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H - Coenzyme transport and metabolism

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COG
definitions
Organims Proteins Median Protein
Length
Genes
267 2,294 401,197 294.0 262
Organism Protein COG Cat Annotation
1715 2497 COG0001 H Glutamate-1-semialdehyde aminotransferase
1634 2474 COG0007 H Uroporphyrinogen-III methylase (siroheme synthase)
726 826 COG0011 H Thiamin-binding stress-response protein YqgV, UPF0045 family
1982 5801 COG0028 E H Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme
1540 1705 COG0029 H Aspartate oxidase
1098 1393 COG0043 H 3-polyprenyl-4-hydroxybenzoate decarboxylase
1934 2062 COG0054 H 6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain)
1880 1948 COG0059 E H Ketol-acid reductoisomerase
2178 2516 COG0061 H NAD kinase
984 1518 COG0095 H Lipoate-protein ligase A
1915 2165 COG0108 H 3,4-dihydroxy-2-butanone 4-phosphate synthase
1464 1584 COG0109 H I Polyprenyltransferase (heme O synthase)
2036 5766 COG0111 H Phosphoglycerate dehydrogenase or related dehydrogenase
1869 1915 COG0113 H Delta-aminolevulinic acid dehydratase, porphobilinogen synthase
2080 4994 COG0115 E H Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase
1782 1835 COG0117 H Riboflavin biosynthesis protein RibD, pyrimidine deaminase domain
1194 1297 COG0132 H Dethiobiotin synthetase
2196 4706 COG0142 H Geranylgeranyl pyrophosphate synthase
1952 3587 COG0147 E H Anthranilate/para-aminobenzoate synthases component I
1676 3220 COG0156 H 7-keto-8-aminopelargonate synthetase or related enzyme
1716 1876 COG0157 H Nicotinate-nucleotide pyrophosphorylase
1441 2988 COG0161 H Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
1070 1164 COG0163 H Flavin prenyltransferase UbiX
2154 2424 COG0171 H NH3-dependent NAD+ synthetase
1567 3112 COG0175 E H Phosphoadenylyl sulfate (PAPS) reductase/FAD synthetase or related enzyme
1881 1920 COG0181 H Porphobilinogen deaminase
1653 3725 COG0189 J E H Q Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily
2156 2367 COG0190 H 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase
2040 2238 COG0192 H S-adenosylmethionine synthetase
2006 2084 COG0196 H FAD synthase
1932 2076 COG0212 H 5-formyltetrahydrofolate cyclo-ligase
723 746 COG0214 H Pyridoxal 5'-phosphate synthase subunit PdxS
2212 2274 COG0237 H Dephospho-CoA kinase
1183 1352 COG0259 H Pyridoxine/pyridoxamine 5'-phosphate oxidase
1717 3878 COG0262 H Dihydrofolate reductase
1577 1682 COG0276 H Protoheme ferro-lyase (ferrochelatase)
2079 2246 COG0285 H Folylpolyglutamate synthase/Dihydropteroate synthase
1998 2473 COG0294 H Dihydropteroate synthase
780 823 COG0301 J H Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis)
1516 1793 COG0302 H GTP cyclohydrolase I
1701 3042 COG0303 H Molybdopterin Mo-transferase (molybdopterin biosynthesis)
1866 1938 COG0307 H Riboflavin synthase alpha chain
674 682 COG0311 H Pyridoxal 5'-phosphate synthase subunit PdxT (glutamine amidotransferase)
1504 1544 COG0314 H Molybdopterin synthase catalytic subunit MoaE
1667 1692 COG0315 H Molybdenum cofactor biosynthesis enzyme MoaC
1711 1846 COG0320 H Lipoate synthase
1469 1500 COG0321 H Lipoate-protein ligase B (lipoyltransferase)
1942 2023 COG0325 H Pyridoxal 5'-phosphate homeostasis protein YggS, UPF0001 family
1585 1753 COG0327 H Putative GTP cyclohydrolase 1 type 2, NIF3 family
2119 2294 COG0340 H Biotin-protein ligase
1706 2044 COG0351 H Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
1733 2634 COG0352 H Thiamine monophosphate synthase
1207 1235 COG0368 H Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase)
1583 1672 COG0373 H Glutamyl-tRNA reductase
1580 1617 COG0379 H Quinolinate synthase
