Home > Search Results

Results: 1 to 20 of 27

Collagenase Clostridium histolyticum -- Benefit Assessment According to §35a Social Code Book V [Internet]

The benefit assessment of the active substance collagenase was carried out for the approved therapeutic indication “Dupuytren’s contracture in adult patients with a palpable cord”.

Institute for Quality and Efficiency in Health Care (IQWiG).

Version: January 30, 2012

Hydrogel dressings for treating pressure ulcers

Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are areas of injury to the skin or the underlying tissue, or both. Pressure ulcers can be painful, may become infected, and affect quality of life. Those at risk of pressure ulcers include those with spinal cord injuries and people who are immobile or who have limited mobility such as some elderly people and people with acute or chronic conditions. In 2004 the total annual cost of treating pressure ulcers in the UK was estimated as being GBP 1.4 to 2.1 billion, which was equivalent to 4% of the total NHS expenditure. Pressure ulcers have been shown to increase length of hospital stay and the associated hospital costs. Figures from the USA suggest that 'pressure ulcer' was noted as a diagnosis for half a million hospital stays in 2006; for adults, the total hospital costs of these stays was USD 11 billion.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

Collagenase for intervertebral disk hernia: a systematic review

Bibliographic details: Meng Y, Wang L, Mao X, Zhou ZK, Li YP.  Collagenase for intervertebral disk hernia: a systematic review. Chinese Journal of Evidence-Based Medicine 2006; 6(12): 885-892

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Collagenase clostridium histolyticum for the treatment of Dupuytren’s contracture: systematic review and economic evaluation

This study could not identify any randomised controlled trials (RCTs) or high-quality comparative studies assessing collagenase versus surgical interventions for the treatment of patients with Dupuytren’s contracture (DC). Collagenase has demonstrated to be superior to placebo in short-term RCTs, with better results for metacarphophalangeal than proximal interphalangeal joints. It is unclear whether or not collagenase can be used as a second-line treatment for DC. Based on the current evidence, collagenase does not appear to be the most cost-effective option to treat moderate to severe DC in people considered to be suitable candidates for surgery. Other surgical treatments appear more cost-effective, with limited fasciectomy (a type of surgery) being the most cost-effective choice. However, there are uncertainties in the data used for the economic evaluation. There is a need for sound clinical studies to compare the effects and costs of collagenase injections with those of surgical treatments.

Health Technology Assessment - NIHR Journals Library.

Version: October 2015
Show search results within this document

Clinical efficacy and cost-effectiveness of Clostridium histolyticum collagenase injections in a subpopulation of Dupuytren's contracture patients

Bibliographic details: Syed AM, Mcfarlane J, Chester T, Powers D, Sibly F, Talbot-Smith A.  Clinical efficacy and cost-effectiveness of Clostridium histolyticum collagenase injections in a subpopulation of Dupuytren's contracture patients. European Orthopaedics and Traumatology 2014; 5(3): 311-316

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Effectiveness and safety of different injection sites of collagenase for lumbar intervertebral disc protrusion: a systematic review

Bibliographic details: Mao X, Wang L, Meng Y, Sun L, Li YP.  Effectiveness and safety of different injection sites of collagenase for lumbar intervertebral disc protrusion: a systematic review. Chinese Journal of Evidence-Based Medicine 2007; 7(1): 53-60

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

A meta-analysis of the effectiveness of ozone and collagenase treatments for herniated lumbar discs

Bibliographic details: Wang WX, Yang HF, Du Y, Xu XX, Li Y, Li B, Huang YY, Xiao YQ, Feng L.  A meta-analysis of the effectiveness of ozone and collagenase treatments for herniated lumbar discs. Journal of Interventional Radiology 2013; 22(1): 40-45 Available from: http://dx.doi.org/10.3969/j.issn.1008-794X.2013.01.009

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Needle or Open Fasciotomy for Dupuytren’s Contracture: A Review of the Comparative Efficacy, Safety, and Cost-Effectiveness – An Update [Internet]

Dupuytren’s contracture is a progressive condition in which connective cords form, thicken, and shorten (typically in the connective tissue of the palmar fascia), causing permanent flexion contractures of joints and of one or more fingers. The metacarpophalangeal joint (MCP) and the proximal interphalangeal joint (PIP) are most often affected. Eventually, the contractures lead to hand deformity and impaired hand function, and potentially reduced quality of life for the affected individual. Dupuytren’s contracture may present as an unilateral or bilateral disease. The primary cause of Dupuytren’s contracture has yet to be determined, although there is a strong hereditary component.

