H - Coenzyme transport and metabolism
Stats
| COG definitions |
Organims | Proteins | Median Protein Length |
Genes |
|---|---|---|---|---|
| 267 | 2,294 | 401,197 | 294.0 | 262 |
| Organism | Protein | COG | Cat | Annotation |
|---|---|---|---|---|
| 1715 | 2497 | COG0001 | H | Glutamate-1-semialdehyde aminotransferase |
| 1634 | 2474 | COG0007 | H | Uroporphyrinogen-III methylase (siroheme synthase) |
| 726 | 826 | COG0011 | H | Thiamin-binding stress-response protein YqgV, UPF0045 family |
| 1982 | 5801 | COG0028 | E H | Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme |
| 1540 | 1705 | COG0029 | H | Aspartate oxidase |
| 1098 | 1393 | COG0043 | H | 3-polyprenyl-4-hydroxybenzoate decarboxylase |
| 1934 | 2062 | COG0054 | H | 6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain) |
| 1880 | 1948 | COG0059 | E H | Ketol-acid reductoisomerase |
| 2178 | 2516 | COG0061 | H | NAD kinase |
| 984 | 1518 | COG0095 | H | Lipoate-protein ligase A |
| 1915 | 2165 | COG0108 | H | 3,4-dihydroxy-2-butanone 4-phosphate synthase |
| 1464 | 1584 | COG0109 | H I | Polyprenyltransferase (heme O synthase) |
| 2036 | 5766 | COG0111 | H | Phosphoglycerate dehydrogenase or related dehydrogenase |
| 1869 | 1915 | COG0113 | H | Delta-aminolevulinic acid dehydratase, porphobilinogen synthase |
| 2080 | 4994 | COG0115 | E H | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase |
| 1782 | 1835 | COG0117 | H | Riboflavin biosynthesis protein RibD, pyrimidine deaminase domain |
| 1194 | 1297 | COG0132 | H | Dethiobiotin synthetase |
| 2196 | 4706 | COG0142 | H | Geranylgeranyl pyrophosphate synthase |
| 1952 | 3587 | COG0147 | E H | Anthranilate/para-aminobenzoate synthases component I |
| 1676 | 3220 | COG0156 | H | 7-keto-8-aminopelargonate synthetase or related enzyme |
| 1716 | 1876 | COG0157 | H | Nicotinate-nucleotide pyrophosphorylase |
| 1441 | 2988 | COG0161 | H | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase |
| 1070 | 1164 | COG0163 | H | Flavin prenyltransferase UbiX |
| 2154 | 2424 | COG0171 | H | NH3-dependent NAD+ synthetase |
| 1567 | 3112 | COG0175 | E H | Phosphoadenylyl sulfate (PAPS) reductase/FAD synthetase or related enzyme |
| 1881 | 1920 | COG0181 | H | Porphobilinogen deaminase |
| 1653 | 3725 | COG0189 | J E H Q | Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily |
| 2156 | 2367 | COG0190 | H | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase |
| 2040 | 2238 | COG0192 | H | S-adenosylmethionine synthetase |
| 2006 | 2084 | COG0196 | H | FAD synthase |
| 1932 | 2076 | COG0212 | H | 5-formyltetrahydrofolate cyclo-ligase |
| 723 | 746 | COG0214 | H | Pyridoxal 5'-phosphate synthase subunit PdxS |
| 2212 | 2274 | COG0237 | H | Dephospho-CoA kinase |
| 1183 | 1352 | COG0259 | H | Pyridoxine/pyridoxamine 5'-phosphate oxidase |
| 1717 | 3878 | COG0262 | H | Dihydrofolate reductase |
| 1577 | 1682 | COG0276 | H | Protoheme ferro-lyase (ferrochelatase) |
| 2079 | 2246 | COG0285 | H | Folylpolyglutamate synthase/Dihydropteroate synthase |
| 1998 | 2473 | COG0294 | H | Dihydropteroate synthase |