1722 2900 COG0382 H 4-hydroxybenzoate polyprenyltransferase
1019 1176 COG0391 G H Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family
1714 2807 COG0407 H Uroporphyrinogen-III decarboxylase HemE
959 977 COG0408 H Coproporphyrinogen-III oxidase HemH, oxygen-dependent
1723 1832 COG0413 H Ketopantoate hydroxymethyltransferase
1622 1653 COG0414 H Panthothenate synthetase
1360 1482 COG0422 H 4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP) synthase ThiC
1436 2495 COG0425 J O H Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis)
1252 1646 COG0432 H Thiamin phosphate synthase YjbQ, UPF0047 family
1458 2888 COG0446 H Coenzyme A disulfide reductase or related oxidoreductase, NAD(P)H-disulfide oxidoreductase family
837 875 COG0447 H 1,4-Dihydroxy-2-naphthoyl-CoA synthase
2083 2328 COG0452 H Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC
1832 2779 COG0476 H Molybdopterin or thiamine biosynthesis adenylyltransferase
1600 1743 COG0499 H S-adenosylhomocysteine hydrolase
1451 1722 COG0502 H Biotin synthase or related enzyme
622 888 COG0510 H Thiamine kinase or a related kinase
1937 2515 COG0512 E H Anthranilate/para-aminobenzoate synthase component II (glutamine amidotransferase)
1632 1839 COG0521 H Molybdopterin adenylyltransferase MoaB/MogA
1551 4769 COG0535 D H Radical SAM superfamily maturase, SkfB/NifB/PqqE family
1349 2455 COG0543 C H NAD(P)H-flavin reductase
1606 4602 COG0561 H R Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases
2097 22727 COG0596 H R 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH/undecaprenyl monophosphate-sugar esterase UshA/YqjL
1575 1884 COG0602 H Organic radical activating enzyme, includes 7-carboxy-7-deazaguanine synthase NrdG/QueE
1578 1602 COG0611 H Thiamine monophosphate kinase
1197 2650 COG0619 H ECF-type transporter transmembrane protein EcfT
1979 3394 COG0635 H Coproporphyrinogen-III oxidase HemN (oxygen-independent) or related Fe-S oxidoreductase
1361 6548 COG0654 C H 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
1608 2609 COG0661 T H Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family
1757 8218 COG0667 H R Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family
1987 2025 COG0669 H Phosphopantetheine adenylyltransferase
1531 2061 COG0720 H 6-pyruvoyl-tetrahydropterin synthase
1562 1670 COG0746 H Molybdopterin-guanine dinucleotide biosynthesis protein A
1397 2000 COG0775 F H Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB
1836 2079 COG0801 H 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis)
1804 2506 COG0807 H GTP cyclohydrolase II
587 766 COG0819 H Aminopyrimidine aminohydrolase TenA (thiamine salvage pathway)
1150 1196 COG0853 H Aspartate 1-decarboxylase
1200 1212 COG0854 H Pyridoxine 5'-phosphate synthase PdxJ
851 902 COG1010 H Precorrin-3B methylase
1903 5396 COG1011 H FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis)
150 168 COG1019 H Phosphopantetheine adenylyltransferase
1573 3064 COG1052 C H R Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase
467 543 COG1056 H Nicotinamide mononucleotide adenylyltransferase
1960 2061 COG1057 H Nicotinate-nucleotide adenylyltransferase NadD
990 1859 COG1060 H 2-iminoacetate synthase ThiH/Menaquinone biosynthesis enzymes MqnC and MqnE
642 831 COG1072 H Pantothenate kinase
1754 4230 COG1120 H P ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component
1794 1913 COG1154 H I Deoxyxylulose-5-phosphate synthase
778 792 COG1165 H 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
830 922 COG1169 H Q Isochorismate synthase EntC
980 1368 COG1232 H Protoporphyrinogen oxidase HemY/PPOX
1581 2362 COG1235 H P Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase
683 1048 COG1239 H Mg-chelatase subunit ChlI