Rapid Response Report: Summary with Critical Appraisal - Canadian Agency for Drugs and Technologies in Health.

Version: November 11, 2013
Show search results within this document

Enzymatic wound debridement

This review concluded that collagenase ointment was more effective than placebo for debridement of leg ulcers, pressure ulcers and partial thickness burns. Evidence on other comparisons and impact on wound healing was limited or equivocal. The small size and uncertain quality of included studies and poor reporting of the review mean the reliability of these conclusions is unclear.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

Chemonucleolysis in lumbar disc herniation: a meta-analysis

This review concluded that chemonucleolysis with chymopapain was superior to placebo and as effective as collagenase, but heterogeneity between studies in the comparison with surgery made interpretation of the summary measure difficult. Given the small number of studies included, the potential for missed studies and the apparent publication bias, the conclusions of the review should be interpreted with some caution.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Debridement Procedures for Managing Diabetic Foot Ulcers: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines [Internet]

Debridement is the removal of necrotic tissue, foreign debris, bacterial growth, callus, wound edge, and wound bed tissue from chronic wounds in order to stimulate the wound healing process. Stimulation of wound healing mediated by debridement is thought to occur by the conversion of a chronic non-healing wound environment to an acute healing environment through the removal of cells that are not responsive to endogenous healing stimuli. Debridement is used commonly in standard wound treatment of diabetic foot ulcers (DFUs). Methods of debridement include surgery (sharp debridement), chemical debridement (antiseptics, polysaccharide beads, pastes), autolytic (hydrogels, hydrocolloids and transparent films), biosurgery (maggots), mechanical (hydrodebridement), and biochemical debridement (enzyme preparations). Callus is a buildup of keratinized skin formed under conditions of repeated pressure or friction and may contribute to ulcer formation by creating focal areas of high plantar pressure. The debridement of callus has been proposed to be relevant for both treatment and prevention of DFU.

Rapid Response Report: Summary with Critical Appraisal - Canadian Agency for Drugs and Technologies in Health.

Version: September 15, 2014
Show search results within this document

The Prevention and Management of Pressure Ulcers in Primary and Secondary Care

Prevention of pressure ulcers usually involves an assessment to identify people most at risk of pressure ulcers, such as elderly, immobile people or those with spinal cord injury. Assessments are most commonly carried out using specific pressure area risk scores (for example, the Braden or Waterlow scales for predicting pressure sore risk or the, Glamorgan scale for paediatric pressure ulcers).

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: April 2014
Show search results within this document

Surgical Site Infection: Prevention and Treatment of Surgical Site Infection

Infections that occur in the wound created by an invasive surgical procedure are generally referred to as surgical site infections (SSIs). SSIs are one of the most important causes of healthcare-associated infections (HCAIs). A prevalence survey undertaken in 2006 suggested that approximately 8% of patients in hospital in the UK have an HCAI. SSIs accounted for 14% of these infections and nearly 5% of patients who had undergone a surgical procedure were found to have developed an SSI. However, prevalence studies tend to underestimate SSI because many of these infections occur after the patient has been discharged from hospital.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: October 2008
Show search results within this document

Cost-effectiveness of non-invasive methods for assessment and monitoring of liver fibrosis and cirrhosis in patients with chronic liver disease: systematic review and economic evaluation

The study found that treating all patients with chronic hepatitis C without a prior non-invasive liver test (NILT) is cost-effective; however, recently approved interferon-free regimens were not included. For hepatitis B e antigen (HBeAg)-negative patients, this strategy is cost-effective only if the higher cost-effectiveness threshold is appropriate. For HBeAg-positive patients, two NILTs applied sequentially were cost-effective but highly uncertain. No conclusive results could be obtained for alcoholic and non-alcoholic fatty liver disease. Most studies evaluating non-invasive fibrosis tests had a high risk of bias.