| 780 | 823 | COG0301 | J H | Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) |
| 1516 | 1793 | COG0302 | H | GTP cyclohydrolase I |
| 1701 | 3042 | COG0303 | H | Molybdopterin Mo-transferase (molybdopterin biosynthesis) |
| 1866 | 1938 | COG0307 | H | Riboflavin synthase alpha chain |
| 674 | 682 | COG0311 | H | Pyridoxal 5'-phosphate synthase subunit PdxT (glutamine amidotransferase) |
| 1504 | 1544 | COG0314 | H | Molybdopterin synthase catalytic subunit MoaE |
| 1667 | 1692 | COG0315 | H | Molybdenum cofactor biosynthesis enzyme MoaC |
| 1711 | 1846 | COG0320 | H | Lipoate synthase |
| 1469 | 1500 | COG0321 | H | Lipoate-protein ligase B (lipoyltransferase) |
| 1942 | 2023 | COG0325 | H | Pyridoxal 5'-phosphate homeostasis protein YggS, UPF0001 family |
| 1585 | 1753 | COG0327 | H | Putative GTP cyclohydrolase 1 type 2, NIF3 family |
| 2119 | 2294 | COG0340 | H | Biotin-protein ligase |
| 1706 | 2044 | COG0351 | H | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase |
| 1733 | 2634 | COG0352 | H | Thiamine monophosphate synthase |
| 1207 | 1235 | COG0368 | H | Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase) |
| 1583 | 1672 | COG0373 | H | Glutamyl-tRNA reductase |
| 1580 | 1617 | COG0379 | H | Quinolinate synthase |
| 1722 | 2900 | COG0382 | H | 4-hydroxybenzoate polyprenyltransferase |
| 1019 | 1176 | COG0391 | G H | Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family |
| 1714 | 2807 | COG0407 | H | Uroporphyrinogen-III decarboxylase HemE |
| 959 | 977 | COG0408 | H | Coproporphyrinogen-III oxidase HemH, oxygen-dependent |
| 1723 | 1832 | COG0413 | H | Ketopantoate hydroxymethyltransferase |
| 1622 | 1653 | COG0414 | H | Panthothenate synthetase |
| 1360 | 1482 | COG0422 | H | 4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP) synthase ThiC |
| 1436 | 2495 | COG0425 | J O H | Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) |
| 1252 | 1646 | COG0432 | H | Thiamin phosphate synthase YjbQ, UPF0047 family |
| 1458 | 2888 | COG0446 | H | Coenzyme A disulfide reductase or related oxidoreductase, NAD(P)H-disulfide oxidoreductase family |
| 837 | 875 | COG0447 | H | 1,4-Dihydroxy-2-naphthoyl-CoA synthase |
| 2083 | 2328 | COG0452 | H | Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC |
| 1832 | 2779 | COG0476 | H | Molybdopterin or thiamine biosynthesis adenylyltransferase |
| 1600 | 1743 | COG0499 | H | S-adenosylhomocysteine hydrolase |
| 1451 | 1722 | COG0502 | H | Biotin synthase or related enzyme |
| 622 | 888 | COG0510 | H | Thiamine kinase or a related kinase |
| 1937 | 2515 | COG0512 | E H | Anthranilate/para-aminobenzoate synthase component II (glutamine amidotransferase) |
| 1632 | 1839 | COG0521 | H | Molybdopterin adenylyltransferase MoaB/MogA |
| 1551 | 4769 | COG0535 | D H | Radical SAM superfamily maturase, SkfB/NifB/PqqE family |
| 1349 | 2455 | COG0543 | C H | NAD(P)H-flavin reductase |
| 1606 | 4602 | COG0561 | H R | Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases |
| 2097 | 22727 | COG0596 | H R | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH/undecaprenyl monophosphate-sugar esterase UshA/YqjL |