1026 1191 COG1268 H Biotin transporter BioY
1168 1290 COG1270 H Cobalamin biosynthesis protein CobD/CbiB
1785 4962 COG1335 H R Nicotinamidase-related amidase
190 199 COG1339 H Archaeal CTP-dependent riboflavin kinase
453 681 COG1348 H P Nitrogenase ATPase subunit NifH/coenzyme F430 biosynthesis subunit CfbC
837 1356 COG1402 H Creatinine amidohydrolase/FAPy deformylase (formamide hydrolase)
60 61 COG1424 H Pimeloyl-CoA synthetase
335 337 COG1427 H Chorismate dehydratase (menaquinone biosynthesis, futalosine pathway)
657 995 COG1429 H Cobalamin biosynthesis protein CobN, Mg-chelatase
126 126 COG1441 H O-succinylbenzoate synthase
657 698 COG1469 H GTP cyclohydrolase FolE2
1342 1972 COG1477 O H FAD:protein FMN transferase ApbE
406 477 COG1478 H F420-0:Gamma-glutamyl ligase (F420 biosynthesis)
1636 1787 COG1488 H Nicotinic acid phosphoribosyltransferase
1122 1198 COG1492 H Cobyric acid synthase
1525 1598 COG1521 H Pantothenate kinase type III
1632 1795 COG1539 H Dihydroneopterin aldolase
1194 2535 COG1541 H Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family
1958 2159 COG1546 H Nicotinamide mononucleotide (NMN) deamidase PncC
144 145 COG1548 H Methanofuran synthetase MfnF, hydantoinase/oxoprolinase family
665 672 COG1564 H Thiamine pyrophosphokinase
1088 1283 COG1575 H 1,4-dihydroxy-2-naphthoate polyprenyltransferase
1912 2349 COG1587 H Uroporphyrinogen-III synthase
1273 1360 COG1612 H Heme A synthase
166 168 COG1634 H 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase MptE (tetrahydrofolate and tetrahydromethanopterin biosynthesis)
180 188 COG1635 G H Thiazole synthase/Archaeal ribulose 1,5-bisphosphate synthetase
584 664 COG1641 H CTP-dependent cyclometallase, nickel-pincer nucleotide (NPN) cofactor biosynthesis
1317 1460 COG1648 H Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)
157 159 COG1701 H Archaeal phosphopantothenate synthetase
74 74 COG1731 H Archaeal riboflavin synthase
836 898 COG1763 H Molybdopterin-guanine dinucleotide biosynthesis protein
467 536 COG1767 H Triphosphoribosyl-dephospho-CoA synthetase
1018 1176 COG1797 H Cobyrinic acid a,c-diamide synthase
191 207 COG1809 H Phosphosulfolactate synthase, CoM biosynthesis protein A
205 215 COG1812 H Archaeal S-adenosylmethionine synthetase
130 133 COG1821 H Tyramine-glutamate ligase MfnD (methanofuran biosynthesis), ATP-grasp superfamily
256 284 COG1827 K H Transcriptional regulator of NAD metabolism, contains HTH and 3H domains
168 175 COG1829 H Archaeal pantoate kinase
1251 2670 COG1840 G H ABC-type transport systems for B6 and hexose phosphate, periplasmic component
315 348 COG1865 H Adenosylcobinamide amidohydrolase
151 151 COG1891 H 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate synthase MfnB
1232 1941 COG1893 H Ketopantoate reductase
642 649 COG1903 H Cobalt-precorrin-5B methyltransferase
234 257 COG1907 H Beta-ribofuranosylaminobenzene 5'-phosphate synthase (methanopterin biosynthesis)
178 178 COG1909 H Archaeal dephospho-CoA kinase
670 725 COG1912 V H Stereoselective (R,S)-S-adenosylmethionine hydrolase (adenosine-forming)
308 318 COG1920 H 2-phospho-L-lactate guanylyltransferase, coenzyme F420 biosynthesis enzyme, CobY/MobA/RfbA family
1487 1548 COG1932 E H Phosphoserine aminotransferase
329 430 COG1953 F H Cytosine/uracil/thiamine/allantoin permease
67 89 COG1962 H Tetrahydromethanopterin S-methyltransferase, subunit H
280 313 COG1964 H I Archaeal tetraether lipid synthase/C-terminal domain of the GTP 3',8'-cyclase MoaA, radical SAM superfamily
1537 2208 COG1977 H Molybdopterin synthase sulfur carrier subunit MoaD
851 942 COG1981 H Protoporphyrinogen oxidase HemJ (unrelated to HemG or HemY)
1973 2531 COG1985 H Pyrimidine reductase, riboflavin biosynthesis
