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The drug axitinib (trade name: Inlyta) has been approved in Germany since September 2012 for patients with advanced renal cell cancer who have already had unsuccessful treatment with a cytokine or the drug sunitinib.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: July 27, 2017

The drug nivolumab (trade name: Opdivo) has been approved in Germany since April 2016 for the treatment of advanced renal cell cancer. The drug is an option for adults who have already had treatment.

Informed Health Online [Internet] - Institute for Quality and Efficiency in Health Care (IQWiG).

Version: August 1, 2016

Kidney cancer is rarely curable once it has spread to other organs at the time of diagnosis. Targeted agents are currently considered as the standard treatment for advanced kidney cancer that has spread to other organs. This review examines clinical studies that have directly compared immunotherapies or combination therapies to current standard therapy.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: May 15, 2017

Cancer of the kidney is an important health problem with over 15,000 deaths in North America annually. Kidney cancer in adults that has spread or is too advanced for surgery is incurable and is resistant to conventional chemotherapy drugs. Drugs that affect the body's immune system have been standard care in the past two decades but have been associated with unpleasant side effects and poor results in most patients. Recent advances in understanding the molecular biology of kidney cancer have resulted in the development of drugs that target known molecular pathways (targeted therapy). This review critically examines reports of clinical trials that have directly compared the new targeted "designer" drugs with previous standard therapies for this condition, to see if these drugs could be considered an advance in care.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Expert-reviewed information summary about the treatment of Gastrointestinal Stromal Tumors.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: July 28, 2015

Expert-reviewed information summary about the treatment of pheochromocytoma and paraganglioma.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: August 18, 2017

Expert-reviewed information summary about oral complications, such as mucositis and salivary gland dysfunction, that occur in cancer patients treated with chemotherapy or radiation therapy to the head and neck.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: December 16, 2016

Expert-reviewed information summary about the treatment of Wilms tumor.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: August 18, 2017

Expert-reviewed information summary about the treatment of childhood soft tissue sarcomas.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: August 18, 2017

Expert-reviewed information summary about the treatment of unusual cancers of childhood such as cancers of the head and neck, chest, abdomen, reproductive system, skin, and others.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: June 23, 2017

Systematic Reviews in PubMed

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Systematic Review Methods in PubMed

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