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Edoxaban (trade name: Lixiana) has been approved in Germany since June 2015 for the treatment of deep vein thrombosis or pulmonary (lung) embolism in adults. It can also be used for the prevention of further thromboses or pulmonary embolisms.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: March 10, 2016

Deep vein thrombosis is a severe and life‐threatening disease caused by the formation of a blood clot in the deep veins, usually in the legs. The conventional treatment consists of injections of the anticoagulant heparins for five to seven days, followed by long‐term therapy with oral anticoagulants (vitamin K antagonists, e.g. warfarin). However, the high risk of bleeding and need for frequent laboratory control are important limitations to conventional therapy.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: December 2, 2017

People with advanced kidney disease frequently develop heart disease, which is the most common cause of deaths in these people. An increased level of the amino acid (homocysteine) in the blood is a risk factor for heart disease in people with advanced kidney disease. Therapies that reduce homocysteine levels (e.g. folic acid, vitamins B6 and B12) are often used, but the benefits and harms of their use are unclear. We aimed to assess the benefits and harms of homocysteine‐lowering therapies in people with advanced kidney disease who were on dialysis.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: May 31, 2016

An arteriovenous access consists of a direct surgical connection between an artery and a vein in the arm (fistula) or a plastic conduit connecting an artery and a vein (graft). If these forms of access become dysfunctional the delivery of dialysis therapy becomes suboptimal. The most common cause of access dysfunction is the development of a restriction or conduit narrowing called 'stenosis'. Because early correction of stenosis is considered critical to maintain the patency (openness) of the access and prolong its use, guidelines recommend regular surveillance of the access (i.e. screening based on diagnostic tests) in addition to or instead of a physical exam (clinical monitoring) to identify and treat early lesions.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: January 7, 2016

People with advanced kidney disease (end‐stage renal disease) need dialysis to perform kidney functions. In haemodialysis, blood is filtered through a machine. To allow a large enough passage for blood to flow between the person and the machine, an artery and a vein can be surgically joined (to form an arteriovenous fistula) or an artificial graft (a substitute for a vein) is used to join the artery to the vein. These access points might last for years but can become blocked or infected. This review investigates if additional medical therapy can keep these dialysis access points functioning.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: July 16, 2015

Venous thromboembolism (VTE) is a condition in which people develop blood clots in their veins. It includes deep vein thrombosis (DVT) and the potentially fatal pulmonary embolism (PE). VTE occurs in more than 10% of patients in hospital and is the third most frequent cause of death among them. Therefore, effective prevention is necessary for people who are at high risk of VTE. The standard method of prevention involves use of an anticoagulant, for example, low molecular weight heparin (LMWH) or warfarin, among orthopaedic patients. In recent years, another type of anticoagulant, pentasaccharide, has shown good anticoagulative effect in clinical trials. Three types of pentasaccharides are available, namely, short‐acting fondaparinux, long‐acting idraparinux and idrabiotaparinux.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: October 31, 2016

Expert-reviewed information summary about the treatment of lymphedema, a condition in which lymph fluid builds up in tissues and causes swelling.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: May 29, 2015

Since early 2011, the added benefit of most medications containing new active ingredients must be assessed as soon as they enter the market in Germany. The most important results of the IQWiG reviews are summarized here.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: November 30, 2017

This is an update of an existing Cochrane review, the last version was published in 2012.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: May 9, 2015

Scoliosis is a curving of the spine beyond that which is normal. Surgery may be needed to correct scoliosis and is often carried out when the child is young. Substantial bleeding may occur during surgery and can lead to serious complications, such as multiple organ failure. Many methods are used to reduce blood loss, including drugs that modify clotting pathways in the body. Medications known as antifibrinolytic drugs can reduce bleeding by preventing the breakdown of a blood clot. This review is an update of a review published in 2008, which looked at how well these drugs work, and how safe they are.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: September 19, 2016

Systematic Reviews in PubMed

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