178 283 COG1992 H Thiamin biosynthesis enzyme, contains thiamin monophosphate synthase domain
1368 1631 COG1995 H 4-hydroxy-L-threonine phosphate dehydrogenase PdxA
1258 1286 COG2022 H Thiazole synthase ThiGH, ThiG subunit (thiamin biosynthesis)
1190 1297 COG2038 H NaMN:DMB phosphoribosyltransferase
468 503 COG2045 H Phosphosulfolactate phosphohydrolase or related enzyme
148 149 COG2054 H 5-(aminomethyl)-3-furanmethanol-phosphate kinase MfnE (methanofuran biosynthesis)
1058 1182 COG2068 H CTP:molybdopterin cytidylyltransferase MocA
742 825 COG2073 H Cobalt-precorrin 5A hydrolase
854 952 COG2082 H Precorrin-8X methylmutase CbiC/CobH
1046 1139 COG2087 H Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase
977 1221 COG2091 H Phosphopantetheinyl transferase
1305 1412 COG2096 H Cob(II)alamin adenosyltransferase
122 123 COG2098 H 7,8-dihydroneopterin aldolase MptD (tetrahydrofolate and tetrahydromethanopterin biosynthesis)
664 689 COG2099 H Precorrin-6x reductase
1395 1531 COG2104 J H Sulfur carrier protein ThiS/TtuB (thiamine biosynthesis, tRNA 2-thiouridylation)
313 323 COG2107 H 1,4-dihydroxy-6-naphtoate synthase (menaquinone biosynthesis, futalosine pathway)
1119 1342 COG2109 H ATP:corrinoid adenosyltransferase
874 1183 COG2138 H Sirohydrochlorin ferrochelatase
1245 8540 COG2141 H R Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)
680 708 COG2145 H Hydroxyethylthiazole kinase, sugar kinase family
473 557 COG2149 H Membrane protein YidH involved in molybdoenzyme production, DUF202 family
1229 1411 COG2154 H Pterin-4a-carbinolamine dehydratase
2214 19817 COG2226 J H Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9
1954 8415 COG2227 H 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase
716 803 COG2236 H Hypoxanthine phosphoribosyltransferase
542 596 COG2240 H Pyridoxal/pyridoxine/pyridoxamine kinase
877 916 COG2241 H Precorrin-6Y C5,15-methylase subunit CbiE
974 1243 COG2242 H Precorrin-6Y C5,15-methylase subunit CbiT
848 1050 COG2243 H Precorrin-2 methylase
199 205 COG2266 H GTP:adenosylcobinamide-phosphate guanylyltransferase
1038 1765 COG2329 H Heme-degrading monooxygenase HmoA and related ABM domain proteins
233 252 COG2503 H Secreted acid phosphatase/5'-nucleotidase, lipoprotein e(P4) family
613 742 COG2510 H Riboflavin transporter RibN, EamA domain
372 1664 COG2710 H P Nitrogenase Mo-Fe protein NifD/coenzyme F430 biosynthesis subunit CfbD
858 897 COG2875 H Precorrin-4 methylase
1689 1926 COG2896 H GTP 3',8-cyclase (molybdenum cofactor biosynthesis protein MoaA)
421 439 COG2918 H Gamma-glutamylcysteine synthetase
384 410 COG2941 H Demethoxyubiquinone hydroxylase, CLK1/Coq7/Cat5 family (ubiquinone biosynthesis)
710 729 COG2960 H Ubiquinone biosynthesis accessory factor UbiK
326 450 COG2978 H p-Aminobenzoyl-glutamate transporter AbgT
300 304 COG3154 H Ubiquinone biosynthesis accessory factor UbiT, lipid carrier SCP2 domain
546 555 COG3161 H 4-hydroxybenzoate synthetase (chorismate-pyruvate lyase)
456 462 COG3165 H Ubiquinone biosynthesis protein UbiJ, contains SCP2 domain
422 469 COG3172 H Nicotinamide riboside kinase
645 748 COG3201 H Nicotinamide riboside transporter PnuC
295 360 COG3236 V H N-glycosidase YbiA/RibX (riboflavin biosynthesis, damage control), NADAR superfamily
210 215 COG3252 H Methenyltetrahydromethanopterin cyclohydrolase
513 526 COG3253 H P Coproheme decarboxylase/chlorite dismutase
378 380 COG3442 M H Glutaminase/glutamine amidotransferase domain of CobB, CobQ, and lipid II isoglutaminyl synthase
97 98 COG3445 H Autonomous glycyl radical cofactor GrcA
469 495 COG3572 H Gamma-glutamylcysteine synthetase
675 906 COG3585 H Molybdopterin-binding protein MopI
346 369 COG3601 H Riboflavin transporter FmnP/RibU
