator
163	195	COG3901	K	Transcriptional regulator NosR of nitric oxide reductase
266	359	COG3905	K	Predicted transcriptional regulator, contains ribbon-helix-helix (RHH_1) domain
121	236	COG3933	K	Transcriptional regulator of LevR family, contains sigma54-interacting AAA domain, PTS regulation domain (PRD), and EIIA-type domain
185	255	COG3947	K T	Two-component response regulator, SAPR family, consists of REC, wHTH and BTAD domains
39	40	COG4008	K	Predicted metal-binding transcription factor, methanogenesis marker domain 9
500	600	COG4109	K	Predicted transcriptional regulator containing CBS domains
351	507	COG4189	K	Predicted transcriptional regulator, ArsR family
193	322	COG4190	K	Predicted transcriptional regulator, contains HTH domain
115	142	COG4197	K	DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily
232	232	COG4255	K	Regulator of pathogenicity factor RpfE
340	370	COG4256	K H	RNA-binding regulator of hemin uptake HemP/HmuP
55	61	COG4344	K	Predicted transciptional regulator, contains DUF2250 domain
271	270	COG4463	K	Transcriptional regulator CtsR
256	273	COG4465	K	GTP-sensing pleiotropic transcriptional regulator CodY
120	215	COG4512	K T	Accessory gene regulator protein AgrB
123	200	COG4533	K	DNA-binding transcriptional regulator SgrR of sgrS sRNA, contains a MarR-type HTH domain and a periplasmic-type solute-binding domain
538	843	COG4565	K T	DNA-binding response regulator DpiB of citrate/malate metabolism
553	1541	COG4566	K T	DNA-binding response regulator, FixJ family, consists of REC and HTH domains
498	566	COG4567	K T	DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains
155	159	COG4568	K	Transcriptional antiterminator Rof (Rho-off)
164	183	COG4578	K	DNA-binding transcriptional regulator of glucitol operon
128	133	COG4650	K T	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain
63	95	COG4738	K	Predicted transcriptional regulator
146	678	COG4742	K N	Transcriptional regulator of archaellar expression ArnR
987	2848	COG4753	K T	Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains
131	131	COG4776	K	Exoribonuclease II
42	44	COG4800	K	Predicted transcriptional regulator with an HTH domain
91	97	COG4815	K	DNA/RNA-binding protein MepB
107	106	COG4838	K	Fur protein antagonist Fpa/YlaN, UPF0358/DUF1507 family
43	43	COG4860	K	Predicted DNA-binding transcriptional regulator, ArsR family
209	275	COG4862	K T N	Negative regulator MecA of genetic competence, sporulation and motility
55	70	COG4871	K	Metal-binding trascriptional regulator, contains Fe-S cluster and ArsR family DNA binding domain
89	94	COG4876	K	DNA-binding prophage repressor, YdaT family
324	331	COG4877	K	Arc-like DNA-binding domain
43	44	COG4888	K	Transcription elongation factor Elf1, contains Zn-ribbon domain
103	164	COG4903	K	Competence transcription factor ComK
138	149	COG4933	K	Predicted transcriptional regulator, contains an HTH and PUA-like domains
481	1073	COG4941	K	Predicted RNA polymerase sigma factor, contains C-terminal TPR domain
251	537	COG4957	K	Predicted transcriptional regulator
1204	4320	COG4977	K	Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain
16	19	COG5108	K	Mitochondrial DNA-directed RNA polymerase
188	270	COG5164	K	Transcription elongation factor SPT5
27	29	COG5190	K	TFIIF-interacting CTD phosphatase, includes NLI-interacting factor
155	204	COG5304	K	Predicted DNA binding protein, CopG/RHH family
272	323	COG5352	K	Transcription factor GcrA interacting with sigma70
106	180	COG5419	K	Hexameric transcriptional regulator RovC, contains DUF2285 domain
188	209	COG5450	K	Transcription regulator of the Arc/MetJ class, contains ribbon-helix-helix (RHH) domain
130	129	COG5503	K V	DNA-dependent RNA polymerase auxiliary subunit epsilon
192	294	COG5566	K X	Transcriptional regulator, middle operon regulator (Mor) family
35	40	COG5625	K	Predicted DNA-binding transcriptional regulator, contains HTH domain
124	133	COG5631	K	Predicted transcription regulator, contains HTH domain, MarR family
878	1551	COG5662	K	Transmembrane transcriptional regulator RsiW (anti-sigma-W factor)
51	56	COG5665	K	CCR4-NOT transcriptional regulation complex, NOT5 subunit
67	68	COG5794	K	RNA-binding protein Asl3888
238	240	COG5811	K D	Sporulation sigma factor SigE (mother cell-specific, SpoIIGB)
239	246	COG5812	K D	Sporulation sigma factor SigF (forespore-specific, SpoIIAC)
235	242	COG5813	K D	Sporulation sigma factor SigG (forespore-specific, SpoIIIG)
226	258	COG5814	K D	Sporulation sigma factor SigK (mother cell-specific, SpoIIIC/SpoIVCB)
233	233	COG5818	K D O	Stage II sporulation protein SpoIIGA (protease, processing of pro-sigma-E to active sigma-E)
229	236	COG5830	K D	Stage III sporulation protein SpoIIID, transcriptional regulator of sigma-E- and sigma-K-dependent genes
266	600	COG5845	K D	Stage V sporulation protein SpoVT, regulator of stationary/sporulation gene expression
98	191	COG5850	K D	Prespore-specific transcriptional regulator RsfA
110	110	COG5865	K D	Forespore-specific anti-sigma-G factor CsfB/Gin
41	40	COG5870	K D	Uncharacterized sporulation protein YbaK, contains DUF2521 domain (not related to E. coli deacylase YbaK, COG2606)
968	2208	COG5905	K D	Spore transcriptional regulator GerE (stand-alone HTH domain)
59	88	COG6084	K N	Regulator of haloarchaeal motility, adhesion and cell morphology
88	105	COG6095	K T	GlnL-type response regulators, contains REC and YcbB domains
15	20	COG6096	K T	Betaproteobacterial response regulator, contains REC and BetR domain
24	24	COG6136	K	Archaeal DNA-directed RNA polymerase subunit 8, Rpo8/RpbG
8	8	COG6137	K	Archaeal DNA-directed RNA polymerase subunit 13, Rpo13/RpbQ