| 1575 | 1884 | COG0602 | H | Organic radical activating enzyme, includes 7-carboxy-7-deazaguanine synthase NrdG/QueE |
| 1578 | 1602 | COG0611 | H | Thiamine monophosphate kinase |
| 1197 | 2650 | COG0619 | H | ECF-type transporter transmembrane protein EcfT |
| 1979 | 3394 | COG0635 | H | Coproporphyrinogen-III oxidase HemN (oxygen-independent) or related Fe-S oxidoreductase |
| 1361 | 6548 | COG0654 | C H | 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases |
| 1608 | 2609 | COG0661 | T H | Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family |
| 1757 | 8218 | COG0667 | H R | Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family |
| 1987 | 2025 | COG0669 | H | Phosphopantetheine adenylyltransferase |
| 1531 | 2061 | COG0720 | H | 6-pyruvoyl-tetrahydropterin synthase |
| 1562 | 1670 | COG0746 | H | Molybdopterin-guanine dinucleotide biosynthesis protein A |
| 1397 | 2000 | COG0775 | F H | Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB |
| 1836 | 2079 | COG0801 | H | 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) |
| 1804 | 2506 | COG0807 | H | GTP cyclohydrolase II |
| 587 | 766 | COG0819 | H | Aminopyrimidine aminohydrolase TenA (thiamine salvage pathway) |
| 1150 | 1196 | COG0853 | H | Aspartate 1-decarboxylase |
| 1200 | 1212 | COG0854 | H | Pyridoxine 5'-phosphate synthase PdxJ |
| 851 | 902 | COG1010 | H | Precorrin-3B methylase |
| 1903 | 5396 | COG1011 | H | FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis) |
| 150 | 168 | COG1019 | H | Phosphopantetheine adenylyltransferase |
| 1573 | 3064 | COG1052 | C H R | Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase |
| 467 | 543 | COG1056 | H | Nicotinamide mononucleotide adenylyltransferase |
| 1960 | 2061 | COG1057 | H | Nicotinate-nucleotide adenylyltransferase NadD |
| 990 | 1859 | COG1060 | H | 2-iminoacetate synthase ThiH/Menaquinone biosynthesis enzymes MqnC and MqnE |
| 642 | 831 | COG1072 | H | Pantothenate kinase |
| 1754 | 4230 | COG1120 | H P | ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component |
| 1794 | 1913 | COG1154 | H I | Deoxyxylulose-5-phosphate synthase |
| 778 | 792 | COG1165 | H | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase |
| 830 | 922 | COG1169 | H Q | Isochorismate synthase EntC |
| 980 | 1368 | COG1232 | H | Protoporphyrinogen oxidase HemY/PPOX |
| 1581 | 2362 | COG1235 | H P | Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase |
| 683 | 1048 | COG1239 | H | Mg-chelatase subunit ChlI |
| 1026 | 1191 | COG1268 | H | Biotin transporter BioY |
| 1168 | 1290 | COG1270 | H | Cobalamin biosynthesis protein CobD/CbiB |
| 1785 | 4962 | COG1335 | H R | Nicotinamidase-related amidase |
| 190 | 199 | COG1339 | H | Archaeal CTP-dependent riboflavin kinase |
| 453 | 681 | COG1348 | H P | Nitrogenase ATPase subunit NifH/coenzyme F430 biosynthesis subunit CfbC |
| 837 | 1356 | COG1402 | H | Creatinine amidohydrolase/FAPy deformylase (formamide hydrolase) |
| 60 | 61 | COG1424 | H | Pimeloyl-CoA synthetase |
| 335 | 337 | COG1427 | H | Chorismate dehydratase (menaquinone biosynthesis, futalosine pathway) |
