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Thrombophilia testing for the prevention of recurrent venous thromboembolism

Thrombophilia is the term used to describe an hereditary or acquired predisposition to thromboembolism (the formation of a venous clot), which manifests itself as either deep vein thrombosis (DVT) or pulmonary embolism (PE). The presence of thrombophilia can be tested and many people with venous thrombosis or pulmonary embolism nowadays have their blood tested for a deficiency in natural anticoagulants such as antithrombin, protein C, or protein S. However, the benefits of these costly tests are uncertain. The most important benefit would be a reduction in the risk of developing a new venous clot by taking preventative measures. To date no high quality trials have assessed this issue.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Heparin for treatment of the neonate with thrombosis (blood clot formation)

Background: Among pediatric patients, newborns are at highest risk of thrombosis owing to differences in the neonatal hemostatic system (the system that helps bleeding to stop). Abnormal blood clot formation might start in an artery (blood going away from the heart) or in a vein (blood going toward the heart). Different management strategies have been described, ranging from "wait and see" to active management aimed at dissolving clots (fibrinolytic) and preventing clot formation (anticoagulant). Possible side effects of active management include secondary bleeding. However, in some cases, thrombosis can be a life‐threatening event requiring active management. Despite limited evidence on anticoagulant treatment in neonates, heparin has become a standard therapy. Current recommendations and dosing regimens for anticoagulative treatment are based on uncontrolled studies and have been adapted from data derived from reports on adult and pediatric patients. The evidence is current to May 2016.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2016

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