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Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis

This review examined the efficacy of vitamin K in treating excessive anticoagulation. The authors concluded that the limited evidence available suggests that oral or intravenous, but not subcutaneous, vitamin K are more effective than withholding anticoagulation therapy. The methods employed to combine the studies were inappropriate, thus it is impossible to determine whether these conclusions are reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Vitamin K to prevent fractures in older women: systematic review and economic evaluation

This review concluded that, while no recommendations could be made in practice on the use of vitamin K1 to prevent osteoporotic fractures in postmenopausal women, a large randomised controlled trial that compared vitamin K1 with alendronate (bisphosphonate) should be conducted. While there were some concerns over the review process methods, these conclusions appear likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials

This review investigated the effects of oral vitamin K supplements on bone mineral density and fractures. The authors concluded that supplementation may reduce bone loss and that an effect on fractures has been shown in Japanese patients. The cautious conclusions reflect the limitations of the available evidence and appear appropriate.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Recommendations for a Public Health Approach. 2nd edition

These guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, treatment and care.

World Health Organization.

Version: 2016
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Venous Thromboembolic Diseases: The Management of Venous Thromboembolic Diseases and the Role of Thrombophilia Testing [Internet]

Venous thromboembolism (VTE) is a condition in which a blood clot (a thrombus) forms in a vein and then dislodges to travel in the blood (an embolus). A venous thrombus most commonly occurs in the deep veins of the legs or pelvis; this is then called a deep vein thrombosis (DVT). Blood flow through the affected vein can be limited by the clot, and it can cause swelling and pain in the leg. If it dislodges and travels to the lungs, to the pulmonary arteries, it is called a pulmonary embolism (PE), which in some cases may be fatal. VTE as a term includes both DVT and PE. Major risk factors for VTE include a prior history of DVT, age over 60 years, surgery, obesity, prolonged travel, acute medical illness, cancer, immobility, thrombophilia (an abnormal tendency for the blood to clot) and pregnancy.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: June 2012
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Postnatal Care: Routine Postnatal Care of Women and Their Babies [Internet]

This guideline has been written within a conceptual framework which places the woman and her baby at the centre of care, appreciating that all postnatal care should be delivered in partnership with the woman and should be individualised to meet the needs of each mother-infant dyad. The guideline aims to identify the essential ‘core care’ which every woman and her baby should receive, as appropriate to their needs, during the first 6–8 weeks after birth, based upon the best evidence available.

NICE Clinical Guidelines - National Collaborating Centre for Primary Care (UK).

Version: July 2006
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Major Trauma: Assessment and Initial Management

This guideline provides guidance on the assessment and management of major trauma, including resuscitation following major blood loss associated with trauma. For the purposes of this guideline, major trauma is defined as an injury or a combination of injuries that are life-threatening and could be life changing because it may result in long-term disability. This guideline covers both the pre-hospital and immediate hospital care of major trauma patients but does not include any management after definitive lifesaving intervention. It has been developed for health practitioners and professionals, patients and carers and commissioners of health services.

NICE Guideline - National Clinical Guideline Centre (UK).

Version: February 2016
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Perioperative management of patients receiving oral anticoagulants: a systematic review

This review assessed the peri-operative management and outcomes of patients receiving long-term oral anticoagulant therapy. The authors concluded that for invasive and surgical procedures, oral anticoagulation needs to be withheld and further treatment decisions individualised. The review methodology was poorly reported and the authors' conclusions may be subject to a number of biases.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

Systematic Reviews in PubMed

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