| 657 | 995 | COG1429 | H | Cobalamin biosynthesis protein CobN, Mg-chelatase |
| 126 | 126 | COG1441 | H | O-succinylbenzoate synthase |
| 657 | 698 | COG1469 | H | GTP cyclohydrolase FolE2 |
| 1342 | 1972 | COG1477 | O H | FAD:protein FMN transferase ApbE |
| 406 | 477 | COG1478 | H | F420-0:Gamma-glutamyl ligase (F420 biosynthesis) |
| 1636 | 1787 | COG1488 | H | Nicotinic acid phosphoribosyltransferase |
| 1122 | 1198 | COG1492 | H | Cobyric acid synthase |
| 1525 | 1598 | COG1521 | H | Pantothenate kinase type III |
| 1632 | 1795 | COG1539 | H | Dihydroneopterin aldolase |
| 1194 | 2535 | COG1541 | H | Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family |
| 1958 | 2159 | COG1546 | H | Nicotinamide mononucleotide (NMN) deamidase PncC |
| 144 | 145 | COG1548 | H | Methanofuran synthetase MfnF, hydantoinase/oxoprolinase family |
| 665 | 672 | COG1564 | H | Thiamine pyrophosphokinase |
| 1088 | 1283 | COG1575 | H | 1,4-dihydroxy-2-naphthoate polyprenyltransferase |
| 1912 | 2349 | COG1587 | H | Uroporphyrinogen-III synthase |
| 1273 | 1360 | COG1612 | H | Heme A synthase |
| 166 | 168 | COG1634 | H | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase MptE (tetrahydrofolate and tetrahydromethanopterin biosynthesis) |
| 180 | 188 | COG1635 | G H | Thiazole synthase/Archaeal ribulose 1,5-bisphosphate synthetase |
| 584 | 664 | COG1641 | H | CTP-dependent cyclometallase, nickel-pincer nucleotide (NPN) cofactor biosynthesis |
| 1317 | 1460 | COG1648 | H | Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) |
| 157 | 159 | COG1701 | H | Archaeal phosphopantothenate synthetase |
| 74 | 74 | COG1731 | H | Archaeal riboflavin synthase |
| 836 | 898 | COG1763 | H | Molybdopterin-guanine dinucleotide biosynthesis protein |
| 467 | 536 | COG1767 | H | Triphosphoribosyl-dephospho-CoA synthetase |
| 1018 | 1176 | COG1797 | H | Cobyrinic acid a,c-diamide synthase |
| 191 | 207 | COG1809 | H | Phosphosulfolactate synthase, CoM biosynthesis protein A |
| 205 | 215 | COG1812 | H | Archaeal S-adenosylmethionine synthetase |
| 130 | 133 | COG1821 | H | Tyramine-glutamate ligase MfnD (methanofuran biosynthesis), ATP-grasp superfamily |
| 256 | 284 | COG1827 | K H | Transcriptional regulator of NAD metabolism, contains HTH and 3H domains |
| 168 | 175 | COG1829 | H | Archaeal pantoate kinase |
| 1251 | 2670 | COG1840 | G H | ABC-type transport systems for B6 and hexose phosphate, periplasmic component |
| 315 | 348 | COG1865 | H | Adenosylcobinamide amidohydrolase |
| 151 | 151 | COG1891 | H | 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate synthase MfnB |
| 1232 | 1941 | COG1893 | H | Ketopantoate reductase |
| 642 | 649 | COG1903 | H | Cobalt-precorrin-5B methyltransferase |
| 234 | 257 | COG1907 | H | Beta-ribofuranosylaminobenzene 5'-phosphate synthase (methanopterin biosynthesis) |
| 178 | 178 | COG1909 | H | Archaeal dephospho-CoA kinase |
| 670 | 725 | COG1912 | V H | Stereoselective (R,S)-S-adenosylmethionine hydrolase (adenosine-forming) |
| 308 | 318 | COG1920 | H | 2-phospho-L-lactate guanylyltransferase, coenzyme F420 biosynthesis enzyme, CobY/MobA/RfbA family |
