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Efficacy and tolerability of frovatriptan in acute migraine treatment: systematic review of randomized controlled trials

This review assessed the efficacy and tolerability of frovatriptan for the treatment of acute migraine. The authors concluded that frovatriptan is more effective than placebo for the acute treatment of moderate to severe migraine, but it increases adverse effects. There were limitations in the reporting of the review methods but, overall, the authors' conclusions appear reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2005

Drug Class Review: Triptans: Final Report Update 4 [Internet]

Triptans, also called serotonin 5-hydroxytryptamine (5-HT)(1B/1D) agonists, are used to treat migraine and certain other headaches. Triptans act by binding to serotonin receptors in the brain, which leads to a reversal of blood vessel swelling. Triptans may be taken subcutaneously, orally as tablets, capsules, or quick-dissolving wafers, or intranasally as a spray. Currently, 7 triptans are available in the United States (almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan and zolmitriptan), as well as a fixed-dose combination product containing sumatriptan plus naproxen. Comparing the clinical efficacy and harms of the different triptans has been an area of considerable interest to researchers and patients, but is complex because of the large variety of outcome measures that can be measured in studies. The purpose of this review is to compare the efficacy, effectiveness, and harms of triptans.

Drug Class Reviews - Oregon Health & Science University.

Version: June 2009
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Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy: Final Report Update 2 [Internet]

Antiepileptic drugs have been used beyond treatment of seizure disorders since the 1960s. As new antiepileptic drugs have become available, there has been interest in how they compare with older therapies (carbamazepine, phenytoin, and valproate) and each other in disorders where conventional pharmacotherapy has typically been suboptimal and limited by drug-related toxicity. The objective of this report is to evaluate the comparative effectiveness and harms of antiepileptic drugs used for bipolar disorder, fibromyalgia, migraine prophylaxis, and chronic pain.

Drug Class Reviews - Oregon Health & Science University.

Version: October 2008
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Headaches: Diagnosis and Management of Headaches in Young People and Adults [Internet]

Many non-specialist healthcare professionals can find the diagnosis of headache difficult, and both people with headache and their healthcare professionals can be concerned about possible serious underlying causes. This leads to variability in care and may mean that people with headaches are not always offered the most appropriate treatments. People with headache alone are unlikely to have a serious underlying disease. Comparisons between people with headache referred to secondary care and those treated in primary care show that they do not differ in terms of headache impact or disability.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: September 2012
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Neuropathic Pain: The Pharmacological Management of Neuropathic Pain in Adults in Non-specialist Settings [Internet]

This short clinical guideline aims to improve the care of adults with neuropathic pain by making evidence-based recommendations on the pharmacological management of neuropathic pain outside of specialist pain management services. A further aim is to ensure that people who require specialist assessment and interventions are referred appropriately and in a timely fashion to a specialist pain management service and/or other condition-specific services.

NICE Clinical Guidelines - Centre for Clinical Practice at NICE (UK).

Version: November 2013
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Self-Harm: Longer-Term Management

This is the first NICE guideline on the longer-term management of both single and recurrent episodes of self-harm.

NICE Clinical Guidelines - National Collaborating Centre for Mental Health (UK).

Version: 2012
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Triptans in prevention of menstrual migraine: a systematic review with meta-analysis

The authors concluded that triptans were an effective short-term prophylactic treatment for menstrual migraines. Considering migraine frequency, severity and adverse events, frovatriptan 2.5mg twice daily and zolmitriptan 2.5mg three times daily were the most preferable regimens. The conclusion regarding the effectiveness of triptans seems reliable; the recommendations for further research were justified.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Acute treatment and prevention of menstrually related migraine headache: evidence-based review

This review found evidence to support the use of a number of medications in the acute treatment and short-term prevention of menstrually related migraine. Overall the review was well conducted, but the authors' specific recommendations for particular treatment regimes, especially where based on more limited evidence, should be treated with caution.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

Systematic Reviews in PubMed

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