Health Technology Assessment - NIHR Journals Library.

Version: January 2015
Show search results within this document

Different digestion enzymes used for human pancreatic islet isolation: a mixed treatment comparison (MTC) meta-analysis

Collagenases are critical reagents determining yield and quality of isolated human pancreatic islets and may affect islet transplantation outcome. Some islet transplantation centers have compared 2 or more collagenase blends; however, the results regarding differences in quantity and quality of islets are conflicting. Thus, for the first time, a mixed treatment comparison (MTC) meta-analysis was carried out to compile data about the effect of different collagenases used for human pancreas digestion on islet yield, purity, viability and stimulation index (SI). Pubmed, Embase and Cochrane libraries were searched. Of 755 articles retrieved, a total of 15 articles fulfilled the eligibility criteria and were included in the MTC meta-analysis. Our results revealed that Vitacyte and Liberase MTF were associated with a small increase in islet yield (islet equivalent number/g pancreas) when compared with Sevac enzyme [standardized mean difference (95% credible interval - CrI) = -2.19 (-4.25 to -0.21) and -2.28 (-4.49 to -0.23), respectively]. However, all other enzyme comparisons did not show any significant difference regarding islet yield. Purity and viability percentages were not significantly different among any of the analyzed digestion enzymes. Interestingly, Vitacyte and Serva NB1 were associated with increased SI when compared with Liberase MTF enzyme [unstandardized weighted mean difference (95% CrI) = -1.69 (-2.87 to -0.51) and -1.07 (-1.79 to -0.39), respectively]. In conclusion, our MTC meta-analysis suggests that the digestion enzymes currently being used for islet isolation works with similar efficiency regarding islet yield, purity and viability; however, Vitacyte and Serva NB1 enzymes seem to be associated with an improved SI as compared with Liberase MTF.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Interventions for the management of oral submucous fibrosis

Oral submucous fibrosis is a chronic disease which is commonly found in patients in the Asian subcontinent and the Far East and is characterised by the build up of constricting bands of collagen in the cheeks and adjacent structures of the mouth. The precise cause is unknown but chewing of betel quid as well as other areca nut containing products, excessive use of chillies and spices, poor nutrition and vitamin and iron deficiency have been suggested.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2008

Which dressings or topical agents are the most effective for healing pressure ulcers?

We reviewed the evidence about the effects of dressings and topical agents (such as ointments, creams and gels) on pressure ulcer healing. There are many different dressings and topical agents available, and we wanted to find out which were the most effective.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2017

Surgery for Dupuytren's disease of the fingers

We conducted a review of the effects of surgery for people with Dupuytren’s disease of the fingers and found 13 studies with 940 participants; 93 participants were reported twice in separate articles describing early and late outcomes of one trial.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

The Clinical Effectiveness and Cost-Effectiveness of Management Strategies for Sciatica: Systematic Review and Economic Model

Sciatica is a symptom characterised by well-localised leg pain with a sharp, shooting or burning quality that radiates down the back of the leg and normally to the foot or ankle. It is often associated with numbness or altered sensation in the leg.

Health Technology Assessment - NIHR Journals Library.

Version: November 2011
Show search results within this document

Anticoagulation Monitoring and Reversal Strategies for Dabigatran, Rivaroxaban, and Apixaban: A Review of Clinical Effectiveness [Internet]

The purpose of this report is to review the clinical effectiveness and cost of strategies to identify over-anticoagulation states and strategies to treat bleeding associated with the use of dabigatran, rivaroxaban, and apixaban, with the broader aim to help inform future listing recommendations and decisions, as well as clinical practice.

CADTH Therapeutic Review - Canadian Agency for Drugs and Technologies in Health.

Version: April 2012
Show search results within this document

Systematic Reviews in PubMed

See all (178)...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...