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Dysphoria is a profound state of unease or dissatisfaction. Dysphoria may accompany depression, anxiety, or agitation. It can also mean someone that is not comfortable in their current body, particularly in cases of gender dysphoria.

PubMed Health Glossary
(Source: Wikipedia)

What works? Research summarized

Evidence reviews

[Treatment of premenstrual dysphoria with antidepressants: review of controlled clinical trials]

Bibliographic details: Cheniaux E.  [Treatment of premenstrual dysphoria with antidepressants: review of controlled clinical trials]. [Tratamento da disforia pre-menstrual com antidepressivos: revisao dos ensaios clinicos controlados .] Jornal Brasileiro de Psiquiatria 2006; 55(2): 142-147

Long-acting Reversible Contraception: The Effective and Appropriate Use of Long-Acting Reversible Contraception

Contraception can be divided into two broad categories: hormonal and nonhormonal. There are two categories of hormonal contraception: combined oestrogen and progestogen and progestogen-only. Long-acting reversible contraception (LARC) is defined in this guideline as methods that require administering less than once per cycle or month.

Preventing Alzheimer's Disease and Cognitive Decline

To assess whether previous research on purported risk or protective factors for Alzheimer’s disease (AD) and cognitive decline is of sufficient strength to warrant specific recommendations for behavioral, lifestyle, or pharmaceutical interventions/modifications targeted to these endpoints.

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Summaries for consumers

Central action beta‐blockers versus placebo for neuroleptic‐induced acute akathisia

Akathisia is recognised as one of the most common and distressing of the early‐onset adverse effects of neuroleptic drugs. This movement disorder is characterised by a subjective report of inner restlessness, mental unease or dysphoria, which can be intense.

Cannabis‐based medicine for nausea and vomiting in people treated with chemotherapy for cancer

As many as three‐quarters of people who receive chemotherapy experience nausea (feeling sick) and vomiting (being sick), which many find distressing. While conventional anti‐sickness medicines are effective, they do not work for everyone, all of the time. Therapeutic drugs based on the active ingredient of cannabis, known as THC (delta‐9‐tetrahydrocannabinol), have been approved for use as anti‐sickness medicines in some countries.

Antidepressants for people with both schizophrenia and depression

Depression is common in people with schizophrenia and is associated with substantial problems including an increased risk of suicide. Many clinicians use antidepressant drugs in addition to anti‐psychotics in order to treat depression. This review identified eleven randomised controlled trials that compared antidepressants with a placebo in people with schizophrenia who also had depression. There was some evidence that antidepressants did lead to an improvement in global outcome, but the small number of studies providing usable data and their poor quality, suggest that this evidence should be interpreted with caution. At present, there is no convincing evidence either to support or refute the use of antidepressants in treating depression in people with schizophrenia. Further well‐designed, conducted and reported research is needed in this area.

More about Dysphoria

Photo of an adult

Also called: Dysphoric

See Also: Euphoria, Premenstrual Dysphoric Disorder

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