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Dupuytren Contracture

A condition in which the fingers and the palm of the hand thicken and shorten, causing the fingers to curve inward.

PubMed Health Glossary
(Source: NIH - National Institute of Diabetes and Digestive and Kidney Diseases)

About Dupuytren's Contracture

Dupuytren's contracture (also known as morbus Dupuytren or Dupuytren's disease) is a disorder of the hand that causes bundles of connective tissue fibers (fasciae) on the palm side of the hand to thicken and harden. This means that one or two fingers become permanently bent and can no longer be straightened. Institute for Quality and Efficiency in Heath Care

What works? Research summarized

Evidence reviews

Clinical efficacy and cost-effectiveness of Clostridium histolyticum collagenase injections in a subpopulation of Dupuytren's contracture patients

Bibliographic details: Syed AM, Mcfarlane J, Chester T, Powers D, Sibly F, Talbot-Smith A.  Clinical efficacy and cost-effectiveness of Clostridium histolyticum collagenase injections in a subpopulation of Dupuytren's contracture patients. European Orthopaedics and Traumatology 2014; 5(3): 311-316

Clinical effectiveness of post-operative splinting after surgical release of Dupuytren's contracture: a systematic review

The authors concluded that there was insufficient evidence from a small number of low quality studies to determine the effectiveness of splints following Dupuytren’s contracture surgery and that further research was required. The authors’ conclusions appeared to reflect the limited evidence presented and were likely to be reliable.

Needle or Open Fasciotomy for Dupuytren’s Contracture: A Review of the Comparative Efficacy, Safety, and Cost-Effectiveness – An Update [Internet]

Dupuytren’s contracture is a progressive condition in which connective cords form, thicken, and shorten (typically in the connective tissue of the palmar fascia), causing permanent flexion contractures of joints and of one or more fingers. The metacarpophalangeal joint (MCP) and the proximal interphalangeal joint (PIP) are most often affected. Eventually, the contractures lead to hand deformity and impaired hand function, and potentially reduced quality of life for the affected individual. Dupuytren’s contracture may present as an unilateral or bilateral disease. The primary cause of Dupuytren’s contracture has yet to be determined, although there is a strong hereditary component.

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Summaries for consumers

Collagenase extracted from Clostridium histolyticum (Xiapex) for Dupuytren’s contracture: Overview

Collagenase extracted from Clostridium histolyticum (trade name Xiapex in Germany, or Xiaflex in the U.S.) has been approved in Germany since 2011 for the treatment of Dupuytren’s contracture.

More about Dupuytren Contracture

Photo of an adult

Also called: Dupuytren's contracture, Morbus Dupuytren

Other terms to know:
Fascia, Fasciotomy

Keep up with systematic reviews on Dupuytren Contracture:

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