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Interstitial Cystitis (Painful Bladder Syndrome)

A chronic inflammatory condition of the bladder. In general, symptoms may include painful urination, pelvic pain, urinary urgency, and pressure in the bladder or pelvis.

PubMed Health Glossary
(Source: Wikipedia)

About Interstitial Cystitis (Painful Bladder Syndrome)

Interstitial cystitis (IC) is a condition that results in recurring discomfort or pain in the bladder and the surrounding pelvic region. The symptoms vary from case to case and even in the same individual. People may experience mild discomfort, pressure, tenderness, or intense pain in the bladder and pelvic area.

Symptoms may include an urgent need to urinate, a frequent need to urinate, or a combination of these symptoms. Pain may change in intensity as the bladder fills with urine or as it empties. Women's symptoms often get worse during menstruation. They may sometimes experience pain during vaginal intercourse.

Because IC varies so much in symptoms and severity, most researchers believe it is not one, but several diseases. In recent years, scientists have started to use the terms bladder pain syndrome (BPS) or painful bladder syndrome (PBS) to describe cases with painful urinary symptoms that may not meet the strictest definition of IC. The term IC/PBS includes all cases of urinary pain that can't be attributed to other causes, such as infection or urinary stones.

The term interstitial cystitis, or IC, is used alone when describing cases that meet all of the IC criteria established by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)....Read more about Interstitial Cystitis NIH - National Institute of Diabetes and Digestive and Kidney Diseases

What works? Research summarized

Evidence reviews

Intravesical treatments for painful bladder syndrome/interstitial cystitis(PBS/IC).

Interstitial cystitis is also known as painful bladder syndrome. It typically causes symptoms of bladder and pelvic pain, an increased urge to pass urine and excessive urination during both day and night. The cause of the condition is not well‐understood but it is thought to result from long‐standing inflammation of the bladder. Many treatments have been used for PBS/IC and in this review we assess the effects of putting medication directly into the bladder (bladder instillations) to treat it.

Intravesical resiniferatoxin for the treatment of storage lower urinary tract symptoms in patients with either interstitial cystitis or detrusor overactivity: a meta-analysis

BACKGROUND: While Resin-iferatoxin (RTX) has been widely used for patients with storage lower urinary tract symptoms (LUTS), its clinical efficiency hasn't yet been well evaluated. A meta-analysis was performed to evaluate the exact roles of intravesical RTX for the treatment of storage LUTS in patients with either interstitial cystitis (IC) or detrusor overactivity (DO).

Efficacy of sacral neuromodulation in treating chronic pain related to painful bladder syndrome/interstitial cystitis in adults

OBJECTIVE: The objective of this review is to evaluate the efficacy and safety of sacral neuromodulation in treating chronic pelvic pain related to Painful bladder syndrome/Interstitial-cystitis.

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Summaries for consumers

Intravesical treatments for painful bladder syndrome/interstitial cystitis(PBS/IC).

Interstitial cystitis is also known as painful bladder syndrome. It typically causes symptoms of bladder and pelvic pain, an increased urge to pass urine and excessive urination during both day and night. The cause of the condition is not well‐understood but it is thought to result from long‐standing inflammation of the bladder. Many treatments have been used for PBS/IC and in this review we assess the effects of putting medication directly into the bladder (bladder instillations) to treat it.

Cystitis: Overview

Cystitis is very common in women. It is caused by a bacterial infection. Typical symptoms include a burning pain during urination, often associated with having to go the bathroom more often. There are effective treatments for uncomplicated cystitis, and it usually clears up without any problems.

Urinary alkalisation for uncomplicated urinary tract infections

Urinary tract infection (UTI) is the most common form of bacterial infection among women and can cause pain and frequent urination.

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Terms to know

Bladder
The organ that stores urine.
Chronic
Refers to disorders that last a long time, often years. Chronic is the opposite of acute, or brief.
Cystoscopy
Examination of the bladder and urethra using a cystoscope, inserted into the urethra. A cystoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue.
Inflammation
Redness, swelling, pain, and/or a feeling of heat in an area of the body. This is a protective reaction to injury, disease, or irritation of the tissues.
Interstitial
An interstitial space or interstice is an empty space or gap between spaces full of structure or matter.
Pelvis
The bowl-shaped bone that supports the spine and holds up the digestive, urinary, and reproductive organs. The legs connect to the body at the pelvis.
Urinalysis
A test of a urine sample that can reveal many problems of the urinary tract and other body systems. The sample may be observed for color, cloudiness, concentration; signs of drug use; chemical composition, including glucose; the presence of protein, blood cells, or germs; or other signs of disease.

More about Interstitial Cystitis

Photo of an adult woman

Also called: Chronic interstitial cystitis, Bladder pain syndrome, IC, PBS, BPS, IC/PBS

Other terms to know: See all 7
Bladder, Chronic, Cystoscopy

Related articles:
How the Urinary System Works
Understanding Urine Tests

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