Home > Search Results

Results: 1 to 20 of 594

Testosterone and oestrogen steroid sex hormones for lower limb atherosclerosis

Atherosclerosis of the arteries of the legs can become symptomatic as people age. People affected may experience discomfort and cramping pain in the legs that is triggered by exercise and relieved with rest, termed intermittent claudication. Some people with claudication go on to require reconstructive surgery and even amputation of a leg. Risk factors for peripheral arterial disease include cigarette smoking, high blood pressure, high cholesterol, low levels of high density lipoprotein (HDL) cholesterol and blood flow problems. The steroid sex hormones oestrogens and testosterone affect a number of these risk factors, particularly cholesterol and blood clotting, and may be helpful in peripheral vascular disease.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

[Meta-analysis on influence of different doses of atorvastatin on carotid atherosclerosis in Chinese]

Bibliographic details: Liu SY, Zhang XJ, Cai H, Yang LY, Ding XN, Chang Y.  [Meta-analysis on influence of different doses of atorvastatin on carotid atherosclerosis in Chinese]. Journal of Jilin University (Medicine Edition) 2013; 39(2): 313-317 Available from: http://dx.doi.org/10.7694/jldxyxb20130227

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Angioplasty with stenting for intracranial atherosclerosis: a systematic review

OBJECTIVE: Intracranial artery stenosis can be fatal, requiring fast, safe and effective intervention. The introduction of the Wingspan™ stent system with Gateway™ percutaneous transluminal angioplasty balloon catheter has made intracranial intervention possible in a clinical trial setting. This systematic review planned to identify and review all randomized controlled trials comparing angioplasty and stenting of intracranial arteries with standard medical care.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Cryoplasty for peripheral vascular disease

The benefit of cryoplasty over conventional balloon angioplasty has yet to be definitely established as there are few randomised controlled trials evaluating this method. The technical success rates and rates of unobstructed arteries (primary patency) compared with conventional angioplasty seen in seven trials (478 patients) were inconsistent. Long‐term outcomes, in particular, are as yet to be assessed fully. Currently there are insufficient data to support the routine use of cryoplasty over conventional balloon angioplasty in the treatment of peripheral arterial disease.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Percutaneous transluminal rotational atherectomy for coronary artery disease

Atherosclerosis is the build‐up of fat and other substances within blood vessels. Several methods are used to remove this build‐up including a procedure known as percutaneous transluminalcoronary rotational atherectomy (PTCRA). PTCRA utilises small rotating devices to selectively remove the build‐up of atherosclerotic plaques from within coronary vessels. This review sought to determine whether PTCRA leads to improved patient outcomes compared to balloon angioplasty. It was important to do this review as it is not known whether or not PTCRA provides greater benefits to patients compared to balloon angioplasty.  The review analysed data from 12 studies, which showed that there is limited evidence to support the routine use of PTCRA for in‐stent re‐stenosis; however, only for those people who were not suitable for surgery. For those with complex lesions, PTCRA may provide some benefit in comparison to balloon angioplasty. The review also showed that patients receiving PTCRA were more likely to have perforations during the procedure compared to patients receiving balloon angioplasty. This review was limited by the small number of studies and deficiency of data reported in some of the studies. 

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Carotid endarterectomy for carotid stenosis in patients selected for coronary artery bypass graft surgery

People who have coronary artery disease requiring coronary artery bypass graft (CABG) surgery often have narrowing of other arteries. If the carotid artery, the artery carrying blood to the brain, is narrow (called carotid stenosis), this may increase the risk of stroke and other brain damage, complicating CABG surgery. Surgery to remove the carotid narrowing might prevent these complications of CABG surgery, but also has risks. We found no reliable evidence from randomised trials to indicate whether or not to perform preventive carotid surgery in patients who are going to have CABG surgery.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2009