| 1487 | 1548 | COG1932 | E H | Phosphoserine aminotransferase |
| 329 | 430 | COG1953 | F H | Cytosine/uracil/thiamine/allantoin permease |
| 67 | 89 | COG1962 | H | Tetrahydromethanopterin S-methyltransferase, subunit H |
| 280 | 313 | COG1964 | H I | Archaeal tetraether lipid synthase/C-terminal domain of the GTP 3',8'-cyclase MoaA, radical SAM superfamily |
| 1537 | 2208 | COG1977 | H | Molybdopterin synthase sulfur carrier subunit MoaD |
| 851 | 942 | COG1981 | H | Protoporphyrinogen oxidase HemJ (unrelated to HemG or HemY) |
| 1973 | 2531 | COG1985 | H | Pyrimidine reductase, riboflavin biosynthesis |
| 178 | 283 | COG1992 | H | Thiamin biosynthesis enzyme, contains thiamin monophosphate synthase domain |
| 1368 | 1631 | COG1995 | H | 4-hydroxy-L-threonine phosphate dehydrogenase PdxA |
| 1258 | 1286 | COG2022 | H | Thiazole synthase ThiGH, ThiG subunit (thiamin biosynthesis) |
| 1190 | 1297 | COG2038 | H | NaMN:DMB phosphoribosyltransferase |
| 468 | 503 | COG2045 | H | Phosphosulfolactate phosphohydrolase or related enzyme |
| 148 | 149 | COG2054 | H | 5-(aminomethyl)-3-furanmethanol-phosphate kinase MfnE (methanofuran biosynthesis) |
| 1058 | 1182 | COG2068 | H | CTP:molybdopterin cytidylyltransferase MocA |
| 742 | 825 | COG2073 | H | Cobalt-precorrin 5A hydrolase |
| 854 | 952 | COG2082 | H | Precorrin-8X methylmutase CbiC/CobH |
| 1046 | 1139 | COG2087 | H | Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase |
| 977 | 1221 | COG2091 | H | Phosphopantetheinyl transferase |
| 1305 | 1412 | COG2096 | H | Cob(II)alamin adenosyltransferase |
| 122 | 123 | COG2098 | H | 7,8-dihydroneopterin aldolase MptD (tetrahydrofolate and tetrahydromethanopterin biosynthesis) |
| 664 | 689 | COG2099 | H | Precorrin-6x reductase |
| 1395 | 1531 | COG2104 | J H | Sulfur carrier protein ThiS/TtuB (thiamine biosynthesis, tRNA 2-thiouridylation) |
| 313 | 323 | COG2107 | H | 1,4-dihydroxy-6-naphtoate synthase (menaquinone biosynthesis, futalosine pathway) |
| 1119 | 1342 | COG2109 | H | ATP:corrinoid adenosyltransferase |
| 874 | 1183 | COG2138 | H | Sirohydrochlorin ferrochelatase |
| 1245 | 8540 | COG2141 | H R | Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase) |
| 680 | 708 | COG2145 | H | Hydroxyethylthiazole kinase, sugar kinase family |
| 473 | 557 | COG2149 | H | Membrane protein YidH involved in molybdoenzyme production, DUF202 family |
| 1229 | 1411 | COG2154 | H | Pterin-4a-carbinolamine dehydratase |
| 2214 | 19817 | COG2226 | J H | Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9 |
| 1954 | 8415 | COG2227 | H | 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase |
| 716 | 803 | COG2236 | H | Hypoxanthine phosphoribosyltransferase |
| 542 | 596 | COG2240 | H | Pyridoxal/pyridoxine/pyridoxamine kinase |
| 877 | 916 | COG2241 | H | Precorrin-6Y C5,15-methylase subunit CbiE |
| 974 | 1243 | COG2242 | H | Precorrin-6Y C5,15-methylase subunit CbiT |
| 848 | 1050 | COG2243 | H | Precorrin-2 methylase |
| 199 | 205 | COG2266 | H | GTP:adenosylcobinamide-phosphate guanylyltransferase |
