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Is dexmedetomidine a good option for patients undergoing awake fibreoptic intubation?

This is a review of the clinical evidence from randomized controlled trials on the effect of dexmedetomidine in the management of awake fibreoptic intubation. The review was conducted by researchers in The Cochrane Collaboration. Awake fibreoptic intubation (AFOI) is indicated for the management of patients with a difficult or unstable (critical) airway, such as those with airway deformity or tumour, airway injury or spinal cord instability. It is necessary in such a situation to maintain patient co‐operation and reduce patient anxiety without causing severe adverse effects during the AFOI. Many agents, including fentanyl, remifentanil, midazolam and propofol, have been reported to assist with AFOI. However, these agents can cause respiratory arrest, loss of airway control or reduced cardiovascular (heart) function, especially when used in high doses, thus increasing the risk of low oxygen levels (hypoxaemia), aspiration, low blood pressure (hypotension) or slow heart rate (bradycardia).

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of pancreatic neuroendocrine tumors (islet cell tumors).

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: July 30, 2015

Gastrointestinal Complications (PDQ®): Patient Version

Expert-reviewed information summary about constipation, impaction, bowel obstruction, and diarrhea as complications of cancer or its treatment. The management of these problems is discussed.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: June 6, 2016

Adult Soft Tissue Sarcoma Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of adult soft tissue sarcoma.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: May 15, 2017

Melanoma Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of melanoma.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: June 16, 2017

Adult Central Nervous System Tumors Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of adult central nervous system tumors.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: August 26, 2016

Systematic Reviews in PubMed

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