159 172 COG3697 H I Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase)
118 127 COG3721 H P Heme degradation regulator ChuX/HutX
233 234 COG3840 H ABC-type thiamine transport system, ATPase component ThiQ
248 259 COG3859 H Thiamine transporter ThiT
181 242 COG3862 H Molybdopterin oxidoreductase Fe4S4 domain, DUF1667 family
245 280 COG3961 G H R TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase
14 14 COG4016 H Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein HcgF, CinA family
13 13 COG4017 H Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein, methyltransferase HcgC
14 14 COG4018 H Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein, fibrillarin family
13 13 COG4019 H Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein HcgB, guanylyltransferase
173 200 COG4032 H Sulfopyruvate decarboxylase, TPP-binding subunit (coenzyme M biosynthesis)
45 56 COG4054 H Methyl coenzyme M reductase, beta subunit
44 55 COG4055 H Methyl coenzyme M reductase, subunit D
45 46 COG4056 H Methyl coenzyme M reductase, subunit C
45 57 COG4057 H Methyl coenzyme M reductase, gamma subunit
45 59 COG4058 H Methyl coenzyme M reductase, alpha subunit
36 36 COG4059 H Tetrahydromethanopterin S-methyltransferase, subunit E
35 35 COG4060 H Tetrahydromethanopterin S-methyltransferase, subunit D
36 36 COG4061 H Tetrahydromethanopterin S-methyltransferase, subunit C
36 36 COG4062 H Tetrahydromethanopterin S-methyltransferase, subunit B
63 89 COG4063 H Tetrahydromethanopterin S-methyltransferase, subunit A
25 25 COG4064 H Tetrahydromethanopterin S-methyltransferase, subunit G
362 419 COG4094 H P Zeta-carotene isomerase/dentrification protein, Z-ISO/NnrU family
546 719 COG4111 H ATP-responsive regulator of NAD biosynthesis
74 76 COG4138 H ABC-type cobalamin transport system, ATPase component BtuD
98 101 COG4139 H ABC-type cobalamin transport system, permease component BtuC
459 477 COG4143 H ABC-type thiamine transport system, periplasmic component TbpA
261 283 COG4145 H Na+/panthothenate symporter
980 3951 COG4206 H Outer membrane cobalamin receptor protein BtuB
30 30 COG4218 H Tetrahydromethanopterin S-methyltransferase, subunit F
340 370 COG4256 K H RNA-binding regulator of hemin uptake HemP/HmuP
404 438 COG4547 H Cobalamin biosynthesis cobaltochelatase CobT subunit
481 580 COG4635 H Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain)
363 529 COG4720 H Membrane component of ECF-type riboflavin transportert
229 258 COG4721 H ABC-type thiamine/hydroxymethylpyrimidine transport system, permease component
151 151 COG4732 H Membrane component ThiW of ECF-type thiazole transporter
312 318 COG4769 O H Protein flavinylation system FAD exporter subunit EetB
225 282 COG4822 H Cobalamin biosynthesis protein CbiK, Co2+ chelatase
126 225 COG5031 H Ubiquinone biosynthesis protein Coq4
51 51 COG5146 H Pantothenate kinase
204 256 COG5398 H Heme oxygenase
557 767 COG5424 H Pyrroloquinoline quinone (PQQ) synthase PqqC, TenA/Thi4/PqqC family
247 289 COG5590 H Ubiquinone biosynthesis protein COQ9
175 680 COG5598 H Trimethylamine:corrinoid methyltransferase
193 276 COG5746 H Light-independent protochlorophyllide reductase subunit B, BchB (=ChlB)
155 155 COG5747 H Light-independent protochlorophyllide reductase subunit N, BchN (=ChlN)
581 1094 COG5748 H Light-dependent NADPH-protochlorophyllide oxidoreductase
579 1406 COG5749 H Chlorophyllide a oxygenase/letal leaf spot protein
82 82 COG5753 H Bacteriochlorophyllide reductase subunit BchX
81 81 COG5754 H Bacteriochlorophyllide reductase subunit BchY
82 82 COG5755 H Bacteriochlorophyllide reductase subunit BchZ
131 184 COG5759 H Mg-protoporphyrin IX monomethyl ester cyclase BchE, aerobic (=Ycf59)