| 1038 | 1765 | COG2329 | H | Heme-degrading monooxygenase HmoA and related ABM domain proteins |
| 233 | 252 | COG2503 | H | Secreted acid phosphatase/5'-nucleotidase, lipoprotein e(P4) family |
| 613 | 742 | COG2510 | H | Riboflavin transporter RibN, EamA domain |
| 372 | 1664 | COG2710 | H P | Nitrogenase Mo-Fe protein NifD/coenzyme F430 biosynthesis subunit CfbD |
| 858 | 897 | COG2875 | H | Precorrin-4 methylase |
| 1689 | 1926 | COG2896 | H | GTP 3',8-cyclase (molybdenum cofactor biosynthesis protein MoaA) |
| 421 | 439 | COG2918 | H | Gamma-glutamylcysteine synthetase |
| 384 | 410 | COG2941 | H | Demethoxyubiquinone hydroxylase, CLK1/Coq7/Cat5 family (ubiquinone biosynthesis) |
| 710 | 729 | COG2960 | H | Ubiquinone biosynthesis accessory factor UbiK |
| 326 | 450 | COG2978 | H | p-Aminobenzoyl-glutamate transporter AbgT |
| 300 | 304 | COG3154 | H | Ubiquinone biosynthesis accessory factor UbiT, lipid carrier SCP2 domain |
| 546 | 555 | COG3161 | H | 4-hydroxybenzoate synthetase (chorismate-pyruvate lyase) |
| 456 | 462 | COG3165 | H | Ubiquinone biosynthesis protein UbiJ, contains SCP2 domain |
| 422 | 469 | COG3172 | H | Nicotinamide riboside kinase |
| 645 | 748 | COG3201 | H | Nicotinamide riboside transporter PnuC |
| 295 | 360 | COG3236 | V H | N-glycosidase YbiA/RibX (riboflavin biosynthesis, damage control), NADAR superfamily |
| 210 | 215 | COG3252 | H | Methenyltetrahydromethanopterin cyclohydrolase |
| 513 | 526 | COG3253 | H P | Coproheme decarboxylase/chlorite dismutase |
| 378 | 380 | COG3442 | M H | Glutaminase/glutamine amidotransferase domain of CobB, CobQ, and lipid II isoglutaminyl synthase |
| 97 | 98 | COG3445 | H | Autonomous glycyl radical cofactor GrcA |
| 469 | 495 | COG3572 | H | Gamma-glutamylcysteine synthetase |
| 675 | 906 | COG3585 | H | Molybdopterin-binding protein MopI |
| 346 | 369 | COG3601 | H | Riboflavin transporter FmnP/RibU |
| 159 | 172 | COG3697 | H I | Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) |
| 118 | 127 | COG3721 | H P | Heme degradation regulator ChuX/HutX |
| 233 | 234 | COG3840 | H | ABC-type thiamine transport system, ATPase component ThiQ |
| 248 | 259 | COG3859 | H | Thiamine transporter ThiT |
| 181 | 242 | COG3862 | H | Molybdopterin oxidoreductase Fe4S4 domain, DUF1667 family |
| 245 | 280 | COG3961 | G H R | TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase |
| 14 | 14 | COG4016 | H | Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein HcgF, CinA family |
| 13 | 13 | COG4017 | H | Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein, methyltransferase HcgC |
| 14 | 14 | COG4018 | H | Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein, fibrillarin family |
| 13 | 13 | COG4019 | H | Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein HcgB, guanylyltransferase |
| 173 | 200 | COG4032 | H | Sulfopyruvate decarboxylase, TPP-binding subunit (coenzyme M biosynthesis) |
| 45 | 56 | COG4054 | H | Methyl coenzyme M reductase, beta subunit |
| 44 | 55 | COG4055 | H | Methyl coenzyme M reductase, subunit D |
| 45 | 46 | COG4056 | H | Methyl coenzyme M reductase, subunit C |
