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The objective of this review was to compare the clinical benefits and harms of guanfacine extended release (GXR; brand name: Intuniv XR) with those of other active treatments and placebo in children aged six to 12 years with attention-deficit/hyperactivity disorder (ADHD).

Common Drug Review - Canadian Agency for Drugs and Technologies in Health.

Version: July 2015

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) in adulthood is increasingly diagnosed and treated. Methylphenidate is frequently advocated as a first-line pharmacological treatment.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

This summary discusses the different types of treatment for ADHD. It explains what research says about how each treatment improves symptoms and the risks involved with each treatment. It can help you talk with the doctor about ADHD and your child.

Comparative Effectiveness Review Summary Guides for Consumers [Internet] - Agency for Healthcare Research and Quality (US).

Version: June 26, 2012

The objectives of this project are to:

CADTH Optimal Use Report - Canadian Agency for Drugs and Technologies in Health.

Version: August 2011

The objective of this report is to identify current utilization and expenditure on combinations and high doses of atypical antipsychotic agents for adolescents and adults with schizophrenia, in public and private drug plans in Canada.

CADTH Optimal Use Report - Canadian Agency for Drugs and Technologies in Health.

Version: August 2012

The study found that antipsychotics, noradrenergic agents and habit reversal training/comprehensive behavioural intervention for tics are effective in reducing tics in children and young people with Tourette syndrome. The balance of benefits and harms favours the most commonly used medications: risperidone (Risperdal®, Janssen), clonidine (Dixarit®, Boehringer Ingelheim) and aripiprazole (Abilify®, Otsuka).

Health Technology Assessment - NIHR Journals Library.

Version: January 2016

This guideline has been developed to advise on psychosocial interventions for drug misuse. The guideline recommendations have been developed by a multidisciplinary team of healthcare professionals, service users, a carer and guideline methodologists after careful consideration of the best available evidence. It is intended that the guideline will be useful to clinicians and service commissioners in providing and planning high-quality care for people who misuse drugs while also emphasising the importance of the experience of care for people who misuse drugs and their carers.

NICE Clinical Guidelines - National Collaborating Centre for Mental Health (UK).

Version: 2008

Antisocial behaviour and conduct disorders are the most common reason for referral to child and adolescent mental health services and have a significant impact on the quality of life of children and young people and their parents and carers. Rates of other mental health problems (including antisocial personality disorder) are considerably increased for adults who had a conduct disorder in childhood. This new NICE guideline seeks to address these problems by offering advice on prevention strategies, as well as a range of psychosocial interventions.

NICE Clinical Guidelines - National Collaborating Centre for Mental Health (UK).

Version: 2013

To compare the benefits and harms of second-generation antidepressants (SGAs), psychological, complementary and alternative medicine, and exercise treatment options as first-step interventions for adult outpatients with acute-phase major depressive disorder (MDD), and as second-step interventions for patients with MDD who did not achieve remission after a first treatment attempt with SGAs.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: December 2015

Expert-reviewed information summary about fatigue, a condition marked by extreme tiredness and inability to function because of lack of energy, often seen as a complication of cancer or its treatment.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: June 29, 2017

This review found that most long-acting stimulants conferred benefits in populations with attention-deficit/hyperactivity disorder for up to 12 hours as measured by mathematics tests. Methodological flaws and a lack of information about the quality of the studies mean that the results should be interpreted with some caution and made the reliability of the authors' conclusions unclear.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

The authors concluded that the greater efficacy found for stimulants compared with nonstimulants in children with attention-deficit/hyperactivity disorder (ADHD) needs to be interpreted with caution in view of the impact of potential confounding factors. There were limitations in the review process, but the authors’ conclusion appears appropriately cautious given the lack of head-to-head comparisons of different classes of ADHD drugs.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

This generally well-conducted review assessed the efficacy and safety of treatments for attention-deficit hyperactivity disorder in adults. The authors concluded that the use of immediate release methylphenidate as a first-line treatment was supported. The questionable quality of many of the included studies and some concerns over the appropriateness of the synthesis may mean these conclusions were overstated.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

The authors concluded that amphetamine products may be moderately more efficacious than methylphenidate products for children and adolescents with attention deficit hyperactivity disorder. Lack of direct comparison combined with inadequate reporting of review methods and limited validity assessment means that the authors’ conclusions should be interpreted with caution.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Systematic Reviews in PubMed

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