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Oral Herpes (Cold Sore)

A type of herpes simplex. An outbreak typically causes small blisters or sores on or around the mouth. The sores typically heal within 2-3 weeks, but the herpes virus remains, periodically reactivating (in symptomatic people) to create sores in the same area of the mouth or face.

PubMed Health Glossary
(Source: Wikipedia)

What works? Research summarized

Evidence reviews

Oral antivirals for preventing recurrent herpes simplex keratitis in people with corneal grafts

Cochrane researchers aimed to find out if treatment with an antiviral medication at the time of the corneal graft, for example acyclovir, lowers the chance of herpes simplex virus (HSV) returning and causing inflammation (keratitis). They were also interested in whether this lowered the chance of the graft failing. They collected and analysed all relevant studies to answer this question and found three studies.

(Oral antiviral treatment to prevent genital herpes outbreaks in immunocompetent and nonpregnant patients)

Are oral antiviral drugs (acyclovir, famciclovir, and valacyclovir) effective compared with placebo? And is one of these three drugs superior to the others in suppressing genital herpes outbreaks in patients experiencing four or more recurrences per year? Effectiveness in this review was evaluated by determining the risk of experiencing at least one recurrence during the treatment period in each group.

Treatment for the first time men and women get genital herpes (first‐episode genital herpes)

The aim of this research was to look at the positive and adverse effects of treatments, on the duration of symptoms, in people who have their first episode of genital herpes.

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Summaries for consumers

Oral antivirals for preventing recurrent herpes simplex keratitis in people with corneal grafts

Cochrane researchers aimed to find out if treatment with an antiviral medication at the time of the corneal graft, for example acyclovir, lowers the chance of herpes simplex virus (HSV) returning and causing inflammation (keratitis). They were also interested in whether this lowered the chance of the graft failing. They collected and analysed all relevant studies to answer this question and found three studies.

(Oral antiviral treatment to prevent genital herpes outbreaks in immunocompetent and nonpregnant patients)

Are oral antiviral drugs (acyclovir, famciclovir, and valacyclovir) effective compared with placebo? And is one of these three drugs superior to the others in suppressing genital herpes outbreaks in patients experiencing four or more recurrences per year? Effectiveness in this review was evaluated by determining the risk of experiencing at least one recurrence during the treatment period in each group.

Treatment for the first time men and women get genital herpes (first‐episode genital herpes)

The aim of this research was to look at the positive and adverse effects of treatments, on the duration of symptoms, in people who have their first episode of genital herpes.

See all (23)

More about Oral Herpes

Photo of a young adult

Also called: Herpes labialis, Herpes simplex labialis, Fever blister, Orolabial herpes, Human herpesvirus 1, Herpes simplex virus 1, HHV 1, HSV 1

Other terms to know:
Antivirals, Herpes Simplex Viruses, Viruses

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