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Linaclotide -- Benefit Assessment According to §35a Social Code Book V [Internet]

The aim of this report is to assess the added benefit of linaclotide compared with the appropriate comparator therapy (ACT) (medically advised dietary changes and symptom-orientated treatment [constipation, bloating, cramping, pain]) in patients with moderate to severe irritable bowel syndrome with constipation (IBS-C).

Institute for Quality and Efficiency in Health Care (IQWiG).

Version: July 30, 2013

Linaclotide: a new drug for the treatment of chronic constipation and irritable bowel syndrome with constipation

INTRODUCTION: Linaclotide is the first member of a novel class of drugs to be extensively evaluated for the treatment of chronic constipation (CC) and irritable bowel syndrome with constipation (IBS-C).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Effect of linaclotide in irritable bowel syndrome with constipation (IBS-C): a systematic review and meta-analysis

BACKGROUND: Treatment options for constipation-predominant irritable bowel syndrome (IBS-C) are limited. While linaclotide improved IBS-C symptoms in randomized controlled trials (RCTs), results vary among studies and the magnitude of benefit is unclear.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Effects of linaclotide in patients with irritable bowel syndrome with constipation or chronic constipation: a meta-analysis

BACKGROUND & AIMS: Linaclotide is a minimally absorbed, 14-amino acid peptide used to treat patients with irritable bowel syndrome with constipation (IBS-C) or chronic constipation (CC). We performed a meta-analysis to determine the efficacy of linaclotide, compared with placebo, for patients with IBS-C or CC.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Treatments for Constipation: A Review of Systematic Reviews [Internet]

Constipation has many definitions and is often described differently depending on the population queried. Physicians may define constipation as a reduction in the frequency of bowel movements to fewer than three times per week while patients identify more with the symptoms associated with constipation such as difficulty passing stool, hard stool consistency, feelings of abdominal cramping, and feelings of incomplete stool passage. Causes of constipation may be primary (idiopathic) or secondary to other factors such as diet, medication, or medical conditions. Constipation can affect anyone as a minor annoyance but up to a quarter of the population experiences it chronically or severely. It can substantially affect quality of life and be debilitating. It is estimated that between 2% to 27% of the population are affected depending upon the definition of constipation used.

Rapid Response Report: Summary with Critical Appraisal - Canadian Agency for Drugs and Technologies in Health.

Version: November 17, 2014
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Dicyclomine for Gastrointestinal Conditions: A Review of the Clinical Effectiveness, Safety, and Guidelines [Internet]

This Rapid Response report aims to review the clinical effectiveness and safety of dicyclomine for gastrointestinal (GI) conditions. Evidence-based guidelines associated with the use of dicyclomine in the management of GI conditions will also be examined.

Rapid Response Report: Summery With Critical Appraisal - Canadian Agency for Drugs and Technologies in Health.

Version: December 3, 2015
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Drug Class Review: Newer Diabetes Medications, TZDs, and Combinations: Final Original Report [Internet]

To compare the effectiveness and adverse event profiles of amylin agonists, DPP-4 inhibitors, incretin mimetics, TZDs, and certain combination products for people with type 2 diabetes and for people with type 1 diabetes for pramlintide only.

Drug Class Reviews - Oregon Health & Science University.

Version: February 2011
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Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis

The review found that laxatives, prucalopride, lubiprostone and linaclotide were all more effective than placebo for short-term treatment of chronic idiopathic constipation, but were associated with a greater frequency of diarrhoea. The authors' appropriate conclusions reflect the evidence base and are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Systematic Reviews in PubMed

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