Home > Search Results

Results: 1 to 20 of 38

[Systematic review of domperidone in clinical practice]

Bibliographic details: Wang Y, Chen S, Wu L.  [Systematic review of domperidone in clinical practice]. Chinese Journal of Gastroenterology 2011; 16(4): 226-230 Available from: http://dx.doi.org/10.3969/j.issn.1008-7125.2011.04.009

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

[Domperidone and the risk of sudden cardiac death].

Domperidone is an antiemetic drug with relatively few side-effects. In the Netherlands, domperidone is available over the counter. Recently, discussion on the safety of domperidone has arisen because an association with sudden cardiac death has been suggested. We performed a systematic literature search to investigate whether these concerns can be justified. Three out of four case-control studies found statistically significant increased odds ratios for sudden cardiac death when using domperidone. A dose-response relationship was described in one study. Results may be influenced by several confounders. We conclude that there is a relationship between domperidone use and sudden cardiac death at doses of more than 30 mg per day. We recommend that the indication be weighed up properly, that domperidone be provided only on prescription, and dose advice be given. At a dose of 30 mg per day, domperidone can be prescribed safely.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

[Proarrhythmic effects of domperidone in infants: a systematic review]

AIMS: To assess the association of the use of domperidone in infants with QTc interval prolongation and proarrhythmic events.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Medications for increasing milk supply in mothers expressing breastmilk for their hospitalised infants

Breastmilk remains the optimal form of enteral nutrition for term and preterm infants until up to six months postnatal age. Mothers of premature and sick infants are separated from their infants while they are receiving hospital‐based care. These mothers often have difficulty supporting lactation, when milk production is solely maintained by breast expression.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Acupuncture for treating functional dyspepsia

Functional dyspepsia (FD) has been a worldwide gastric disorder. More effective therapies are needed with fewer adverse effects than are seen with conventional medications. In the East, acupuncture has been recognized for a long time as a positive therapy for the treatment of functional gastric disorders. To date, no robust evidence on its efficacy and safety has been found. The evidence obtained has overwhelmingly supported no significance of acupuncture compared with medications and superiority of acupuncture compared with sham acupuncture in FD treatment; however, the low quality of evidence obtained has not permitted a robust conclusion concerning the efficacy and safety of acupuncture in the treatment of FD.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Medicines for children with gastro‐oesophageal reflux

Current medicines (e.g. Gaviscon Infant®) aim to thicken stomach contents, neutralise stomach acid (ranitidine, omeprazole, lansoprazole) or help the stomach to empty faster (domperidone). We looked at all available studies to try to find out whether any of the medicines currently used for reflux can help babies and children. We wanted to know whether these medicines make babies and children feel better, or whether test results (such as healing of the lining of the oesophagus, assessed through endoscopy (a small camera passed down the food pipe), or lowering of the amount of acidity in the oesophagus, assessed using a pH probe over 24 hours) get better when these medicines are given.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2016

Cannabis‐based medicine for nausea and vomiting in people treated with chemotherapy for cancer

As many as three‐quarters of people who receive chemotherapy experience nausea (feeling sick) and vomiting (being sick), which many find distressing. While conventional anti‐sickness medicines are effective, they do not work for everyone, all of the time. Therapeutic drugs based on the active ingredient of cannabis, known as THC (delta‐9‐tetrahydrocannabinol), have been approved for use as anti‐sickness medicines in some countries.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

Domperidone-associated sudden cardiac death in the general population and implications for use in patients undergoing hemodialysis: a literature review

BACKGROUND: Domperidone, an effective prokinetic agent, is commonly used to manage symptoms of gastroparesis. Health regulatory agencies have issued warnings about an increased risk of sudden cardiac death associated with use of this drug.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Effect of domperidone on insufficient lactation in puerperal women: a systematic review and meta-analysis of randomized controlled trials

The review concluded that, for some women experiencing insufficient breast milk production, evidence from a few small randomised trials of moderate-to-high quality suggested that domperidone produced a greater increase in milk supply than placebo. The conclusions from this well-conducted review are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Should domperidone be used for the treatment of gastro-oesophageal reflux in children: systematic review of randomized controlled trials in children aged 1 month to 11 years old

This review assessed the efficacy of domperidone for symptoms of gastro-oesophageal reflux and gastro-oesophageal reflux disease in children. The authors concluded that there is no strong evidence to support the use of domperidone. Despite limitations to the review, the authors' conclusion regarding the limitations of the evidence appear reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2005

A systematic review of the efficacy of domperidone for the treatment of diabetic gastroparesis

This review concluded that there was insufficient evidence to support the use of domperidone in gastroparesis and recommended further research. The conclusions were appropriately cautious, but search limitations reduced the likelihood of all relevant evidence being identified and made the included studies unlikely to be representative. It was not possible to determine the reliability of the conclusions.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

[Treatment of nausea and vomiting with prokinetics and neuroleptics in palliative care patients: a review]