| 45 | 57 | COG4057 | H | Methyl coenzyme M reductase, gamma subunit |
| 45 | 59 | COG4058 | H | Methyl coenzyme M reductase, alpha subunit |
| 36 | 36 | COG4059 | H | Tetrahydromethanopterin S-methyltransferase, subunit E |
| 35 | 35 | COG4060 | H | Tetrahydromethanopterin S-methyltransferase, subunit D |
| 36 | 36 | COG4061 | H | Tetrahydromethanopterin S-methyltransferase, subunit C |
| 36 | 36 | COG4062 | H | Tetrahydromethanopterin S-methyltransferase, subunit B |
| 63 | 89 | COG4063 | H | Tetrahydromethanopterin S-methyltransferase, subunit A |
| 25 | 25 | COG4064 | H | Tetrahydromethanopterin S-methyltransferase, subunit G |
| 362 | 419 | COG4094 | H P | Zeta-carotene isomerase/dentrification protein, Z-ISO/NnrU family |
| 546 | 719 | COG4111 | H | ATP-responsive regulator of NAD biosynthesis |
| 74 | 76 | COG4138 | H | ABC-type cobalamin transport system, ATPase component BtuD |
| 98 | 101 | COG4139 | H | ABC-type cobalamin transport system, permease component BtuC |
| 459 | 477 | COG4143 | H | ABC-type thiamine transport system, periplasmic component TbpA |
| 261 | 283 | COG4145 | H | Na+/panthothenate symporter |
| 980 | 3951 | COG4206 | H | Outer membrane cobalamin receptor protein BtuB |
| 30 | 30 | COG4218 | H | Tetrahydromethanopterin S-methyltransferase, subunit F |
| 340 | 370 | COG4256 | K H | RNA-binding regulator of hemin uptake HemP/HmuP |
| 404 | 438 | COG4547 | H | Cobalamin biosynthesis cobaltochelatase CobT subunit |
| 481 | 580 | COG4635 | H | Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain) |
| 363 | 529 | COG4720 | H | Membrane component of ECF-type riboflavin transportert |
| 229 | 258 | COG4721 | H | ABC-type thiamine/hydroxymethylpyrimidine transport system, permease component |
| 151 | 151 | COG4732 | H | Membrane component ThiW of ECF-type thiazole transporter |
| 312 | 318 | COG4769 | O H | Protein flavinylation system FAD exporter subunit EetB |
| 225 | 282 | COG4822 | H | Cobalamin biosynthesis protein CbiK, Co2+ chelatase |
| 126 | 225 | COG5031 | H | Ubiquinone biosynthesis protein Coq4 |
| 51 | 51 | COG5146 | H | Pantothenate kinase |
| 204 | 256 | COG5398 | H | Heme oxygenase |
| 557 | 767 | COG5424 | H | Pyrroloquinoline quinone (PQQ) synthase PqqC, TenA/Thi4/PqqC family |
| 247 | 289 | COG5590 | H | Ubiquinone biosynthesis protein COQ9 |
| 175 | 680 | COG5598 | H | Trimethylamine:corrinoid methyltransferase |
| 193 | 276 | COG5746 | H | Light-independent protochlorophyllide reductase subunit B, BchB (=ChlB) |
| 155 | 155 | COG5747 | H | Light-independent protochlorophyllide reductase subunit N, BchN (=ChlN) |
| 581 | 1094 | COG5748 | H | Light-dependent NADPH-protochlorophyllide oxidoreductase |
| 579 | 1406 | COG5749 | H | Chlorophyllide a oxygenase/letal leaf spot protein |
| 82 | 82 | COG5753 | H | Bacteriochlorophyllide reductase subunit BchX |
| 81 | 81 | COG5754 | H | Bacteriochlorophyllide reductase subunit BchY |
| 82 | 82 | COG5755 | H | Bacteriochlorophyllide reductase subunit BchZ |
| 131 | 184 | COG5759 | H | Mg-protoporphyrin IX monomethyl ester cyclase BchE, aerobic (=Ycf59) |