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Given to prevent the harmful effects of methotrexate (a cancer medicine) in patients with bone cancer (osteosarcoma). Also given to patients who receive too much methotrexate for other conditions. Also used in combination with 5-fluorouracil (Adrucil®) to relieve and prevent symptoms of advanced metastatic (cancer that has already spread) cancer of the colon and rectum. This medicine acts in the body like folic acid (vitamin B9).

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