BACKGROUND: Many recommendations concerning the treatment of nausea and vomiting in palliative care patients exist but what is the evidence for this? Most studies dealing with this topic have focused on cancer patients under chemotherapy and/or radiation therapy or on patients with postoperative nausea. Cancer patients without chemotherapy or radiation therapy, patients without postoperative nausea, and patients having other diseases with palliative care aspects, such as acquired immunodeficiency syndrome (AIDS), chronic obstructive pulmonary disease (COPD), progressive heart failure, amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) have been underrepresented in studies on nausea and vomiting so far.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia

This review, which assessed the effectiveness of prokinetic agents in patients with functional dyspepsia, concluded that prokinetic agents are effective as a short-term treatment. The review appears to have been conducted appropriately, but the reliability and generalisability of the results is potentially hindered by a number of limitations identified with the included studies.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: a systematic review and economic assessment

Study found evidence that some treatments (ginger, vitamin B6, antihistamines, metoclopramide) were better than placebo for mild symptoms of nausea and vomiting in pregnancy (NVP), but there is little on the effectiveness of treatments in more severe NVP/hyperemesis gravidarum.

Health Technology Assessment - NIHR Journals Library.

Version: October 2016
Show search results within this document

Proton Pump Inhibitors for Gastrointestinal Conditions: A Review of Clinical Effectiveness and Cost-Effectiveness [Internet]

The aim of the current review is to summarize current evidence on clinical and cost-effectiveness of proton pump inhibitors (PPIs) for the treatment of gastrointestinal diseases, which may be used to update knowledge mobilization tools developed based on earlier evidence.

Rapid Response Report: Summary with Critical Appraisal - Canadian Agency for Drugs and Technologies in Health.

Version: June 19, 2015
Show search results within this document

Care of Dying Adults in the Last Days of Life

This guideline applies to dying people aged 18 or older. It is acknowledged that a parallel guideline is being developed by NICE to cover the end of life care for infants, children and young people.

NICE Guideline - National Clinical Guideline Centre.

Version: December 16, 2015
Show search results within this document

Type 1 Diabetes in Adults: Diagnosis and Management

Type 1 diabetes affects over 370,000 adults in the UK, representing approximately 10% of adults diagnosed with diabetes. Given the complexity of its treatment regimens, successful outcomes depend, perhaps more than with any other long-term condition, on full engagement of the adult with type 1 diabetes in life-long day-by-day self-management. In order to support this, the health service needs to provide informed, expert support, education and training as well as a range of other more conventional biomedical services and interventionsfor the prevention and management of long term complications and disability.

NICE Guideline - National Clinical Guideline Centre (UK).

Version: August 2015
Show search results within this document

Gastro-Oesophageal Reflux Disease: Recognition, Diagnosis and Management in Children and Young People

This guideline focuses on symptoms of and interventions for gastro-oesophageal reflux disease (GORD). Commonly observed events, such as infant regurgitation, are covered, as well as much rarer but potentially more serious problems, such as apnoea. Where appropriate, clear recommendations are given as to when and how reassurance should be offered. In contrast, advice is given to health care professionals regarding when investigations should be considered or treatments are indicated. Finally, it is emphasised that other, and on occasion more serious, conditions that need different management can be confused with some of the relatively common manifestations of GOR or GORD. These warning signs are defined under the headings of ‘red flags’, along with recommended initial actions.

NICE Guideline - National Collaborating Centre for Women's and Children's Health (UK).

Version: January 2015
Show search results within this document

Dyspepsia and Gastro-Oesophageal Reflux Disease: Investigation and Management of Dyspepsia, Symptoms Suggestive of Gastro-Oesophageal Reflux Disease, or Both

The guideline applies to adults (aged 18 and over) with symptoms suggestive of dyspepsia, symptoms suggestive of gastro-oesophageal reflux disease (GORD), or both.

NICE Clinical Guidelines - Internal Clinical Guidelines Team (UK).

Version: September 2014
Show search results within this document

Parkinson's Disease: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care

It is almost 200 years since James Parkinson described the major symptoms of the disease that came to bear his name. Slowly but surely our understanding of the disease has improved and effective treatment has been developed, but Parkinson’s disease remains a huge challenge to those who suffer from it and to those involved in its management. In addition to the difficulties common to other disabling neurological conditions, the management of Parkinson’s disease must take into account the fact that the mainstay of pharmacological treatment, levodopa, can eventually produce dyskinesia and motor fluctuation. Furthermore, there are a number of agents besides levodopa that can help parkinsonian symptoms, and there is the enticing but unconfirmed prospect that other treatments might protect against worsening neurological disability. Thus, a considerable degree of judgement is required in tailoring individual therapy and in timing treatment initiation. It is hoped that this guideline on Parkinson’s disease will be of considerable help to those involved at all levels in these difficult management decisions. The guideline has been produced using standard NICE methodology and is therefore based on a thorough search for best evidence.

NICE Clinical Guidelines - National Collaborating Centre for Chronic Conditions (UK).

Version: 2006
Show search results within this document

Systematic Reviews in PubMed

See all (58)...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...