Yoga for secondary prevention of coronary heart disease

Coronary heart disease (CHD) is a major cause of early cardiovascular‐related illness and death in most developed countries. Secondary prevention is a term used to describe interventions that aim to prevent repeat cardiac events and death in people with established CHD. Individuals with CHD are at the highest risk of coronary events and death. Lifestyle modifications play an important role in secondary prevention. Yoga has been regarded as both a type of physical activity and a stress management strategy. The physical and psychological benefits of yoga are well accepted, yet inappropriate practice of yoga may lead to musculoskeletal injuries, such as muscle soreness and strain. The aim of this systematic review was to determine the effectiveness of yoga for secondary prevention in CHD in terms of cardiac events, death, and health‐related quality of life. We found no randomised controlled trials which met the inclusion criteria for this review. Therefore, the effectiveness of yoga for secondary prevention in CHD remains uncertain. High‐quality randomised controlled trials are needed.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

Treatments for depression in patients with coronary artery disease

This review examined clinical trials on psychological treatments and antidepressant drugs in depressed patients with coronary artery disease. The objective was to determine the effects of these treatments on depression, death rates, cardiac events such as another heart attack or surgeries, healthcare costs and quality of life. Sixteen trials were identified as relevant for the review. Seven trials investigated psychological treatments, eight trials antidepressant medications and one trial comprised both psychological and drug treatments. Psychological treatments and antidepressant drugs proved to be slightly superior to usual care or placebo (inactive drug) with regard to depressive symptoms. Furthermore, antidepressant drugs might be superior to placebo in reducing subsequent hospitalization rates and emergency room visits. In contrast, there seems to be no positive effect on death rates and cardiac events. Results regarding quality of life are inconclusive. In summary, psychological treatments and antidepressant medications may have a small yet positive effect on depression outcomes in CAD patients. However, the evidence is sparse due to the low number of trials.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2011

Cardiac testing for coronary artery disease in potential kidney transplant recipients

Background: Patients with chronic kidney disease (CKD) are at increased risk of coronary artery disease (CAD) and adverse cardiac events. Screening for CAD is therefore an important part of preoperative evaluation for kidney transplant candidates. There is significant interest in the role of non‐invasive cardiac investigations and their ability to identify patients at high risk of CAD. 

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Prognostic value of endothelial function in patients with atherosclerosis: systematic review

Analysis of flow-mediated vasodilation (FMV) of the brachial artery by use of ultrasound allows assessing endothelial function, and provides pathophysiological, diagnostic and prognostic information. This systematic review was aimed at assessing the literature level of evidence of the predictive capacity of endothelial function, measured through brachial artery FMV by use of ultrasound, regarding cardiovascular events in individuals with atherosclerosis. The MEDLINE, SCIELO and LILACS databases were searched, and prospective cohort studies on human beings about the prognostic value of endothelial function, measured by use of brachial artery FMV in individuals with peripheral or coronary atherosclerosis, were selected. Studies with clear methodological biases were excluded. The final selection consisted of 15 studies. Of the 13 studies that on univariate analysis showed statistical significance of the FMV method to predict cardiovascular events, 12 showed independent predictive capacity on multivariate analysis. None of the studies reviewed described the incremental predictive value of FMV to the traditional predictive models, such as the Framingham score. Results of three studies have suggested that the method adds prognostic value to isolated markers such as ankle-brachial index (ABI), diabetes, and high-sensitivity C-reactive protein (hsCRP). In conclusion, brachial artery FMV predicts cardiovascular risk, but its incremental predictive value to clinical prognostic models has not been established. In addition, solid evidence supporting its use in routine clinical practice to predict cardiovascular risk still lacks.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Lack of association between TLR4 Asp299Gly polymorphism and atherosclerosis: evidence from meta-analysis

INTRODUCTION: Toll like receptor 4 (TLR4) expression was found to increase markedly in human atherosclerotic lesions, notably on macrophages and endothelial cells. TLR4 Asp299Gly polymorphism was associated with a blunted receptor activity and a subsequently diminished inflammatory response, and may subsequently reduce atherosclerosis (AS) risk. However, the results of molecular epidemiological studies remained inconsistent.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Chelation therapy for atherosclerotic cardiovascular disease

Not enough evidence about the effects of chelation therapy to reduce blockages in the blood vessels of people with atherosclerotic cardiovascular (heart and circulation) disease. Atherosclerosis is caused by fatty deposits sticking to the inside of people's arteries and restricting blood flow. People with blocked arteries are more likely to have strokes and heart attacks, and can often only walk short distances before their legs begin to ache. Chelation therapy involves infusions into the bloodstream of substances believed to remove metals from the blood. This is promoted to people with atherosclerotic heart and circulation disease as a way of breaking down the blockages in their blood vessels. However, the review found there is not enough evidence from trials about the effects of this treatment.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2008

Can suppression of inflammation by anti-TNF prevent progression of subclinical atherosclerosis in inflammatory arthritis?

