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High blood pressure in type 2 diabetes: Does lowering blood pressure to especially low levels have any advantages?

People with diabetes mellitus are at a greater risk of cardiovascular disease – especially if their blood pressure is too high. Lowering blood pressure to especially low levels can have both advantages and disadvantages for people with diabetes and high blood pressure. 

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: June 4, 2014

Drugs that aim to prevent the loss of protein or albumin through urine in people with sickle cell disease

We reviewed the evidence on the effect of drugs that aim to prevent loss of protein or albumin through urine in people with sickle cell disease.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2017

Gastrointestinal Complications (PDQ®): Patient Version

Expert-reviewed information summary about constipation, impaction, bowel obstruction, and diarrhea as complications of cancer or its treatment. The management of these problems is discussed.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: June 6, 2016

Interventions for non‐oliguric hyperkalaemia in preterm neonates

Elevated levels of potassium (an important salt for normal body functions) are common in infants born very preterm or with birth weight less than 1500 g. High potassium levels in the blood may lead to irregular or rapid heart rate that may result in bleedings in the brain and/or sudden death. The objective of this review was to determine the effectiveness and safety of interventions for this serious condition. Two studies enrolling 52 infants that assessed the use of a combination of insulin and sugar to reduce the blood levels of potassium were identified. This combination reduced the duration of high blood levels of potassium and the risk for bleeds in the brains of the infants. One study that enrolled 19 patients reported on the use of albuterol (a medication that helps to move potassium from the blood to the body cells). Albuterol lowered the blood levels of potassium both at four and at eight hours after the treatment had started. Because of the few infants enrolled in the studies to date, no firm recommendations for the treatment of too high blood levels of potassium in neonates can be made. Further research is needed.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Normal saline versus lower‐chloride solutions for kidney transplantation

People with kidney failure may have a kidney transplant to replace the function of their own kidneys. During a kidney transplant operation, patients receive fluids through their veins to keep them hydrated. Maintaining good hydration helps the transplanted kidney to work after the operation. The choice of fluids that are given during and after the operation may have an effect on how the transplant kidney works after surgery and on the patient's acid‐base measures in the blood.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2016

Milrinone to prevent reduced heart function and death after heart surgery in children

Background: Children who are born with heart defects often undergo heart surgery at a young age. They are at risk for reduced heart function and death after surgery. Milrinone is a medication that may be used in this situation to make the heart stronger and make it easier for the heart to pump blood into the body.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

Methods of milk expression for lactating women

The importance of human milk is well supported with the World Health Organization recommending that all infants should be fed exclusively on human milk from birth to six months of age and continued thereafter with appropriate complementary foods. Not all babies are able to feed at the breast and so expressed milk is needed.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2016

“ACE Inhibitors” and “ARBs” To Protect Your Heart? A Guide for Patients Being Treated for Stable Coronary Heart Disease

You have coronary heart disease, a disease affecting the arteries of your heart. You may have had a heart attack or suffer from chest pains with exercise, but your symptoms are not changing. Your coronary heart disease is in “stable” condition. This means that your symptoms have not changed or become worse. Your doctor recommends adding a medicine called an ACE Inhibitor or an ARB. You do not take medicine for high blood pressure (also called “hypertension”).

Comparative Effectiveness Review Summary Guides for Consumers [Internet] - Agency for Healthcare Research and Quality (US).

Version: July 9, 2010

Kidney stones: Overview

Kidney stones are very common, especially in people between the ages of 20 and 40. These small, hard deposits form in the renal pelvis and can enter a ureter. Larger stones can be painful and often have to be surgically removed. There are several options for treatment and prevention.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: February 25, 2016

Comparing single doses of oral analgesics for acute pain in adults after operation

Acute pain is often felt soon after injury. Most people who have surgery have moderate or severe pain afterwards. Painkillers (analgesics) are tested in people with pain, often following the removal of wisdom teeth. In all these studies the participants have to have at least moderate pain in order for there to be a sensitive measure of pain‐relieving properties. The pain is usually treated with painkillers taken by mouth. Results can be applied to other forms of acute pain.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of pancreatic neuroendocrine tumors (islet cell tumors).

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: July 30, 2015

Delirium (PDQ®): Patient Version

Expert-reviewed information summary about delirium as a complication of cancer or its treatment. Supportive care and pharmacologic approaches to the management of delirium are discussed.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: March 9, 2016

Adrenocortical Carcinoma Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of adrenocortical carcinoma.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: May 27, 2016

Late Effects of Treatment for Childhood Cancer (PDQ®): Patient Version

Expert-reviewed information summary about the health problems that continue or appear after cancer treatment has ended.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: August 11, 2016

Systematic Reviews in PubMed

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