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At least one‐third of people with Parkinson's disease complain about fatigue. It is unclear what treatment is best to reduce fatigue in people with Parkinson's disease.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

A pharmacological agent with proven efficacy does not exist for treatment of cocaine misuse. Cocaine is an alkaloid derived from the erythroxylon coca leaf that is used as powder for intranasal or intravenous use or as crack, a free‐base form which is smoked. Cocaine misuse is a major public health problem because its use can be associated with medical and psychosocial complications including the spread of infectious diseases (such as AIDS, hepatitis and tuberculosis), crime, violence and neonatal drug exposure. In this Cochrane Review we looked at the evidence on the efficacy and acceptability of dopamine agonists as a treatment, used either alone or in combination with any psychosocial intervention, for people addicted to cocaine.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

It is almost 200 years since James Parkinson described the major symptoms of the disease that came to bear his name. Slowly but surely our understanding of the disease has improved and effective treatment has been developed, but Parkinson’s disease remains a huge challenge to those who suffer from it and to those involved in its management. In addition to the difficulties common to other disabling neurological conditions, the management of Parkinson’s disease must take into account the fact that the mainstay of pharmacological treatment, levodopa, can eventually produce dyskinesia and motor fluctuation. Furthermore, there are a number of agents besides levodopa that can help parkinsonian symptoms, and there is the enticing but unconfirmed prospect that other treatments might protect against worsening neurological disability. Thus, a considerable degree of judgement is required in tailoring individual therapy and in timing treatment initiation. It is hoped that this guideline on Parkinson’s disease will be of considerable help to those involved at all levels in these difficult management decisions. The guideline has been produced using standard NICE methodology and is therefore based on a thorough search for best evidence.

NICE Clinical Guidelines - National Collaborating Centre for Chronic Conditions (UK).

Version: 2006

This systematic review of interventions for antipsychotic-induced tardive dyskinesia found only underpowered trials of limited quality and recommended further well-designed pragmatic RCTs of currently used treatments.

Health Technology Assessment - NIHR Journals Library.

Version: August 2017

The objective of this report was to perform a systematic review of the beneficial and harmful effects of rotigotine for the treatment of the signs and symptoms of idiopathic Parkinson disease (PD).

Common Drug Review - Canadian Agency for Drugs and Technologies in Health.

Version: November 2016

This guideline covers the management of spasticity and co-existing motor disorders and their early musculoskeletal complications in children and young people (from birth up to their 19th birthday) with non-progressive brain disorders.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: July 2012

The core outcomes set in disease modification trials in mild to moderate dementia should include cognition markers for all trial participants and a structural magnetic resonance imaging scan for a subset.

Health Technology Assessment - NIHR Journals Library.

Version: May 2017

Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations in the legs and a distressing, irresistible urge to move them. RLS severity and burden vary widely, and the condition may require long-term treatment.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: November 2012

RATIONALE AND OBJECTIVES: The aim of this study was to perform a meta-analysis of published data about the diagnostic performance of (18)F-dihydroxyphenylalanine (DOPA) positron emission tomography (PET) or PET/computed tomography (CT) in detecting recurrent medullary thyroid carcinoma (MTC).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

This review evaluated medical and surgical treatments for Parkinson disease with levodopa-induced motor fluctuations and dyskinesia, and found the highest evidence was for the effectiveness of entacapone and rasagiline in reducing off time; treatment recommendations were reported. This is a well-conducted review and the authors' conclusions are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

This review assessed the effectiveness and safety of herbal medicines, alone or as a combined therapy, compared with placebo or conventional treatment of idiopathic Parkinson's disease. The authors' cautious conclusion, that current evidence is insufficient to evaluate either effectiveness or safety correctly, reflects the limited evidence from studies of poor methodological quality which do not provide robust evidence.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

The authors stated that short-term treatment with levodopa is effective and safe for restless legs syndrome, but evidence on long-term treatment is lacking. Given the wide variation in the primary studies, the poor reporting of methods and findings in the review, the use of unsuitable statistical methods and the questionable interpretation of safety data, these conclusions do not appear reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Systematic Reviews in PubMed

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