OBJECTIVE: It remains a matter of debate whether TNF-a antagonists have favourable effects on the cardiovascular (CV) system. This systematic review evaluates the effect of TNF-a blockers on the progression of subclinical atherosclerosis and arterial stiffness in patients with inflammatory arthritis.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Atherosclerosis screening by noninvasive imaging for cardiovascular prevention: a systematic review

BACKGROUND: Noninvasive imaging of atherosclerosis is being increasingly used in clinical practice, with some experts recommending to screen all healthy adults for atherosclerosis and some jurisdictions mandating insurance coverage for atherosclerosis screening. Data on the impact of such screening have not been systematically synthesized.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Using steroids to treat Kawasaki disease

We reviewed the use of a set of drugs known as steroids in children affected by Kawasaki disease for the reduction in the chance of future heart problems as well as the effect on the duration of fever, signs of infection in the blood and the number of days spent in hospital.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2017

Perioperative statin use to improve outcomes during and after noncardiac vascular surgery

In July 2012 we searched medical databases for controlled trials of participants who had undergone aortic or arterial surgery and were randomly assigned to either statins or placebo (or standard care). Many vascular surgery patients are already taking statins; therefore we also included trials that randomly assigned participants to different doses of statin. Statin treatment should have been started any time between the decision to operate and performance of the operation and continued for at least 48 hours after the operation. We wanted to investigate the effect of this short‐term statin therapy on the risk of death and cardiovascular events such as heart attack and stroke within 30 days of surgery. We also considered adverse effects of statins such as muscle pain.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2013

Prognostic value of cystatin C in acute coronary syndromes: enhancer of atherosclerosis and promising therapeutic target

BACKGROUND: Cystatin C (CC) has been proposed to play a role in atherosclerosis. We aimed to review the prognostic value of CC serum/plasma levels in patients with acute coronary syndromes (ACS).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Internet‐based programmes for people with heart disease

Heart disease is the most common cause of ill health and preventable death. Cardiac rehabilitation is a programme that helps people with heart disease gain better health. It is held in group classes that take place at hospitals or within the community. People attend these classes once or twice a week for around six to eight weeks. The classes usually involve exercising, and receiving advice on ways to improve their health. People needing these programmes are not always able to attend them. An alternative is to provide this programme through the Internet. In this review we looked at whether programmes delivered through the Internet are helpful in improving death rates, the need for surgery, repeated heart attacks, cholesterol levels, blood pressure, health‐related quality of life (HRQOL), diet, physical activity, medication compliance, healthcare usage, and costs.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2016

Radiation-induced carotid artery atherosclerosis

PURPOSE: Carotid arteries frequently receive significant doses of radiation as collateral structures in the treatment of malignant diseases. Vascular injury following treatment may result in carotid artery stenosis (CAS) and increased risk of stroke and transient ischaemic attack (TIA). This systematic review examines the effect of radiotherapy (RT) on the carotid arteries, looking at the incidence of stroke in patients receiving neck radiotherapy. In addition, we consider possible surrogate endpoints such as CAS and carotid intima-medial thickness (CIMT) and summarise the evidence for radiation-induced carotid atherosclerosis.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Effects of statins on progression of carotid atherosclerosis as measured by carotid intimal-medial thickness: a meta-analysis of randomized controlled trials

BACKGROUND: Carotid intimal-medial thickness (CIMT) as measured by B-mode ultrasonography is a surrogate marker for carotid atherosclerosis. Studies have found conflicting results for the effect of statins on carotid atherosclerosis progression by measuring CIMT. Hence, this meta-analysis was conducted to evaluate the impact of statin therapy on CIMT progression.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Systematic Reviews in PubMed

See all (2387)...

Systematic Review Methods in PubMed

See all (22)...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...